Article
Immunology
Erica L. Plummer, Lenka A. Vodstrcil, Kaveesha Bodiyabadu, Gerald L. Murray, Michelle Doyle, Rosie L. Latimer, Christopher K. Fairley, Matthew Payne, Eric P. F. Chow, Suzanne M. Garland, Catriona S. Bradshaw
Summary: The study found that only Mycoplasma hominis was associated with symptoms/signs in nonpregnant women, specifically related to bacterial vaginosis. Ureaplasma species were not associated with symptoms/signs. Therefore, routine testing for Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum in nonpregnant women is not supported.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ian Boostrom, Yohan Bala, Jelena Minic Vasic, Jelena Gluvakov, Emmanuel Chanard, Andrew H. Barratt, Kirsty Sands, Edward Portal, Laurence Devigne, Lucy C. Jones, Owen B. Spiller
Summary: The study evaluated the accuracy, sensitivity and specificity of MYCOPLASMA IST3, showing promising results in detecting urogenital mycoplasma infections.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Can Wang, Jingshuang Wang, Juan Yan, Feng Chen, Ying Zhang, Xuelian Hu
Summary: This article reports four cases of peritoneal dialysis (PD)-associated peritonitis caused by Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum, along with a literature review. The four cases were female patients with recurrent culture-negative PD-associated peritonitis, which was related to menstruation. These pathogens were detected in the PD fluid of the patients using metagenomic next-generation sequencing. All four patients were cured by intraperitoneal tigecycline combined with oral azithromycin or minocycline. Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum should be given more attention in female patients with recurrent culture-negative PD-associated peritonitis, especially when it is related to menstruation, sexual intercourse, or urogenital tract operation. Moreover, metagenomic next-generation sequencing can provide a reasonable method to identify the pathogen for culture-negative PD-associated peritonitis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Su Zhang, Ke Xu, Su-Xiao Liu, Xiao-Lan Ye, Ping Huang, Hong-Juan Jiang
Summary: This study investigated the prevalence of azithromycin-resistant U. urealyticum and M. hominis infections in pregnant women and explored the possible influencing factors and consequences of insensitive Mycoplasma infection. It was found that azithromycin-resistant cervical Mycoplasma infection in pregnant women was associated with a significantly increased incidence of adverse pregnancy outcomes.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biology
Wei-wei Zheng, Wen-jing Zhang, Di Cui, Zheng-chao Nie, Bang-sheng Ding, Jiang-hua Cheng, Chuan-zhong Mei
Summary: The study revealed a high infection rate of Ureaplasma urealyticum and Mycoplasma hominis in the genitourinary tract of Chinese patients, primarily affecting individuals aged 21-40 years, with variations in antibiotic sensitivity.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Jingjing Luo, Xinan Wu, Xue Gang, Nana Zhang, Feifei Wang, Chengting Rong
Summary: This article reports a rare case of artificial joint infection caused by Mycoplasma hominis and Ureaplasma urealyticum. The patient recovered well after appropriate treatment, with no evidence of infection recurrence during the follow-up period.
Article
Immunology
Amin Dehghan, Mohammad Reza Pourmand, Vahid Salimi, Firouzeh Akbari Asbagh, Abbas Rahimi Foroushani, Kaveh Sadeghi, Samaneh Hosseini Quchani
Summary: This study investigated the impact of CT, MH, and UU infections on semen quality and found that these infections significantly affect the quality and properties of male reproductive health.
MICROBIAL PATHOGENESIS
(2022)
Article
Medical Laboratory Technology
Ruixiang Luo, Kang Xun, Lingli Zuo, Feifei Sha, Yun Chen, Nong Yu, Donghua Jin, Yuxian Xie, Meiling He, Fang Liu
Summary: This study investigated the infection and antimicrobial resistance of Ureaplasma urealyticum and Mycoplasma hominis in patients with genital tract diseases in Jiangsu, China. The results showed a high prevalence of U. urealyticum mono-infections and an increasing overall infection rate in the past 3 years. Females had a higher infection rate than males, and the main age group affected was 20-39. The antimicrobial resistance rates varied for different drugs, with lower resistance observed for gatifloxacin, josamycin, minocycline, and doxycycline, and higher resistance observed for azithromycin, clindamycin, roxithromycin, sparfloxacin, and ofloxacin. The antimicrobial resistance of U. urealyticum and M. hominis to these drugs has been changing in the past 3 years.
CLINICAL LABORATORY
(2022)
Article
Medical Laboratory Technology
Ruixiang Luo, Kang Xun, Lingli Zuo, Feifei Sha, Yun Chen, Nong Yu, Donghua Jin, Yuxian Xie, Meiling He, Fang Liu
Summary: This study aimed to investigate the infection and antimicrobial resistance of Ureaplasma urealyticum and Mycoplasma hominis in patients with genital tract diseases in Jiangsu, China. The results showed an increasing infection rate over the past 3 years, with higher rates in females and the 20-39 age group. U. urealyticum and M. hominis displayed relatively lower resistance rates to certain antibiotics, but higher resistance rates to others.
CLINICAL LABORATORY
(2021)
Article
Obstetrics & Gynecology
Yasuhiro Miyoshi, Sachie Suga, So Sugimi, Nao Kurata, Hiroshi Yamashita, Ichiro Yasuhi
Summary: Vaginal colonization of Ureaplasma urealyticum/Mycoplasma hominis may predict preterm delivery in patients with threatened preterm birth or asymptomatic short cervix.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Enty Tjoa, Shikha Joon, Lucky H. Moehario
Summary: The study aimed to compare diagnostic parameters of the AF Genital System (R) with culture methods and PCR for identifying M. hominis and U. urealyticum in Indonesian women. The AF Genital System (R) showed lower sensitivity but reasonable specificity compared to PCR and culture methods.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Obstetrics & Gynecology
Gkp Cunha, L. B. Bastos, S. F. Freitas, R. C. Cavalli, S. M. Quintana
Summary: The study concluded that genital mycoplasma infection is not a risk factor for spontaneous preterm birth, even when combined with other abnormal vaginal microbiota. The presence of bacterial vaginosis did not increase the risk of preterm birth in pregnant women with mycoplasma infection.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Pediatrics
Tong Sun, Jianhua Fu
Summary: In the intrauterine Ureaplasma urealyticum (UU) infection group, premature infants had significantly prolonged duration of oxygen use and ventilator use in the hospital, with higher levels of leukocytes, platelets, and procalcitonin compared to the non-UU infection group. The incidence of bronchopulmonary dysplasia, retinopathy of prematurity, and metabolic bone disease in premature infants in the UU infection group was significantly higher.
FRONTIERS IN PEDIATRICS
(2021)
Article
Medical Laboratory Technology
Lu-Qing Zheng, Qing-Yong Wang
Summary: We retrospectively reviewed reports of 4,166 female outpatients detected by the mycoplasma identification verification and antibiotic susceptibility kit from the last five years. Among them, more than 73.3% of cases with Ureaplasma urealyticum or Mycoplasma hominis single infection or co-infection with both species were susceptible to three tetracyclines and one macrolide (josamycin). Additionally, more than 84.8%, less than 4.4%, and less than 39.6% of the U. urealyticum, M. hominis, and co-infection cases, respectively, were susceptible to clarithromycin and roxithromycin. Four quinolones (ciprofloxacin, ofloxacin, sparfloxacin, and levofloxacin) and three macrolides (azithromycin, erythromycin, and acetylspiramycin) were active against less than 48.9% of the isolates. Furthermore, 77.8%, 18.4%, and 7.5% of the M. hominis, U. urealyticum, and co-infection cases, respectively, were susceptible to spectinomycin.
CLINICAL LABORATORY
(2023)
Article
Pediatrics
Francesca Gallini, Domenico Umberto De Rose, Maria Coppola, Maria Sofia Pelosi, Francesco Cota, Anthea Bottoni, Daniela Ricci, Domenico Marco Romeo, Teresa Spanu, Luca Maggio, Eugenio Mercuri, Giovanni Vento
Summary: This study aimed to evaluate the neurodevelopmental outcomes of preterm infants born to mothers with Ureaplasma/Mycoplasma colonization during pregnancy. The study found that infants exposed to colonization had poorer locomotor abilities compared to unexposed infants, while the incidences of cognitive and motor impairments were similar between the two groups.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)