Article
Biochemistry & Molecular Biology
Katarina Vdoviakova, Andrej Jenca, Andrej Jenca Jr, Jan Danko, Lenka Kresakova, Veronika Simaiova, Peter Reichel, Pavol Rusnak, Jozef Pribula, Marko Vrzgula, Sarah J. Askin, Maria Giretova, Jaroslav Briancin, Lubomir Medvecky
Summary: Reconstruction and restoration of bone defects in the mandible remains a challenge in maxillofacial surgery. Innovative biomaterials, such as hydroxyapatite ceramics, show promise in regenerative medicine. Our study evaluated the regenerative potential of hydroxyapatite ceramic implants in the cortical bone of the lower jaw in pigs, using the tape-casting method. Results confirmed the positive regenerative potential of these ceramic implants in treating mandible bone defects.
Article
Engineering, Biomedical
Said K. Taha, Elham A. Hassan, Sahar Mousa, Gehan T. El-Bassyouni, Heba N. Shalash, Mohamed Abdel A. Hamid
Summary: The present study evaluated the osteogenic potential and biocompatibility of combining biphasic calcium phosphate with zirconia nanoparticles for mandibular defect reconstruction. The combination (4Zr TCP/HA) showed improved physicochemical, morphological, and bactericidal properties. In vivo application in dogs demonstrated increased bone density and bone area percentage compared to the control group. Doping with zirconia resulted in significant increase in bone formation and maturation compared to TCP/HA group.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ho-Kyung Lim, Ik-Jae Kwon, Sung-Woon On, Seok-Jin Hong, Byoung-Eun Yang, Soung-Min Kim, Jong-Ho Lee, Soo-Hwan Byun
Summary: The study investigated the bone regeneration capacity of BCP powder, BCP block, and BCP collagen with different concentrations of rhBMP-2 in an animal model. Results showed that increasing rhBMP-2 concentration did not significantly enhance osteogenesis, while collagen-added material may help mediate rapid bone formation in initial stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Hao-Yu Chang, Wei-Hsing Tuan, Po-Liang Lai
Summary: The study reports the characteristics of a novel biphasic bone graft composed of calcium sulfate (CS) and hydroxyapatite (HA) with two degradation rates. Most of the bone graft degraded after 13 weeks of implantation, replaced by trabecular bone and vascular tissue at the implant site. The biphasic bone graft is unique for its burst of calcium ions at the beginning and its stable porous structure ideal for new bone formation and vascularization.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Rasha A. Youness, Mohammed Said Amer, Mohammed A. Taha
Summary: This study aimed to improve the performance of biphasic calcium phosphate (BCP) for bone replacement applications. By adding zirconia (ZrO2), the nanocomposites exhibited enhanced tribological and mechanical properties, with reduced particle sizes. The implanted nanocomposite also demonstrated excellent bioactivity.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Franciska Oberdiek, Carlos Ivan Vargas, Patrick Rider, Milijana Batinic, Oliver Goerke, Milena Radenkovic, Stevo Najman, Jose Manuel Baena, Ole Jung, Mike Barbeck
Summary: The study evaluated a composite material of PCL and BCP fabricated via fused deposition modeling in terms of its ex vivo and in vivo properties. Results showed no significant differences in mechanical properties between PCL and PCL + BCP, with good biocompatibility observed for both scaffolds. Additionally, all materials demonstrated osteoconductive properties, with the BCP group showing the highest new bone formation in the calvaria model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Shahrokh Hatefi, Milad Sh Etemadi, Javad Alizargar, Venous Behdadipour, Khaled Abou-El-Hossein
Summary: The application of Distraction Osteogenesis (DO) techniques in reconstruction surgeries is advantageous with fewer side effects. However, the development of automatic devices for controlled continuous force still requires further research. A two-axis continuous distractor is proposed for mandibular reconstruction, meeting the current requirements.
BIOENGINEERING-BASEL
(2022)
Article
Biotechnology & Applied Microbiology
Carlo Mangano, Alessandra Giuliani, Ilaria De Tullio, Mario Raspanti, Adriano Piattelli, Giovanna Iezzi
Summary: The study evaluated a case of bone regeneration using a 30%HA-60%beta-TCP BCP 3D-printed scaffold, with clinical and histological results after 7 years, showing the effectiveness of BCP scaffolds for bone regeneration. Results demonstrated complete integration and preservation of correct bone tissue structure with the 3D printed scaffold.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Dong Zhang, Xiaoshuang Guo, Xianlei Zong, Hong Du, Jingyi Zhao, Le Du, Chunyan Cao, Xiaolei Jin, Guodong Song
Summary: Different microstructures of biphasic calcium phosphate ceramics were obtained by varying sintering temperatures. BMSCs showed different degrees of proliferation when co-cultured with BCPs. Implantation of BCPs with different micropore diameters in muscles of beagle dogs promoted osteogenesis and differentially regulated Notch signaling pathway genes.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Materials Science, Ceramics
Yun-Hee Lee, Ji-Won Lee, Seo-Young Yang, Hyun Lee, Young Hag Koh, Hyoun-Ee Kim
Summary: This study introduces a novel type of biphasic calcium phosphate (BCP) gyroid scaffolds with unique structure and microporous walls, produced using PMMA microspheres as porogen for ceramic manufacturing technique. By controlling the PMMA content, the microporosity of the BCP walls and the overall porosity of the scaffolds were adjusted, resulting in high overall porosity while maintaining reasonable compressive strength.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Physical
Anton Friedmann, Stefan Fickl, Kai R. Fischer, Milad Dalloul, Werner Goetz, Frederic Kauffmann
Summary: This study compared the effects of different graft/membrane combinations on bone formation and found that collagen membranes with prolonged resorption/barrier profile combined with bone substitutes featuring different degradation profiles are sufficient to support new bone formation, and tacking strategy/membrane fixation is not necessary.
Article
Dentistry, Oral Surgery & Medicine
Mariane B. Sordi, Raissa B. Curtarelli, Iara F. Mantovani, Anderson C. Moreira, Celso P. Fernandes, Ariadne C. C. Cruz, Ricardo S. Magini
Summary: The study showed that embedding simvastatin in PLGA + HA/β-TCP scaffolds significantly enhanced the osteoinductive capacity of the scaffolds. The release profile of simvastatin was sustained over time, reaching 40% drug release at day 28. Scaffold with simvastatin promoted the highest osteogenic differentiation of SHED compared to control groups.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lara Schorn, Tim Fienitz, Maximilian F. Gerstenberg, Anja Sterner-Kock, Alexandra C. Maul, Julian Lommen, Henrik Holtmann, Daniel Rothamel
Summary: The study found that different carrier materials influence BCP-induced bone regeneration. The BCP alone group showed the lowest rate of new bone formation, while the BCP + C group exhibited the highest percentage of new bone formation. Additionally, the BCP + C group had the least residual bone substitute material after 8 weeks.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Oncology
Lauren N. Ruger, Alayna N. Hay, Elliana R. Vickers, Sheryl L. Coutermarsh-Ott, Jessica M. Gannon, Hannah S. Covell, Gregory B. Daniel, Paul F. Laeseke, Timothy J. Ziemlewicz, Katharine R. Kierski, Brittany J. Ciepluch, Eli Vlaisavljevich, Joanne L. Tuohy
Summary: This study demonstrates the safety and feasibility of histotripsy ablation in canine patients with osteosarcoma, showing extensive tissue destruction and distinguishable radiographic changes in the tumor. It significantly expands our understanding of histotripsy for bone tumor ablation.
Article
Cell & Tissue Engineering
S. Sebastian, F. Tandberg, Y. Liu, D. B. Raina, M. Taegil, M. Collin, L. Lidgren
Summary: This in vitro study evaluated a biphasic calcium sulphate/hydroxyapatite biomaterial as a carrier for dual delivery of rifampicin with vancomycin or gentamicin. The results showed that the composite material exhibited good injectability and setting time, with sustained release of rifampicin and antibiotics. It demonstrated excellent antibacterial and antibiofilm effects against Staphylococcus aureus strains.
BONE & JOINT RESEARCH
(2022)
Article
Engineering, Multidisciplinary
Hao Zhu, Havard Jostein Haugen, Giuseppe Perale, Janne Elin Reseland, Liebert Parreiras Nogueira, Antonio Gonzalez Cantalapiedra, Fernando Maria Guzon Munoz, Maria Permuy Mendana, Felice Betge, Stale Petter Lyngstadaas, Jun Xiao
Summary: The study demonstrates that gelatins from different sources can be successfully used in designing xeno-hybrid bone grafts, showing positive effects on bone regeneration and providing solutions for optimizing bone resorption and regeneration balance.
Article
Materials Science, Multidisciplinary
Maryam Rahmati, Sabine Stoetzel, Thaqif El Khassawna, Chenyi Mao, Adilijiang Ali, Joshua C. Vaughan, Kamila Iskhahova, D. C. Florian Wieland, Antonio Gonzalez Cantalapiedra, Giuseppe Perale, Felice Betge, Eoghan P. Dillon, Stale Petter Lyngstadaas, Havard Jostein Haugen
Summary: Biomaterial scientists have designed organic bone substitutes based on the biochemical properties of the tissue they mimic, aiming to achieve similar functionality. In this study, two proline-rich disordered peptides (P2 and P6) were incorporated into a biohybrid substitute called SmartBone (R) (SBN). The results showed that these peptides can stimulate bone formation and biomineralization, with P6 being more effective in the early stages while P2 had a stronger effect on later processes. Furthermore, the use of various analysis techniques proved to be valuable in evaluating and diagnosing the structure of bone tissue and the bone-biomaterial interface.
Article
Clinical Neurology
Joseph L. Laratta, Bradley J. Vivace, Monica Lopez-Pena, Fernando Munoz Guzon, Antonio Gonzalez-Cantalpeidra, Alberto Jorge-Mora, Rosa Maria Villar-Liste, Laura Pino-Lopez, Alexandr Lukyanchuk, Erik Arden Taghizadeh, Jesus Pino-Minguez
Summary: By comparing the osseointegration of 3D-pTi interbody cages and PEEK interbody cages with autologous iliac crest bone graft in an ovine model, this study found that the 3D-pTi cages demonstrated superior osseointegration at 4 and 8 weeks postoperatively, indicating early and robust bone fusion potential without the need for bone grafts or osteoinductive agents. This could have significant clinical implications for lumbar fusion surgeries and especially benefit patients with spinal neoplasms.
Article
Dentistry, Oral Surgery & Medicine
Niklaus P. Lang, Jean-Claude Imber, Kiri N. Lang, Bruno Schmid, Fernando Munoz, Dieter D. Bosshardt, Nikola Saulacic
Summary: This study evaluated the sequential osseointegration of a novel titanium implant system based on 3D printing technology compared to conventional titanium implants. Two novel implants based on 3D printing and two different commercially available titanium implants were tested in the mandible of Beagle dogs. The results showed that the novel titanium implants had a higher bone-to-implant contact percentage, while the commercially available implants had a higher percentage of new mineralized bone. The study concluded that the novel titanium implant system based on 3D printing technology had satisfactory osseointegration.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Daniel Alves, Ricardo Faria-Almeida, Alvaro Azevedo, Antonio Linares, Fernando Munoz, Juan Blanco-Carrion
Summary: This study evaluated the soft tissue healing after immediately placed one-piece zirconia implant with xenograft grafting into the buccal gap. The results showed that the marginal mucosa was positioned coronally on the test side, indicating less soft tissue recession compared with the control side. Therefore, the gap size may have a modifying effect on the application of this protocol.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jean-Claude Imber, Andrea Roccuzzo, Alexandra Stahli, Dieter D. Bosshardt, Fernando Munoz, Christoph A. Ramseier, Niklaus P. Lang, Anton Sculean
Summary: The aim of this study was to investigate the spontaneous regeneration of the implanto-mucosal and dento-gingival unit after complete removal of keratinized tissue (KT). The results showed that at implant sites, the spontaneous regeneration of soft tissue was characterized by a non-keratinized epithelium typical for alveolar mucosa, while at tooth sites, the spontaneous regeneration resembled gingiva.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Orthopedics
Miquel Antich-Rossello, Maria Antonia Forteza-Genestra, Hans Jacob Ronold, Staale Petter Lyngstadaas, Mario Garcia-Gonzalez, Maria Permuy, Monica Lopez-Pena, Fernando Munoz, Marta Monjo, Joana M. Ramis
Summary: This study evaluated the translational potential of platelet derived extracellular vesicles (pEV) for bone healing applications by using hyaluronic acid (HA) gels formulated with pEVs. The results showed that pEV HA treated implants decreased the necrotic effects of the surgery and diminished the fibrotic response associated with implant encapsulation at the bone-implant interface.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Engineering, Biomedical
Ivan Alonso-Fernandez, Havard Jostein Haugen, Monica Lopez-Pena, Antonio Gonzalez-Cantalapiedra, Fernando Munoz
Summary: This study systematically reviewed the feasibility of using PLA/bioceramic composite scaffolds manufactured by 3D-printing technologies as bone grafting materials in preclinical in vivo studies. The results showed that PLA/bioceramic composite scaffolds are biocompatible and mechanically resistant, allowing bone growth without adverse reactions. However, the lack of standardization in the experimental processes makes it difficult to compare the results, reducing the quality of the information.
ACTA BIOMATERIALIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jean-Claude Imber, Andrea Roccuzzo, Alexandra Stahli, Dieter D. Bosshardt, Fernando Munoz, Christoph A. Ramseier, Niklaus P. Lang, Anton Sculean
Summary: The findings of this study indicate that transpositioned keratinized tissue can retain its morphological characteristics, and transpositioned non-keratinized tissue results in the formation of keratinized tissue at tooth sites but not at implant sites.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jean-Claude Imber, Larissa Carmela Imber, Andrea Roccuzzo, Alexandra Stahli, Fernando Munoz, Jens Weusmann, Dieter Daniel Bosshardt, Anton Sculean
Summary: This study evaluates the potential of a novel synthetic carbonate apatite bone substitute (CO3Ap-BS) for periodontal regeneration.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Antonio Linares, Raul Verdeja, Benjamin Pippenger, Fernando Munoz, Monica Lopez-Pena, Juan Blanco
Summary: A new preclinical model was developed to study early implant loss. The results showed that implants placed in a pre-contaminated site had a higher risk of early loss compared to implants placed in a non-contaminated site. This model provides an effective tool to study the mechanisms and reduction of early implant loss.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Veterinary Sciences
Victoria Valino-Cultelli, Oscar Varela-Lopez, Antonio Gonzalez-Cantalapiedra
Summary: This study investigated the incidence of patellar desmopathy in dogs that underwent MMT and evaluated the effects of PRGF on ligament inflammation. The results showed that the desmopathy produced by MMT is similar to that caused by TTA if the pin is carefully placed. Additionally, PRGF did not reduce ligament inflammation and thickening.
VETERINARY SCIENCES
(2022)