期刊
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
卷 21, 期 6, 页码 1881-1890出版社
SPRINGER
DOI: 10.1007/s10856-010-4049-x
关键词
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资金
- National Natural Science Foundation of China [20674019, 20804015]
- Natural Science Foundation of Shanghai [08ZR1406000]
- Ministry of Education of China [20060251015, 200802511021]
- Shanghai Leading Academic Discipline Project [B502]
The macromonomer of 2-hydroxyethyl methyacrylate-caprolactone (HPCL) was synthesized by the ring-opening polymerization (ROP) of epsilon-caprolactone, which was initiated by 2-hydroxyethyl methyacrylate (HEMA). Then, the graft terpolymers of NIPAAm-co-AAc-co-HEMA-g-PCL (PHNA-CL) with varying mole ratios were subsequently synthesized by free radical polymerization of HEMA-PCL, N-isopropylacrylamide (NIPAAm) and acrylic acid (AAc). PHNA-CL was further self-assembled in different types of solvent. All the as-prepared copolymers were characterized by H-1 NMR, FT-IR and GPC. Micellization behaviors of micelles were studied by TEM and DLS. The micelles exhibited a phase transition temperature which can be readily adjusted by changing pH value of the micellization system. Micelle loaded with doxorubicin (DOX) was used to evaluate the drug release behavior. The release of DOX from micelles could be controlled by changing pH value and temperature in buffer solutions. The micelles are potentially to be used as a new anticancer drug carrier for intracellular delivery.
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