期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 26, 期 9, 页码 908-914出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2013.766686
关键词
Adiponectin; fetal programming; food restriction; leptin; obesity
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education Science and Technology [2011-0004200, 2010-0026225]
- Global Top 5 Project
- National Research Foundation of Korea [2010-0007910, 2010-0026225] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Objective: We investigated the effects of fetal undernutrition during pregnancy/lactation on visceral fat, lipid profiles, leptin and adiponectin, and examined the gender differences between males and females. Study design: From 10 d to term gestation and through lactation, control pregnant rats were fed ad libitum (AdLib) food, whereas study rats were 50% food restricted (FR). Cross-fostering techniques were used to examine the effects of FR during pregnancy and lactation periods. Lipid profiles, leptin and adiponectin were determined in offspring at ages 3 weeks and 6 months. We also measured the amount of visceral fat in the offspring. Results: The amount of visceral fat in the 6-month-old FR/AdLib offspring was higher than that in the control (p < 0.05). Among the 6-month-old offspring, triglyceride and leptin levels were higher in FR/AdLib offspring than those in the controls (p < 0.05). The female offspring had higher levels of triglyceride, HDL-cholesterol, and adiponectin and the male offspring had higher levels of LDL cholesterol and leptin. Conclusion: Fetal undernutrition only during pregnancy resulted in obese offspring, higher levels of plasma triglyceride and leptin with gender differences.
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