Article
Medicine, General & Internal
Chiara Lubrano, Emanuela Taricco, Chiara Coco, Fiorenza Di Domenico, Chiara Mando, Irene Cetin
Summary: Alterations in intrauterine fetal growth increase the risk of adverse perinatal and neonatal outcomes. Risk factors for fetal growth alterations include advanced age, being primiparous, and a lower pregestational BMI. Prematurity, hyperlactacidemia, and hypoxemia are the main factors contributing to worse neonatal outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Christian Giommi, Marta Lombo, Nina Montik, Michela Paolucci, Valentina Notarstefano, Giovanni Delli Carpini, Andrea Ciavattini, Antonio Ragusa, Francesca Maradonna, Elisabetta Giorgini, Oliana Carnevali
Summary: Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are metabolic-related diseases that can occur during pregnancy. This study investigated the changes in the placental chorionic villi (CVs) of GDM and SGA patients. The results showed higher levels of SOD-1 and CAT in GDM placentae, which may be related to the hyperglycemic environment. Lipid composition and structure of the placenta were altered in both pathologies, with SGA inducing lipid peroxidation and reducing collagen deposition in the CVs. The cannabinoid system does not seem to be involved in these two pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Yihuang Huang, Lan Zhang, Huiqing Sun, Cuiqing Liu, Yi Yang, Shoo K. Lee, Yun Cao, Siyuan Jiang
Summary: The study showed that SGA infants admitted to Chinese NICUs had higher rates of death or major morbidity, mortality, bronchopulmonary dysplasia, necrotizing enterocolitis, and sepsis compared to non-SGA infants. The risk of adverse outcomes was independently associated with SGA status and was highest among infants with a birthweight <3rd percentile, across different gestational age groups. Specific attention is needed when caring for SGA preterm infants to improve outcomes.
TRANSLATIONAL PEDIATRICS
(2021)
Review
Infectious Diseases
Tormod Rebnord, Rolv Terje Lie, Anne Kjersti Daltveit, Ingvild Fossgard Sandoy
Summary: This study found that protease inhibitor (PI)-based combination antiretroviral treatment (cART) and cART initiation before conception may be associated with a slightly increased risk of small-for-gestational-age (SGA) infants. The evidence supporting these findings was of low certainty.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Acoustics
Danilo Buca, Giuseppe Rizzo, Sarah Gustapane, Ilenia Mappa, Martina Leombroni, Francesca Bascietto, Maria Elena Flacco, Cecilia Acuti Martellucci, Lamberto Manzoli, Luigi Nappi, Alessandra Familiari, Giovanni Scambia, Marco Liberati, Francesco D'Antonio
Summary: The study found that Doppler ultrasound parameters were not associated with adverse pregnancy outcomes in appropriate for gestational age (AGA) fetuses at term. The diagnostic performance of Doppler parameters for predicting adverse intrapartum outcomes and abnormal acid-base status at birth was poor.
ULTRASCHALL IN DER MEDIZIN
(2021)
Article
Acoustics
C. Briffa, C. Di Fabrizio, E. Kalafat, V. Giorgione, R. Bhate, C. Huddy, J. Richards, S. Shetty, A. Khalil
Summary: This study aimed to compare the impact of using twin-specific and singleton growth charts on the diagnosis of small-for-gestational age (SGA) and its association with adverse neonatal outcomes. The results showed that infants classified as SGA using twin-specific charts had a significantly higher risk of adverse neonatal outcomes compared to those classified using singleton charts.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kelly K. Ferguson, Sara Sammallahti, Emma Rosen, Michiel van den Dries, Anjoeka Pronk, Suzanne Spaan, Monica Guxens, Henning Tiemeier, Romy Gaillard, Vincent W. V. Jaddoe
Summary: This study identified three distinct fetal growth trajectories for weight among babies born small for gestational age (SGA). Children who were consistently small from mid-pregnancy had the worst neurodevelopmental outcomes at age 6, showing lower IQ and slightly more ADHD symptoms compared to non-SGA babies. The findings suggest that fetal growth trajectories may help identify SGA babies who are at risk for poor neurodevelopmental outcomes.
Article
Pediatrics
Dan Wu, Jianzheng Zhu, Xiulian Wang, Huiqing Shi, Yanyan Huo, Meiyan Liu, Fanfan Sun, Hongyan Lan, Chong Guo, Honghua Liu, Tingting Li, Lian Jiang, Xiangying Hu, Tianshu Li, Jing Xu, Guoying Yao, Guowei Zhu, Guangjun Yu, Jinjin Chen
Summary: This study found that rapid increase in BMI during early infancy in former SGA newborns leads to a persistent risk of obesity, highlighting the importance of controlling energy intake and closely monitoring BMI changes for optimal management.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pediatrics
Wayne Cutfield, Ahila Ayyavoo
Summary: 'Small for Gestational Age' (SGA) refers to children born with low birth weight and/or short birth length, most of whom experience catch-up growth within 6 months of age. Treatment with recombinant human growth hormone (rhGH) can help SGA children achieve normal adult height, although they may still face long-term consequences such as insulin resistance, abdominal fat accumulation, and metabolic disorders.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Nutrition & Dietetics
Shangzhi Xu, Weiming Wang, Qian Li, Li Huang, Xi Chen, Xu Zhang, Xiaoyi Wang, Weizhen Han, Xingwen Hu, Xuefeng Yang, Liping Hao, Guoping Xiong, Nianhong Yang
Summary: This study found that higher Hb concentrations in late pregnancy and less reduction in Hb during pregnancy were associated with an increased risk of SGA in women at low risk of iron deficiency.
Article
Public, Environmental & Occupational Health
Korede K. Yusuf, Deepa Dongarwar, Dania E. Alagili, Sitratullah O. Maiyegun, Hamisu M. Salihu
Summary: This study examined the temporal trends and risk of small for gestational age (SGA) phenotypes among Asian American ethnic groups using population-based retrospective data. The findings showed that NH-Whites had the lowest SGA rates, while all Asian ethnic groups had consistently higher rates. Among the Asian subgroups, Asian Indians had the highest odds of any SGA compared to NH-Whites. The study highlights the importance of recognizing the diversity within the Asian American population for effective health research and interventions.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Allen J. Wilcox, Marianna Cortese, D. Robert McConnaughey, Dag Moster, Olga Basso
Summary: The study found that birthweight percentiles performed poorly in identifying high-risk infants, while gestational age was effective. The results in Norway and the United States were virtually identical, suggesting this trend is robust across populations.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Obstetrics & Gynecology
Chaelin Lee, Seung Mi Lee, Dong Jun Byun, So Yeon Kim, Hugh Kim, Do Yup Lee, Young Mi Jung, Chan-Wook Park, Joong Shin Park, Man Ho Choi
Summary: Increased levels of tetrahydrocortisol and decreased levels of 21-deoxycortisol were observed in pregnant women carrying small-for-gestational-age (SGA) fetuses. The combination of 21-deoxycortisol concentration and two metabolic ratios of cortisol/21-deoxycortisol and tetrahydrocortisol/cortisol can serve as potential biomarkers for predicting SGA in the first trimester.
REPRODUCTIVE SCIENCES
(2022)
Article
Developmental Biology
Junshen He, Zhao Chen, Ting Wen, Liqun Xu, Chunlin Chen, Ping Liu
Summary: This study suggests that IVIM analysis can serve as an important supplement to ultrasound biometry for the noninvasive identification of false positive SGA pregnancies and SGA patients.
Article
Acoustics
S. Ruiz-Martinez, J. L. Delgado, C. Paules, A. Cavallaro, C. De Paco, J. Villar, A. Papageorghiou, D. Oros
Summary: This study identified nine clinical phenotypes of small-for-gestational-age (SGA) fetuses that are associated with different patterns of adverse perinatal outcomes. The findings suggest that considering clinical characteristics in addition to ultrasound findings could improve risk stratification and decision-making for managing SGA fetuses.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Psychiatry
Inbal Shlomi Polachek, Mordechai Dulitzky, Lilia Margolis-Dorfman, Michal J. Simchen
ARCHIVES OF WOMENS MENTAL HEALTH
(2016)
Article
Obstetrics & Gynecology
Michal Dviri, Michal J. Simchen, Anat Kalter, Shali Mazaki Tovi, Orit Moran, Eyal Schiff, Eyal Sivan, Israel Hendler
JOURNAL OF PERINATAL MEDICINE
(2015)
Article
Developmental Biology
Y. Yinon, E. Ben Meir, L. Margolis, S. Lipitz, E. Schiff, S. Mazaki-Tovi, M. J. Simchen
Article
Medicine, Research & Experimental
Alina Weissmann-Brenner, Michal J. Simchen, Eran Zilberberg, Anat Kalter, Mordechai Dulitzky
MEDICAL SCIENCE MONITOR
(2015)
Article
Obstetrics & Gynecology
Michal J. Simchen, Avital L. Okrent Smolar, Mordechai Dulitzky, Eyal Sivan, Iris Morag
JOURNAL OF PERINATAL MEDICINE
(2016)
Article
Obstetrics & Gynecology
Keren Ofir, Liat Lerner-Geva, Valentina Boyko, Eran Zilberberg, Eyal Schiff, Michal J. Simchen
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2013)
Article
Obstetrics & Gynecology
Iris Morag, Avital L. Okrent, Tzipora Strauss, Orna Staretz-Chacham, Jacob Kuint, Michal J. Simchen, Amir Kugelman
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2015)
Article
Obstetrics & Gynecology
Keren Ofir, Anat Kalter, Orit Moran, Eyal Sivan, Eyal Schiff, Michal J. Simchen
JOURNAL OF PERINATAL MEDICINE
(2013)
Article
Obstetrics & Gynecology
Hagit Shani, Rafael Kuperstein, Alla Berlin, Michael Arad, Ilan Goldenberg, Michal J. Simchen
JOURNAL OF PERINATAL MEDICINE
(2015)
Article
Rheumatology
Y. Berkun, M. J. Simchen, T. Strauss, S. Menashcu, S. Padeh, G. Kenet
Meeting Abstract
Obstetrics & Gynecology
Keren Ofir, Liat Lerner-Geva, Valentina Boyko, Eran Zilberberg, Eyal Schiff, Michal J. Simchen
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2014)
Article
Oncology
Ayala Maayan-Metzger, Aaron Lubetsky, Jacob Kuint, Nurit Rosenberg, Michal J. Simchen, Amir Kuperman, Tzipora Strauss, Ben-Ami Sela, Gili Kenet
PEDIATRIC BLOOD & CANCER
(2013)
Article
Medicine, General & Internal
Itai Gat, Mordechai Dulitzki, Eyal Schiff, Eyal Sivan, Michal J. Simchen
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2014)
Article
Psychology, Developmental
Iris Morag, Orit Bart, Raanan Raz, Shira Shayevitz, Michal J. Simchen, Tzipora Strauss, Samuel Zangen, Jacob Kuint, Lidia Gabis
INFANT BEHAVIOR & DEVELOPMENT
(2013)