Article
Chemistry, Applied
Phuong Anh Dang, Carla Palomino-Durand, Mohamed Elsafi Mabrouk, Pierre Marquaille, Clement Odier, Sophie Norvez, Emmanuel Pauthe, Laurent Corte
Summary: This study presents a rational design of injectable thermosensitive chitosan systems for cell encapsulation and delivery using mixtures of two phosphate salts. The gelation kinetics can be finely tuned through adjusting pH and salt-glucosamine ratios. The formulations with physiological pH and osmolarity demonstrated a liquid state for over 2 hours at 20 degrees C and formed a porous gel within 2 minutes at 37 degrees C.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Ming Guan, Can Liu, Qiangqiang Zheng, Guangyu Chu, Hehui Wang, Jiale Jin, Honghao Wu, Jingyao Chen, Qiong Huang, Zexing Deng, Yue Wang
Summary: We found that disc degeneration is closely associated with nucleus pulposus (NP) cell senescence, and exosomes derived from mesenchymal stem cells (MSCs) can alleviate NP cell senescence and promote extracellular matrix (ECM) deposition. We developed an exosomes-laden hydrogel based on quaternized chitosan (QCS) and oxidized starch (OST) which showed injectability, self-healing properties, biocompatibility, and sustained release of exosomes. In a rat model of disc degeneration, the QCS-OST/Exos hydrogel rejuvenated NP cell senescence, promoted ECM remodeling, and partially restored the structures of NP and annulus fibrosis. Our findings suggest that the QCS-OST/Exos hydrogel is an effective therapeutic strategy for treating disc degeneration by alleviating NP cell senescence.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Multidisciplinary
Mithun Rajendra Dethe, A. Prabakaran, Hafiz Ahmed, Mukta Agrawal, Upal Roy, Amit Alexander
Summary: Stimuli-responsive hydrogels have been extensively studied in biomedical applications due to their biodegradability and biocompatibility. The emergence of in situ stimuli-responsive hydrogels is the result of advancements in synthetic chemistry and materials science. The copolymer PCL-PEG, recognized by the FDA, can form thermosensitive injectable hydrogels that exhibit rapid and reversible gelation behavior.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Barbara Canciani, Francesca Semeraro, Valentina Rafaela Herrera Millar, Francesca Gervaso, Alessandro Polini, Antonella Stanzione, Giuseppe Michele Peretti, Alessia Di Giancamillo, Laura Mangiavini
Summary: This study investigated the biocompatibility, both in vitro and in vivo, of a thermosensitive, injectable chitosan-based hydrogel loaded with three different types of primary mesenchymal stromal cells. The cells were encapsulated in the hydrogel and analyzed for survival and proliferation. In vivo, the cell-laden hydrogels were implanted in nude mice and assessed over a period of 12 weeks. The results showed that the hydrogel formulation had a favorable safety and biocompatibility profile, making it a potential candidate for tissue engineering strategies in cartilage and meniscus repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Xiaoshuang Yu, Can Cheng, Xu Peng, Kaixuan Zhang, Xixun Yu
Summary: In this study, a multifunctional hydrogel was successfully prepared by modifying guar gum with quaternization and oxidation, showing properties such as antibacterial, hemostatic, self-repairing, and injectable capabilities. The hydrogel exhibited excellent biocompatibility and demonstrated potential in promoting wound healing in a rat wound model infected with S. aureus.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Yunwei Niu, Jiahe Wu, Yanxiang Kang, Pingli Sun, Zuobing Xiao, Di Zhao
Summary: Magnetic chitosan hydrogels are a type of organic-inorganic composite material that combines the characteristics of magnetic materials and natural polysaccharides. These hydrogels, which are made by adding magnetic nanoparticles to chitosan, have improved mechanical strength and exhibit magnetic thermal effects, targeting capabilities, magnetically-sensitive release characteristics, and easy separation and recovery. They have been used in various applications including drug delivery, magnetic resonance imaging, mag-netothermal therapy, and adsorption of heavy metals and dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
Yukun Du, Jianyi Li, Xiaojie Tang, Yingying Liu, Guoshuai Bian, Jianzhuang Shi, Yixin Zhang, Baomeng Zhao, Hongri Zhao, Kunyan Sui, Yongming Xi
Summary: This study successfully synthesized a thermosensitive injectable celecoxib-loaded chitosan hydrogel and demonstrated its good biocompatibility and repair effect in vitro and in vivo experiments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lin Zhao, Zhipan Feng, Yang Lyu, Jueying Yang, Lizhi Lin, Haochen Bai, Yujing Li, Yongqiang Feng, Yu Chen
Summary: An electroactive hydrogel was constructed by rapidly forming dynamic imine bonds between oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS), and in situ forming silver nanoparticles (AgNPs) by UV irradiation. The hydrogel exhibited injectability, self-healing ability, biocompatibility, and antibacterial activities. It promoted cell proliferation and accelerated wound healing in a skin defect model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
AmirHossein Bahmanpour, Maryam Ghaffari, Peiman B. Milan, Fathollah Mortarzadeh, Masoud Mozafari
Summary: The study focused on developing a novel formulation for intranasal insulin delivery using chitosan, HTCC, and Gel, which demonstrated low gelation time, uniform pore structure, and desirable swelling rate for adequate encapsulation and prolonged release of insulin within 24 hours. The optimal samples released 65% of the total amount of insulin in the first 24 hours, showing favorable results for the study.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Julia Ohmes, Lena Marie Saure, Fabian Schuett, Marie Trenkel, Andreas Seekamp, Regina Scherliess, Rainer Adelung, Sabine Fuchs
Summary: In this study, an injectable thermosensitive hydrogel was developed for the delivery of fucoidan and MSC for use in regenerative medicine. The hydrogel exhibited good physicochemical properties and biocompatibility, and was able to release fucoidan over a certain period of time.
Article
Pharmacology & Pharmacy
Minoo Ghanavi, Ali Khoshandam, Shaghayegh Aslzad, Marziyeh Fathi, Abolfazl Barzegari, Elaheh Dalir Abdolahinia, Khosro Adibkia, Jaleh Barar, Yadollah Omidi
Summary: Due to the unique structure of the human eye, ocular drug delivery faces challenges such as low bioavailability. In-situ gel-forming mucoadhesive hydrogels can improve ocular bioavailability. Chitosan has been used in the preparation of these hydrogels. Water-soluble chitosan was obtained and gel formation was accomplished using sodium beta-glycerophosphate and sodium bicarbonate. The prepared hydrogel showed sustained-release and antibacterial activity in vitro.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Polymer Science
Kamla Pathak, Shashi Kiran Misra, Aayush Sehgal, Sukhbir Singh, Simona Bungau, Agnieszka Najda, Robert Gruszecki, Tapan Behl
Summary: Chitosan, a natural polymer, is extensively used for versatile drug delivery systems, with quaternized chitosan being preferred in pharmaceutical industries due to its superior properties. Quaternized chitosan has been widely applied in tissue engineering, wound healing, gene, and vaccine delivery.
Article
Chemistry, Applied
Pengpeng Deng, Lichao Yao, Juanjuan Chen, Zhigang Tang, Jinping Zhou
Summary: AC hydrogels can accelerate wound healing, with self-healing, low swelling rate, biocompatibility, and excellent hemostatic effect. They also show outstanding antibacterial activity and can be used for designing multifunctional dressings.
CARBOHYDRATE POLYMERS
(2022)
Review
Polymer Science
Ruixi Ye, Siyu Liu, Wenkai Zhu, Yurong Li, Long Huang, Guozheng Zhang, Yeshun Zhang
Summary: The potential applications of chitosan-based hydrogels (CBHs) in biomedical fields such as tissue engineering, wound healing, drug delivery, and biosensing have attracted great interest. The synthesis and characterization methods used to create CBHs play a crucial role in determining their properties and effectiveness. Tailoring the manufacturing process can greatly influence the qualities of CBHs, including porosity, swelling, mechanical strength, and bioactivity. Characterization methods are also important in understanding the microstructures and properties of CBHs. This review provides a comprehensive assessment of the current state-of-the-art, focusing on the relationship between specific properties and biomedical domains. It also highlights the beneficial properties and wide application of stimuli-responsive CBHs, as well as discussing the main obstacles and future prospects for CBH development in biomedical applications.
Article
Biophysics
Yin Xiao, Yuhong Gu, Li Qin, Lin Chen, Xiaoliang Chen, Weiheng Cui, Fuling Li, Ni Xiang, Xiaoai He
Summary: Injectable thermosensitive hydrogel is an attractive drug delivery system that has become increasingly important in cancer therapy due to its ability to provide high local drug concentration, sustained release, minimal invasiveness, and low systemic toxicities. This review highlights its extensive application in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Lingchong Wang, Yujia Wu, Junsong Li, Hongzhi Qiao, Liuqing Di
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Engineering, Environmental
Haifeng Zhang, Qifeng Dang, Chengsheng Liu, Dejun Yu, Yan Wang, Xiaoying Pu, Yan Liu, Yuanyuan Liang, Dongsu Cha
JOURNAL OF HAZARDOUS MATERIALS
(2019)
Article
Pharmacology & Pharmacy
Ruoning Wang, Jiawei Han, Ai Jiang, Rong Huang, Tingming Fu, Lingchong Wang, Qin Zheng, Wen Li, Junsong Li
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Yujia Wu, Wen Zhang, Jianyu Huang, Zichen Luo, Junsong Li, Lingchong Wang, Liuqing Di
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Pharmacology & Pharmacy
Lingchong Wang, Ying Yang, Hor-Yue Tan, Sha Li, Yibin Feng
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Chemistry, Applied
Ying Yang, Jing Ji, Liuqing Di, Junsong Li, Lihong Hu, Hongzhi Qiao, Lingchong Wang, Yibin Feng
CARBOHYDRATE POLYMERS
(2020)
Article
Pharmacology & Pharmacy
Bingqian Zhou, Wen Zhang, Yujia Wu, Ying Yang, Na Wang, Junsong Li, Tingming Fu, Lingchong Wang, Liuqing Di
Summary: The study improved the encapsulation rate of PNS by packaging it into BSP/alginate microspheres, whose release characteristics aligned with the Weibull equation, releasing active ingredients through diffusion and erosion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biophysics
Yutong Wang, Huaning Li, Lingchong Wang, Jiawei Han, Yujie Yang, Tingming Fu, Hongzhi Qiao, Zengwu Wang, Junsong Li
Summary: The study utilized nanocrystals technology to fabricate silybin nanocrystals, which were then loaded into mucoadhesive microspheres to enhance retention time in the gastrointestinal tract and improve drug bioavailability. The developed delivery system showed high encapsulation efficiency and drug loading capacity, with mucoadhesive microspheres demonstrating excellent retention properties in ex vivo tests. Additionally, the drug release percentage and oral bioavailability were significantly improved compared to unprocessed silybin, highlighting the potential of nanocrystals technology in enhancing drug delivery systems.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Jing Ji, Wenwen Huang, Lingchong Wang, Lu Chen, Yuanqing Wei, Rui Liu, Jianming Cheng, Hao Wu
Summary: The study showed that iowaite is effective in removing arsenic from marine products, especially inorganic arsenic. However, the adsorption of organic arsenic from marine samples by iowaite is limited, indicating the need for further research on its performance in this aspect.
Article
Pharmacology & Pharmacy
Yutong Wang, Jinyu Huang, Zilin Wang, Xitong Wang, Heng Liu, Xiangwei Li, Hongzhi Qiao, Lingchong Wang, Jing Chen, Xiao Chen, Junsong Li
Summary: This study demonstrated that the EVOO-based phospholipid complex/self-microemulsion greatly enhanced the oral absorption of SAB, mainly attributed to the inhibition of COMT activity induced by EVOO.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hongqing Cheng, Xiaoshun Jia, Dandan Yuan, Huaning Li, Lingchong Wang, Tingming Fu, Hongzhi Qiao, Jing Chen, Zengwu Wang, Xiaobing Cui, Jianming Cheng, Junsong Li
Summary: This study introduces a new excipient-free nanodispersion method to enhance the water solubility of hydrophobic aglycone drugs. Molecular dynamics simulations indicate that both hydrophobic interactions and hydrogen-bond interactions contribute to the formation of nanodispersions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Food Science & Technology
Lihua Chen, Junsong Li, Xiaolin Bi, Jing Ji, Lingchong Wang, Jianming Cheng
Summary: Calcium citrate and chondroitin sulfate were transformed into edible granules by spray-drying and polymer coating. These granules, embedded with calcium and oligochitosan, were found to inhibit osteoporosis progression and enhance bone density in animal tests.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Chemistry, Multidisciplinary
Jiayu Xie, Dapeng Zhang, Cheng Liu, Lingchong Wang
Summary: Tubiechong, a traditional Chinese medicine, has been historically used for treating bruises, fractures, and amenorrhea. Chemical studies indicate that it contains active compounds such as proteins, amino acids, and peptides, with a wide range of activities including anti-coagulation, anti-tumor, and antioxidant properties. Its traditional medical use and modern pharmacological actions suggest potential applications in disease treatment, particularly in anticancer practices.
Review
Chemistry, Multidisciplinary
Lingchong Wang, Dapeng Zhang, Ning Wang, Sha Li, Hor-Yue Tan, Yibin Feng
Review
Food Science & Technology
Ling Chong Wang, Liu Qing Di, Jun Song Li, Li Hong Hu, Jian Ming Cheng, Hao Wu
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2019)