期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 25, 期 3, 页码 723-731出版社
SPRINGER
DOI: 10.1007/s10856-013-5113-0
关键词
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资金
- Natural Science Foundation of Guangdong [S2012040008003]
- Guangzhou Science and Technology Plan Project [11C32070752]
- DEGP [cxzd1109]
- Ph.D. Programs Foundation of Ministry of Education of China
- Fundamental Research Funds for the Central Universities [21612327]
Chitosan (CS) was first modified hydrophobically with deoxycholic acid (DCA) and then with polyethylene glycol (PEG) to obtain a novel amphiphilic polymer (CS-DCA-PEG). This was covalently bound to folic acid (FA) to develop nanoparticles (CS-DCA-PEG-FA) with tumor cell targeting property. The structure of the conjugates was characterised using Fourier transform infrared and H-1 nuclear magnetic resonance spectroscopy and X-ray diffraction. Based on self-aggregation, the conjugates formed nanoparticles with a low critical aggregation concentration of 0.035 mg/ml. The anti-cancer drug doxorubicin (DOX) was encapsulated into the nanoparticles with a drug-loading capacity of 30.2 wt%. The mean diameter of the DOX-loaded nanoparticles was about 200 nm, with a narrow size distribution. Transmission electron microscopy images showed that the DOX-loaded nanoparticles were spherical. The drug release was studied under different conditions. Furthermore, the cytotoxic activities of DOX in CS-DCA-PEG-FA nanoparticles against folate receptor (FR)-positive HeLa cells and FR-negative fibroblast 3T3 cells were evaluated. These results suggested that the CS-DCA-PEG-FA nanoparticles may be a promising vehicle for the targeting anticancer drug to tumor cells.
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