Article
Medicine, General & Internal
Sandra E. Juul, Thomas R. Wood, Bryan A. Comstock, Krystle Perez, Semsa Gogcu, Mihai Puia-Dumitrescu, Sara Berkelhamer, Patrick J. Heagerty
Summary: Understanding the causes and circumstances of death in extremely preterm infants is crucial for healthcare practitioners. This study retrospectively examined a cohort of infants born between 24 and 27 weeks of gestation to determine the risk factors, causes, timing, and circumstances of death. The study found that respiratory distress or failure, pulmonary hemorrhage, necrotizing enterocolitis, catastrophic intracranial hemorrhage, sepsis, and sudden unexplained death were the primary causes of death. The risk of death decreased over time, and preterm labor was associated with a decreased hazard of death. Clinical factors such as low birth weight, low Apgar score, sick appearance at birth, necrotizing enterocolitis, pulmonary hemorrhage, severe intracranial hemorrhage, and severe sepsis were also associated with death.
Article
Medicine, General & Internal
Frank H. Bloomfield, Yannan Jiang, Jane E. Harding, Caroline A. Crowther, Barbara E. Cormack
Summary: This study found that giving extra parenteral amino acids at a dose of 1 g per day for 5 days after birth did not increase the number of infants with extremely low birth weight who survived without neurodisability at 2 years.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Biology
Hudson P. Santos Jr, Adam E. Enggasser, Jeliyah Clark, Kyle Roell, Vasyl Zhabotynsky, William Adam Gower, Diana Yanni, Nou Gao Yang, Lisa Washburn, Semsa Gogcu, Carmen J. Marsit, Karl Kuban, T. Michael O'Shea, Rebecca C. Fry
Summary: Health outcomes for premature children differ between sexes, with males being more affected, but the underlying mechanism is unclear. CpG methylation levels in the placenta and blood also differ by sex and are associated with adverse health outcomes. By analyzing the methylation patterns in the placenta and neonatal blood samples from the ELGAN cohort, we found tissue-specific differences in methylation patterns between males and females, providing new insights into the epigenetic mechanisms underlying sexually dimorphic health outcomes among extremely premature infants.
Review
Pediatrics
Olivier Baud, Matthew Laughon, Philippe Lehert
Summary: This study aimed to provide a new predictive model for early prediction of survival without bronchopulmonary dysplasia in extremely preterm infants. By adding candidate variables at birth associated with BPD in previous studies, the modified model showed significantly better discrimination and better confirmed calibration than the existing NICHD Neonatal Research Network BPD estimator.
Article
Endocrinology & Metabolism
Thang Dao, Dale Lee Robinson, Lex W. Doyle, Peter V. S. Lee, Joy Olsen, Ashwini Kale, Jeanie L. Y. Cheong, John D. Wark
Summary: This study investigated the bone structure and estimated bone strength of young adults born extremely preterm or extremely low birth weight. The results showed that the EP/ELBW survivors had lower bone parameters compared to the controls, especially among males. These findings suggest a higher long-term fracture risk in EP/ELBW survivors.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Medicine, General & Internal
Ting-ting Lin, Chen Zhang, Lei Chen, Li Jin, Xian-hua Lin, Jie-xue Pan, Cindy-Lee Dennis, Ben W. Mol, He-feng Huang, Yan-ting Wu
Summary: A study in Shanghai found that non-infected pregnant women in their second trimester during COVID-19 lockdown had an increased risk of preterm birth. Additionally, pregnant women in their third trimester during the lockdown had a higher risk of premature rupture of membranes-induced preterm birth compared to those in the non-lockdown period.
FRONTIERS IN MEDICINE
(2021)
Article
Pediatrics
Zhiwen Su, Weiliang Huang, Qiong Meng, Chunhong Jia, Bijun Shi, Xi Fan, Qiliang Cui, Jingsi Chen, Fan Wu
Summary: This study used propensity score matching (PSM) analysis to evaluate the impact of hypertensive disorders of pregnancy (HDP) on the clinical outcomes of extremely preterm or extremely low birth weight (EP/ELBW) infants. The results showed that HDP increased the risk of periventricular leukomalacia (PVL) in these infants.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Xiaohong Ji, Chengqian Wu, Min Chen, Lili Wu, Ting Li, Zhijing Miao, Yan Lv, Hongjuan Ding
Summary: This study aimed to identify risk factors and analyze birth conditions and complications of premature births. The results showed that premature rupture of membranes (PROM) was the most common risk factor for extremely preterm and very preterm births, while cervical insufficiency, multiple pregnancy, and primipara were independent risk factors for extremely preterm birth. The study also found that the incidence of neonatal complications varied with gestational weeks, with earlier gestational weeks associated with higher rates of complications.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Heiddis Valgeirsdottir, Inger Sundstrom Poromaa, Theodora Kunovac Kallak, Eszter Vanky, Tansim Akhter, Nathalie Roos, Olof Stephansson, Anna-Karin Wikstrom
Summary: Women with PCOS have a higher risk of extremely preterm birth, particularly with spontaneous onset, compared to women without PCOS. This information is important for antenatal risk assessment and further research on the biological mechanisms behind preterm birth in women with PCOS is needed.
Article
Immunology
Chunhua Yin, Jingrui Chen, Xuena Wu, Yeling Liu, Quan He, Ying Cao, Yi-E Huang, Sisun Liu
Summary: This study suggests that patients who deliver preterm demonstrate altered gut microbiome that may contain higher common oral bacteria. Opportunistic pathogens, particularly Porphyromonas, Streptococcus, Fusobacterium, and Veillonella, were enriched in preterm patients, while Coprococcus and Gemmiger were markedly depleted. These potential oral-to-gut bacteria were correlated with clinical parameters reflecting maternal and fetal status.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pediatrics
Christina L. Herrera, Priyanka S. Kadari, Jessica E. Pruszynski, Imran Mir
Summary: Maternal infection does not appear to be directly linked to neurodevelopmental impairment or death at 2 years of age in extremely preterm infants. However, acute histologic chorioamnionitis is associated with this outcome, suggesting the need for further research into the impact of infection and immune response on outcomes in extremely preterm infants.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Wen Zhong, Hanna Danielsson, Abdellah Tebani, Max J. Karlsson, Anders Elfvin, Gunnel Hellgren, Nele Brusselaers, Petter Brodin, Ann Hellstrom, Linn Fagerberg, Mathias Uhlen
Summary: The study found that preterm infants have a unified protein profile in blood at birth, but this pattern changes dramatically within a week and up to term-equivalent age, showing more diverse protein profiles. Certain clusters of proteins were identified depending on their temporal trend.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Debra E. Weese-Mayer, Juliann M. Di Fiore, Douglas E. Lake, Anna Maria Hibbs, Nelson Claure, Jiaxing Qiu, Namasivayam Ambalavanan, Eduardo Bancalari, James S. Kemp, Amanda M. Zimmet, John L. Carroll, Richard J. Martin, Katy N. Krahn, Aaron Hamvas, Sarah J. Ratcliffe, Narayanan Krishnamurthi, Premananda Indic, Alaleh Dormishian, Phyllis A. Dennery, J. Randall Moorman
Summary: The study found that cardioventilatory events peak during the first month of life in extremely preterm infants, but the trajectory afterwards depends on the type of event, race, sex, and use of mechanical ventilation. Apnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. Apnea and intermittent hypoxemia were inversely correlated with gestational age, while periodic breathing was positively correlated with gestational age.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, General & Internal
Guillermo Gallagher-Cobos, Teresa Almerich-Torres, Jose Maria Montiel-Company, Jose Enrique Iranzo-Cortes, Carlos Bellot-Arcis, Jose Carmelo Ortola-Siscar, Jose Manuel Almerich-Silla
Summary: The aim of this study was to investigate the association between the mother's periodontal condition and perinatal complications, such as preterm birth and low birth weight. The results showed no statistically significant relationship between maternal periodontal disease and preterm birth or low birth weight, but tobacco use during pregnancy was associated with low birth weight.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jayne Trickett, Marialivia Bernardi, Amanda Fahy, Rebecca Lancaster, Jennifer Larsen, Yanyan Ni, Emmi Suonpera, Dieter Wolke, Neil Marlow, Samantha Johnson
Summary: Children born extremely preterm are at increased risk of sleep disturbances compared to term-born children, with night wakings partially mediating the relationship between preterm birth and ADHD symptoms and emotional problems.
Review
Immunology
Cesare de Gregorio, Luigi Colarusso, Giuseppe Calcaterra, Pier Paolo Bassareo, Antonio Ieni, Anna Teresa Mazzeo, Giuseppe Ferrazzo, Alberto Noto, Ioanna Koniari, Jawahar L. Mehta, Nicholas G. Kounis
Summary: In this literature review, rare side effects related to cerebral venous sinus thrombosis (CVST) after COVID-19 vaccination were investigated. The majority of cases occurred in women who received the AZD1222/Vaxzevria vaccine, with thrombi primarily located in transverse, sigmoid, and superior sagittal sinuses. Brain injury, mainly intracranial bleeding, was observed in a significant number of patients.
Review
Sport Sciences
Giuseppe Calcaterra, Vassilios Fanos, Luigi Cataldi, Lucia Cugusi, Antonio Crisafulli, Pier Paolo Bassareo
Summary: During the COVID-19 pandemic, there was a decline in sports activities among children and adolescents, but now with the easing of restrictions, sports activities are being resumed. Parents should consult the child's physician before allowing them to resume physical exercise and a careful physical examination should be performed.
SPORT SCIENCES FOR HEALTH
(2022)
Review
Pediatrics
Pier Paolo Bassareo, Stephen T. O'Brien, Esme Dunne, Sophie Duignan, Eliana Martino, Francesco Martino, Colin J. Mcmahon
Summary: This article discusses the forms of coronary disease in childhood, the predisposing factors of atherosclerosis, and the strategies that can be employed in childhood to detect and reduce the development of atherosclerosis in later life.
Article
Cardiac & Cardiovascular Systems
Pier Paolo Bassareo, Kevin Patrick Walsh
Summary: This study retrospectively evaluated the insertion of Micra leadless permanent pacemakers in ACHD patients. The results showed that Micra PPM can be successfully implanted in ACHD patients and have significant theoretical advantages. They should be considered as an alternative approach when transvenous and epicardial pacing are contraindicated.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Pier Paolo Bassareo, Klevis Mihali, Kevin Patrick Walsh
Summary: This article reports a unique adverse event in an adult patient with congenital heart disease after receiving the adenoviral COVID-19 vaccine.
CLINICAL CASE REPORTS
(2022)
Meeting Abstract
Hematology
Fabiola Guerra, Serena Gasperini, Sonia Bonanomi, Viola Crescitelli, Liviana Da Dalt, Giuseppe D. Norata, Marta Balzarini, Andrea Biondi, Andrea Baragetti, Francesco Saettini
Letter
Peripheral Vascular Disease
Giuseppe Calcaterra, Pier Paolo Bassareo, Francesco Barilla, Javahar L. Mehta
Article
Pediatrics
Pier Paolo Bassareo, Paola Argiento, Colin Joseph McMahon, Esme Dunne, Kevin Patrick Walsh, Maria Giovanna Russo, Michele D'Alto
Summary: Paediatric pulmonary hypertension (PH) is a complex illness with high morbidity and mortality if left untreated. Limited long-term data are available for the subtype idiopathic pulmonary arterial hypertension (IPAH) in children. This study evaluated the clinical features and outcomes of 10 paediatric patients with IPAH over a 20-year period. The results indicate the need for lung transplantation and significant mortality in this population.
Review
Pediatrics
Pier Paolo Bassareo, Massimo Chessa, Giovanni Di Salvo, Kevin Patrick Walsh, Colin Joseph Mcmahon
Summary: Patients with congenital heart disease (CHD) require lifelong surveillance, but loss of follow-up is a common problem, leading to worsening health and increased morbidity and mortality. A systematic review found a worldwide average loss of follow-up of 26.1%, with significant variation by continent and country. The highest discontinuity was seen in the USA and in patients with simple CHD. Strategies to minimize loss of follow-up include planning transition rules, involving general practitioners, and fostering good relationships between pediatric and adult CHD teams.
Review
Health Care Sciences & Services
Mario Panebianco, Marco Alfonso Perrone, Maria Giulia Gagliardi, Lorenzo Galletti, Pier Paolo Bassareo
Summary: While pregnancy can be managed in most patients with congenital heart disease, those with pulmonary arterial hypertension are advised against it. Even patients with univentricular hearts converted to Fontan circulation can still have manageable pregnancies. Personalized risk stratification is important, especially for patients in advanced NYHA functional class. Metabolomics may be a new tool for personalized risk stratification. Tertiary care centers capable of providing necessary assistance should manage all pregnancies, especially high-risk ones. Vaginal delivery is generally preferred over caesarean section to minimize complications. Motherhood can often be achieved for women with congenital heart disease, bringing hope to their lives.
Editorial Material
Cardiac & Cardiovascular Systems
Michele D'Alto, Pier Paolo Bassareo
Review
Medicine, General & Internal
Sara Moscatelli, Isabella Leo, Francesco Bianco, Nunzia Borrelli, Matteo Beltrami, Manuel Garofalo, Elena Giulia Milano, Giandomenico Bisaccia, Ferdinando Iellamo, Pier Paolo Bassareo, Akshyaya Pradhan, Andrea Cimini, Marco Alfonso Perrone
Summary: Cardiomyopathies are the leading cause of heart transplantation in children. Diagnosing and classifying these diseases can be challenging, especially in pediatric patients. Cardiovascular imaging, particularly echocardiography, plays a crucial role in the diagnostic pathway. However, complementary imaging modalities such as cardiovascular magnetic resonance may be necessary for differentiating between similar phenotypes. Nuclear imaging and computed tomography also have advantages but are less commonly used in pediatric patients due to radiation concerns.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Pier Paolo Bassareo, Michele D'Alto
Summary: Pulmonary hypertension (PH) is a complex disease that can lead to irreversible pulmonary arterial hypertension (PAH) and death. Metabolomics is a laboratory technique that can provide insights into the metabolic pathways related to PH/PAH. This systematic review identified specific metabolic fingerprints and highlighted the potential for new therapeutic agents targeting the disarranged metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pediatrics
Alessandra Piras, Giada Melis, Lucia Cugusi, Pier Paolo Bassareo
Summary: m-RNA vaccines have been authorized for use in adults, children, and adolescents aged 12-18. However, there have been increasing reports of myocarditis and/or pericarditis primarily in males after the second vaccine shot. This analysis confirms that most cases are mild and responsive to medical treatment, and reveals that older people, especially females, can also be affected by this adverse event.
Letter
Health Care Sciences & Services
Cesare de Gregorio, Giuseppe Calcaterra, Nicholas G. Kounis, Pier Paolo Bassareo, Jawahar L. Mehta
LANCET REGIONAL HEALTH-EUROPE
(2022)
