期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 27, 期 2, 页码 149-154出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2013.806896
关键词
HbA(1c); glucose spikes; predictors; pregnancy outcome
资金
- Novo Nordisk
- Novo Nordisk Fonden [NNF14OC0009275] Funding Source: researchfish
Objective: To analyse data from a randomised, controlled study of prandial insulin aspart versus human insulin, both with NPH insulin, in pregnant women with type 1 diabetes for potential factors predicting poor pregnancy outcomes. Research design/method: Post hoc analysis including 91 subjects randomised prior to pregnancy with known outcome in early pregnancy and 259 subjects randomised prior to pregnancy/during pregnancy of <10 weeks' gestation with known late-pregnancy outcomes. Poor early-pregnancy outcomes included fetal loss <22 gestational weeks and/or congenital malformation n = 18). Poor late-pregnancy outcomes included: composite endpoint including pre-eclampsia, preterm delivery and perinatal death n = 78); preterm delivery n = 63); and excessive fetal growth n = 88). Results: 18 patients experienced a malformed/lost fetus in early pregnancy - none preceded by severe hypoglycaemia. Albuminuria in early pregnancy was a significant predictor of poor late-pregnancy outcome composite endpoint; p = 0.012). In the third trimester, elevated HbA(1c), >= 1 plasma glucose PG) measurement <11 mmol/L 198 mg/dL) and %PG values outside 3.9-7.0 mmol/L 70-126 mg/dL) were significant predictors of poor late-pregnancy outcomes all p < 0.05). Conclusions: Elevated HbA(1c), high glucose spikes and out-of-range % PG in the third trimester, and albuminuria in early pregnancy, are associated with poor late-pregnancy outcomes.
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