期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 24, 期 11, 页码 2549-2559出版社
SPRINGER
DOI: 10.1007/s10856-013-4981-7
关键词
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资金
- Shandong Provincial Natural Science Foundation, China [Y2008F15, ZR2012CM025]
- Scientific and Technological Development Project of Shandong Province [2012YD18063]
- Shandong Province Higher Educational Science, Technology Program [J11LF67]
- Health Department of Shandong Province [2011HZ115]
- Weifang Science and Technology Bureau Project [201232112]
The aim of this paper was to investigate the effect of carboxymethyl chitosan anti-adhesion solution on prevention of postsurgical adhesion. Forty adult male Wistar rats were randomly divided into three groups: 0.9 % normal saline solution (group A), hyaluronic acid gels (group B) and carboxymethyl chitosan anti-adhesion solution (group C). The animals were treated with normal saline, hyaluronic acid gels or carboxymethyl chitosan anti-adhesion solution at the time of surgery. After 2 or 3 weeks, the degree of adhesions and histological effects were determined. The adhesions in groups B and C were significantly decreased, and the levels of TGF-beta(1) and hydroxyproline in group C were significantly lower than that in group A (P < 0.05). The histopathology in group C showed fewer inflammatory cells and fibroblasts. Carboxymethyl chitosan anti-adhesion solution can effectively prevent postoperative adhesion which is a promising drug delivery system in the context of postsurgical anti-adhesion.
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