期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 24, 期 6, 页码 822-826出版社
INFORMA HEALTHCARE
DOI: 10.3109/14767058.2010.531315
关键词
L-Arginine; fetal growth restriction; Bcl-2; Bax
资金
- Research Foundation of Henan Provincial Health Authority [200697]
Objective. To investigate the effect of L-arginine on fetal growth restriction (FGR) in terms of expression of Bcl-2 and Bax in placenta. Methods. Sixty pregnant women with FGR were randomized to receive conventional treatment alone (control group, n = 30) or in combination with L-arginine (L-arginine group, n = 30). The parameters of fetal growth and development were monitored by B-ultrasound at regular intervals. The newborn birth weight and perinatal outcomes were also documented. Placental tissue was sampled within 10 min after delivery for analysis. The expression of Bcl-2 and Bax in placental tissue was determined by immunohistochemical technique. Results. The fetal growth parameters of biparietal diameter, femur length, and abdominal circumference increased more significantly in L-arginine group than those in control group (p < 0.0l). The cure rate and birth weight in L-arginine group were higher than those in control group (73.3%% vs. 43.3%%, 2455.20 g vs. 2402.63 g, respectively). The incidence of small for gestational age newborns in L-arginine group was significantly lower than that in control group. Compared with L-arginine group, the Bax expression increased, but bcl-2 expression decreased in control group. Conclusions. L-arginine could reduce the expression of Bax, and enhance the expression of bcl-2, which may be associated with reduced placental apoptosis and improved placental function and fetal development.
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