Article
Immunology
Eduardo Villamor, Mikael Norman, Stefan Johansson, Sven Cnattingius
Summary: This study found that maternal overweight and obesity severity are associated with an increased risk of EOS, especially in term infants. Half of the impact is mediated through preeclampsia, cesarean section delivery, and preterm delivery. A dose-response association was consistently present in term infants.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Sadiya S. Khan, Lucia C. Petito, Xiaoning Huang, Katharine Harrington, Rebecca B. McNeil, Natalie A. Bello, C. Noel Bairey Merz, Eliza C. Miller, Rupa Ravi, Christina Scifres, Janet M. Catov, Victoria L. Pemberton, Jasmina Varagic, Phyllis C. Zee, Lynn M. Yee, Mitali Ray, Jin Kyung Kim, Abbi D. Lane-Cordova, Jennifer Lewey, Lauren H. Theilen, George R. Saade, Philip Greenland, William A. Grobman
Summary: This study found a significant association between early pregnancy obesity and postpartum hypertension, hyperlipidemia, and diabetes risk. Adverse pregnancy outcomes were related to increased incidence of postpartum hypertension and hyperlipidemia. However, these adverse pregnancy outcomes only partially mediated the association between early pregnancy obesity and postpartum hypertension.
CIRCULATION RESEARCH
(2023)
Article
Obstetrics & Gynecology
Mara J. Dinsmoor, Lynda G. Ugwu, Jennifer L. Bailit, Uma M. Reddy, Ronald J. Wapner, Michael W. Varner, John M. Thorp, Steve N. Caritis, Mona Prasad, Alan T. N. Tita, George R. Saade, Yoram Sorokin, Dwight J. Rouse, Sean C. Blackwell, Jorge E. Tolosa
Summary: This study aimed to evaluate the impact of maternal obesity on neonatal outcomes. The results showed that pregnant women with morbid obesity had a higher risk of composite neonatal morbidity compared to the reference group.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Endocrinology & Metabolism
Tong Wei Yew, Claudia Chi, Shiao-Yng Chan, Rob M. van Dam, Clare Whitton, Chang Siang Lim, Pin Sym Foong, Winni Fransisca, Chieu Leng Teoh, Jeannie Chen, Su Tin Ho-Lim, Su Lin Lim, Kai Wen Ong, Peck-Hoon Ong, Bee Choo Tai, E. Shyong Tai
Summary: The study found that adding the Habits-GDM app to routine care improved maternal glycemic control and composite neonatal outcomes, but did not reduce excessive gestational weight gain among women with GDM.
Article
Medicine, General & Internal
Alice Ronco, Sofia Roero, Silvana Arduino, Arianna Arese, Isabella Ferrando, Gabriella Scaltrito, Viola Casula, Teresa Fea, Mattia Mazza, Carlotta Bossotti, Roberto Zizzo, Alberto Revelli
Summary: This study analyzed the specific effects of gestational diabetes mellitus (GDM) on twin pregnancy outcomes. The results showed that compared to GDM singleton pregnancies, GDM twins had higher rates of preeclampsia, cesarean section, and neonatal hypoglycemia. Compared to twin pregnancies without GDM, women with GDM twins were older, had higher BMI, had a higher incidence of large-for-gestational-age (LGA) newborns, and a lower incidence of low APGAR scores. Overall, GDM does not worsen outcomes of twin pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Suping Li, Qian Wang, Xin Tan, Linghua Wang, Jin Gong, Juan Zhang, Weilin Wang, Jiangling Liu
Summary: This study explored the potential association of neonatal/adult sepsis with several inflammation-related diseases in multiple physiological systems. The findings showed that neonatal sepsis was related to a decreased level of body mass index, and adult sepsis was related to a decreased risk of obesity. However, no association was found between sepsis and other inflammation-related diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Hiba J. Mustafa, Karl Seif, Ali Javinani, Faezeh Aghajani, Rachel Orlinsky, Maria Vera Alvarez, Amanda Ryan, Sarah Crimmins
Summary: This study systematically investigated obstetrical and neonatal outcomes related to gestational weight gain below the current guidelines for maternal obesity. Results showed benefits such as reduced rates of large for gestational age neonates, preeclampsia, and cesarean deliveries. Additionally, inadequate weight gain during pregnancy did not increase neonatal morbidity rates.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Article
Nutrition & Dietetics
Howaida Khair, Mo'ath F. Bataineh, Kornelia Zareba, Shamsa Alawar, Sara Maki, Gehan Sayed Sallam, Afra Abdalla, Sharon Mutare, Habiba I. Ali
Summary: This study aimed to explore the perception of weight, knowledge of healthy gestational weight gain, and weight-related pregnancy complications among pregnant Emirati women. The majority of participants entered pregnancy as overweight or obese, with underestimation of weight category being more common among overweight and obese participants. Awareness of weight-related pregnancy complications varied, and there was a misconception about personal BMI and appropriate gestational weight gain. It is crucial to incorporate healthy lifestyle counseling into preventative health programs for better maternal health.
Article
Immunology
Ruth Owen, Emily R. Thompson, Samuel J. Tingle, Ibrahim K. Ibrahim, Derek M. Manas, Steve A. White, Colin H. Wilson
Summary: This study investigated the impact of recipient BMI on graft outcomes after pancreas transplantation. It was found that increasing recipient BMI had a significant impact on graft survival, especially for recipients on dialysis with a BMI >30 kg/m(2). However, a specific cutoff value for BMI that could predict outcomes accurately was not identified.
Article
Endocrinology & Metabolism
Siok Siong Ching, Phong Ching Lee, Chin Hong Lim, Andrew Siang Yih Wong, Annalisa Ya-Lyn Ng, Jinlin Lin, June Lee
Summary: This study aimed to validate the recently introduced metric %AWL for comparing outcomes after laparoscopic sleeve gastrectomy (LSG) and Roux-en-Y gastric bypass (LRYGB). The weight data of patients who had undergone LSG and LRYGB were analyzed, and %EWL, %TWL, and %AWL metrics were used for comparing their weight loss. The findings suggest that %AWL is the best metric for medium-term comparison after LRYGB, while an intermediary metric based on BMI 8 kg/m(2) provides the best fit for LSG.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Eliza W. Kinsey, Elizabeth M. Widen, James W. Quinn, Mary Huynh, Gretchen Van Wye, Gina S. Lovasi, Kathryn M. Neckerman, Andrew G. Rundle
Summary: This study found that living in neighborhoods with higher levels of poverty was associated with greater odds of excessive gestational weight gain, while living in neighborhoods with higher walkability was associated with lower odds of excessive gestational weight gain. Adjusting for pre-pregnancy BMI attenuated the association with neighborhood poverty but not with walkability. Neighborhood characteristics were not associated with inadequate gestational weight gain.
Article
Endocrinology & Metabolism
Zhimin Song, Yan Cheng, Tingting Li, Yongfang Fan, Qingying Zhang, Haidong Cheng
Summary: This study analyzed pregnancy complications and outcomes in mothers with obesity or gestational diabetes mellitus (GDM). The results showed that both the obesity group and the GDM group had higher risks for various complications and adverse outcomes, including hypertensive disorders of pregnancy, preterm delivery, and fetal malformation. These findings indicate that obesity and GDM can have detrimental effects on maternal and fetal health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Jole Costanza, Margherita Camanni, Maria Maddalena Ferrari, Valentina De Cosmi, Silvia Tabano, Laura Fontana, Tatjana Radaelli, Giulia Privitera, Daniela Alberico, Patrizia Colapietro, Silvia Motta, Silvia Sirchia, Tamara Stampalija, Chiara Tabasso, Paola Roggero, Fabio Parazzini, Fabio Mosca, Enrico Ferrazzi, Silvano Bosari, Monica Miozzo, Carlo Agostoni
Summary: In a study of 503 women with uncomplicated pregnancies, maternal pre-pregnancy body mass index (BMI), gestational weight gain (GWG), and placental weight were found to be independently correlated with neonatal birth weight. However, maternal nutrition during pregnancy was not found to be associated with birth weight.
PEDIATRIC RESEARCH
(2022)
Review
Anesthesiology
Rimanatou Seyni-Boureima, Zongze Zhang, Malyn M. L. K. Antoine, Chrystal D. Antoine-Frank
Summary: There has been an increase in obesity prevalence, leading to higher occurrence of anesthesiology related complications in obese patients, necessitating effective management by anesthesiologists.
BMC ANESTHESIOLOGY
(2022)
Article
Multidisciplinary Sciences
Samantha M. McDonald, Steven Mouro, Breanna Wisseman, Christy Isler, James DeVente, Edward Newton, Jason Hildebrand, Devon Kuehn, George Kelley, Lisa Chasan-Taber, Nicholas T. Broskey, Linda E. May
Summary: Women with overweight or obesity have a higher risk of cesarean birth, preterm birth, and high birth weight infants. Regular exercise can decrease these risks in women with a healthy weight, but the association has not been thoroughly explored in overweight or obese women. This study found that pregnant women who exercised did not have a higher risk of cesarean birth, preterm birth, or high birth weight infants compared to those who didn't exercise. However, overweight or obese women who exercised had higher rates of cesarean birth and a trend towards higher rates of preterm birth, but their babies had a normal weight compared to normal weight exercisers.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Marshall F. Wilkinson, Tumul Chowdhury, W. Alan C. Mutch, Anthony M. Kaufmann
CLINICAL NEUROPHYSIOLOGY
(2015)
Article
Anesthesiology
Ryan Brinkman, Kent T. HayGlass, W. A. C. Mutch, Duane J. Funk
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2015)
Article
Surgery
Duane Funk, James Bohn, W. A. C. Mutch, Tom Hayakawa, Edward W. Buchel
Article
Anesthesiology
Alain Deschamps, Richard Hall, Hilary Grocott, C. David Mazer, Peter T. Choi, Alexis F. Turgeon, Etienne de Medicis, Jean S. Bussieres, Christopher Hudson, Summer Syed, Doug Seal, Stuart Herd, Jean Lambert, Andre Denault
Article
Neurosciences
James Duffin, Olivia Sobczyk, Adrian Crawley, Julien Poublanc, Lashmi Venkatraghavan, Kevin Sam, Alan Mutch, David Mikulis, Joseph Fisher
HUMAN BRAIN MAPPING
(2017)
Article
Anesthesiology
Ryan Brinkman, Ryan J. J. Amadeo, Duane J. Funk, Linda G. Girling, Hilary P. Grocott, W. Alan C. Mutch
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2013)
Editorial Material
Biology
W. Alan C. Mutch
PHYSICS OF LIFE REVIEWS
(2013)
Article
Multidisciplinary Sciences
W. Alan C. Mutch, Daniel M. Mandell, Joseph A. Fisher, David J. Mikulis, Adrian P. Crawley, Olivia Pucci, James Duffin
Article
Multidisciplinary Sciences
W. Alan C. Mutch, Sunni R. Patel, Ayda M. Shahidi, Susith I. Kulasekara, Joseph A. Fisher, James Duffin, Christopher Hudson
Article
Multidisciplinary Sciences
W. Alan C. Mutch, Michael J. Ellis, M. Ruth Graham, Vincent Wourms, Roshan Raban, Joseph A. Fisher, David Mikulis, Jeffrey Leiter, Lawrence Ryner
Letter
Anesthesiology
W. Alan C. Mutch, Renee M. El-Gabalawy, M. Ruth Graham
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2020)
Letter
Anesthesiology
W. Alan C. Mutch, M. Ruth Graham, Renee M. El-Gabalawy
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Critical Care Medicine
Reema Shafi, Julien Poublanc, Lashmi Venkatraghavan, Adrian P. Crawley, Olivia Sobczyk, Larissa McKetton, Mark Bayley, Tharshini Chandra, Evan Foster, Lesley Ruttan, Paul Comper, Maria Carmela Tartaglia, Charles H. Tator, James Duffin, W. Alan Mutch, Joseph Fisher, David J. Mikulis
Summary: This study focused on changes in blood flow metrics following concussion, finding that concussed participants showed greater magnitude and speed of response to a vasodilatory stimulus. White matter CVR metrics demonstrated higher classification accuracy based on gender.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Anesthesiology
W. Alan C. Mutch, James Duffin
Summary: Anesthesia leads to changes in end-tidal respiratory gases which result in vasoactive changes in regional cerebral blood flow. By using pCASL to compare vasoconstriction and vasodilation ratios, we can better understand the changes in cerebral blood flow during anesthesia and potentially identify individuals at risk of postoperative delirium.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Article
Critical Care Medicine
W. Alan C. Mutch, Renee El-Gabalawy, Lawrence Ryner, Josep Puig, Marco Essig, Kayla Kilborn, Kelsi Fidler, M. Ruth Graham