Article
Polymer Science
Eman Zmaily Dahmash, Dalia Khalil Ali, Hamad S. Alyami, Hussien AbdulKarim, Mohammad H. Alyami, Alhassan H. Aodah
Summary: Thymoquinone (TQ), the main active constituent of Nigella sativa, has shown broad-spectrum antimicrobial, antioxidant, and anti-inflammatory effects. However, its clinical use has been hindered by limited solubility and bioavailability. To overcome these limitations, a targeted delivery system using nanotechnology to deliver TQ to the lungs is needed.
Article
Polymer Science
Yosra Hadj Kacem, Abdelkader Bougarech, Guilhem Quintard, Souhir Abid, Majdi Abid, Etienne Fleury
Summary: A new class of materials based on crosslinked poly (ester-urethane) containing low proportions of ionic liquid were synthesized and characterized using various techniques. The study revealed that the degradation of the materials mainly depends on the content of ionic liquid and the degree of crosslinking.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Noor Mohammed Al-Baldawi, Dalia Khalil Ali, Qais Jarrar, Rasha Abuthawabeh, Eman Zmaily Dahmash
Summary: This study developed arginine-poly(esteramide) nanocapsules loaded with carbamazepine for direct brain drug delivery via the nose-brain transport pathway. The optimized formulation showed high entrapment efficiency, good loading efficiency, targeted release, and small particle size. In vivo study demonstrated the effective delivery of CBZ to the brain through nose-brain treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Tingwei He, Tao Liu, Junyao Huang, Xueli Wang, Yong He, Bomou Ma
Summary: A novel poly(ester amide)s (PEAs) was synthesized through melt polymerization, and the effects of polymerization temperature and time on its crystallization, thermal stability and amide transesterification were thoroughly investigated. The prepared PEAs were found to be semi-crystalline with melting point around 154-165 degrees C and decomposition temperature around 377-392 degrees C. The chemical structure of PEAs synthesized under different conditions was confirmed by H-1 NMR, C-13 NMR, and DEPT spectra, showing the occurrence of amide transesterification during the melt polymerization process.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Polymer Science
David M. Guptill, Bhavani Shankar Chinta, Trinadh Kaicharla, Shu Xu, Thomas R. Hoye
Summary: Poly(ester-amide)s (PEAs) were prepared by reacting MVL-derived diamidodiols with diacid chlorides in solution, resulting in materials with plastic properties. The stiffness of the materials can be tuned by choosing appropriate precursors. NMR studies were used to detect the degradation products of these materials.
Article
Polymer Science
Ban H. Al-Tayyem, Bassam A. Sweileh
Summary: Three bio-based isosorbide bis(acid ester)s were synthesized from isosorbide and cyclic anhydrides, and were then converted into diacid dichloride derivatives. These derivatives were used to design bio-based polyesters and poly(ester amide)s with a wide range of thermal properties. The polyesters showed high yields, good thermal stabilities, solubility in organic solvents, and glass transition temperatures ranging from -13.7 to 102.8 degrees C. Novel aliphatic poly(ester amide)s were also synthesized, exhibiting good thermal stabilities, solubility in organic solvents, and glass transition temperatures up to 129 degrees C.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Polymer Science
Chongrui Zhang, Yinmin Cai, Qiang Zhao
Summary: In this study, a positively charged poly(ionic liquid) with benzene rings in repeating units was designed to form fluidic coacervates when mixed with a like-charge poly(ionic liquid). The effects of polymer concentration, temperature, and ionic strength on the coacervate were investigated, and it was confirmed that the coacervate formation benefited from the cation-pi interaction. This work provides principles and understandings for designing coacervates derived from like-charge poly(ionic liquids) with high charge density.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Jianhua Zhang, Junfei Hu, Baoshu Chen, Tianbao Zhao, Zhipeng Gu
Summary: The PAA/PEA hybrid hydrogel dressing exhibits good antioxidant properties which can promote wound healing, support cell proliferation, and angiogenesis. Experimental results on mouse skin wounds demonstrate that the hybrid hydrogel scaffolds significantly accelerate the wound healing process, showing superior healing effects.
REGENERATIVE BIOMATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Hao Zhang, Fei Xie, Zhang Zhao, Noor Ul Afsar, Fangmeng Sheng, Liang Ge, Xingya Li, Xiwang Zhang, Tongwen Xu
Summary: Tuning the crosslinking density of interfacial-polymerized nanofiltration membranes can meet the demand of various applications. The properties of NF membranes can be tuned by choosing monomers with different structures and reactivities. PEA membranes with tunable crosslinked structures provide new possibilities for the development of task-specific separation membranes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Composites
T. Deepa, E. Bhakya Lakshmi, M. Kayalvizhi, A. Arun
Summary: Biodegradable polyurethane with excellent mechanical property has various applications in the biomedical field. In this study, a multi block copolymer poly(urethane-urea-amide) (PUUA) was successfully prepared using polyethylene oxide, 1,6-hexamethylene diisocyanate and diamide as monomers. The synthesized copolymers were characterized by various techniques including NMR spectroscopy, viscosity measurements, FT-IR, DSC, TGA, and biodegradability tests. The results showed that the 6T6 based polymer exhibited a high crystallinity of 70% and had a thermal stability up to 400 degrees C. The strain-induced crystallization in the PUUA was confirmed by the tensile test. The biodegradability of the copolymer depended on the pH and chain extenders. These findings suggest that this type of material is a promising candidate for tissue engineering applications.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2022)
Article
Polymer Science
Ge Zhu, Haoji Lao, Feng Feng, Minyan Wang, Xingzhong Fang, Guofei Chen
Summary: Two series of poly(amide imide)s (PAIs) were synthesized via thermal imidization using novel isomeric amide-containing diamine monomers and different commercial aromatic dianhydrides. These PAIs exhibited excellent thermal and mechanical properties, making them potential candidates for flexible displays. The effects of the isomeric monomers on film properties were compared.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Ge Zhu, Haoji Lao, Feng Feng, Minyan Wang, Xingzhong Fang, Guofei Chen
Summary: Two series of poly(amide imide)s (PAIs) with excellent high temperature performance, low coefficient of thermal expansion, and high mechanical properties were synthesized via thermal imidization. These PAIs have potential applications in flexible displays. The effects of different amide-containing diamine monomers on film properties were investigated.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Polymer Science
Taejoon Byun, Seong Jong Kim, Sang Youl Kim
Summary: Soluble aromatic poly(amide-imide)s with controlled imide/amide bond ratio were synthesized from a new diamide-diamine monomer. These materials exhibited high thermal stability and solubility, and could be used to fabricate flexible films.
Article
Chemistry, Applied
Annesha Kar, Muzamil Ahmad Rather, Manabendra Mandal, Niranjan Karak
Summary: Poly(ester amide urethane) resins were synthesized to overcome the shortcomings of poly(ester amide) and impart new features. The synthesized material showed excellent elongation, toughness, thermal stability, and chemical resistance. Aging tests proved their enhanced tensile strength parameters, making them suitable for outdoor applications. They also demonstrated good biodegradability and cytocompatibility.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Nanoscience & Nanotechnology
Yu Feng, Yingchun Li, Abdulraheem S. A. Almalki, Xiangning Meng, A. Alhadhrami, Xinming Ye, Mohamed M. Ibrahim, Xin Guo, Hassan Algadi, Mina Huang, William Winchester, Zhe Wang
Summary: A PBSeT copolyester was synthesized by introducing a polar amide unit into the molecular chain, which strengthened the material's mechanical properties and water vapor barrier, while maintaining its biodegradability.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)