Article
Biophysics
Xiaoming Qiu, Songkai Li, Xun Li, Yating Xiao, Shengtang Li, Qiangsheng Fen, Xuewen Kang, Ping Zhen
Summary: Antibiotic bone cement filling technology has been widely used in the treatment of infectious bone defects. However, the current treatment is complicated and burdensome for patients. In this study, a composite scaffold was developed to effectively repair infectious bone defects, showing promising antibacterial and osteogenic abilities in animal models.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Polymer Science
Woo-Shik Jeong, Young-Chul Kim, Jae-Cheong Min, Ho-Jin Park, Eun-Ju Lee, Jin-Hyung Shim, Jong-Woo Choi
Summary: In this study, the efficacy of a 3D-printed, patient-specific polycaprolactone/beta tricalcium phosphate scaffold in the treatment of complex zygomatico-maxillary defects was evaluated. The results demonstrated satisfactory volume conformity and bone formation, indicating the potential of this technique to replace traditional implants in the future.
Article
Chemistry, Physical
Kuo-Sheng Hung, May-Show Chen, Wen-Chien Lan, Yung-Chieh Cho, Takashi Saito, Bai-Hung Huang, Hsin-Yu Tsai, Chia-Chien Hsieh, Keng-Liang Ou, Hung-Yang Lin
Summary: In this study, a 3D printed porous scaffold composed of β-TCP and F-127 was proposed for bone defect treatment. The scaffold demonstrated well-defined porosity, excellent microstructural interconnectivity, and acceptable wettability. It also exhibited good cell viability and attachment behavior. The scaffold with a pore size of around 350 μm showed the highest bone formation volume and can provide proper loading support for bone regeneration.
Article
Materials Science, Ceramics
Mengna Duan, Sijia Ma, Chunyan Song, Jie Li, Ming Qian
Summary: This study proposed a novel method to enhance the antibacterial and osteoinduction capabilities of β-TCP scaffolds by immobilising BMP2-MP and OS through mimicking a mussel adhesion mechanism. The introduction of the DOPA tail significantly improved the binding capability of BMP2-MP and OS with the scaffold, thus enhancing its performance in critical-sized bone defect repair.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Chuanchuan Zheng, Shokouh Attarilar, Kai Li, Chong Wang, Jia Liu, Liqiang Wang, Junlin Yang, Yujin Tang
Summary: The study demonstrates that the scaffold loaded with HA15 can promote osteoblast differentiation, repair rabbit bone defects, and promote blood vessel regeneration. HA15 targets HSPA5 to inhibit endoplasmic reticulum stress, ultimately promoting osteogenesis, bone regeneration, and angiogenesis.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Engineering, Biomedical
Su A. Park, Hyo-Jung Lee, Sung-Yeol Kim, Keun-Suh Kim, Deuk-Won Jo, Shin-Young Park
Summary: In this study, 3D-printed scaffolds with a ratio of polycaprolactone and beta-tricalcium phosphate were used as carriers for rhBMP-2 in mandibular bone defect models. The results showed that PCL/T50 scaffolds were advantageous for rhBMP-2 delivery and maintaining space for bone formation in mandibular bone defects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Biochemistry & Molecular Biology
Julien Guerrero, Ekaterina Maevskaia, Chafik Ghayor, Indranil Bhattacharya, Franz E. Weber
Summary: This study utilized additive manufacturing to produce two different diameter tricalcium phosphate-based bone scaffolds and observed them in vivo for 10 days followed by gene sequencing and histological analysis. The results showed upregulation of genes related to immune response, cell adhesion, and cell migration in both scaffolds. However, only the scaffold with a 0.50mm diameter showed significant overexpression of genes involved in angiogenesis, cell differentiation regulation, ossification, and bone development. Immunohistochemistry and high-resolution CT scans also revealed more blood vessels and mineralized tissue in the 0.50mm scaffold. Therefore, different filament diameters significantly influence angiogenesis and cell differentiation regulation in the early phase of bone regeneration, impacting the overall clinical outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xu Chen, Chun-Yan Gao, Xiao-Yang Chu, Chun-Yan Zheng, Ying-Yi Luan, Xin He, Kai Yang, Dong-Liang Zhang
Summary: This study synthesized a HG-HA-TCP scaffold loaded with VEGF, which showed good biocompatibility and mechanical properties. The results demonstrated that the scaffold could promote the proliferation, migration, and adhesion of stem cells, as well as enhance osteogenic differentiation and vascularization. In vivo experiments showed that the scaffold improved new bone regeneration and increased bone mineral density. This study is of great importance for bone tissue engineering and developing new clinical treatment strategies for bone tissue defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Ceramics
C. Ruiz-Aguilar, U. Olivares-Pinto, I Alfonso
Summary: In this study, six different compositions of β-TCP scaffolds were produced using sodium chloride as a porogen at varying concentrations. The scaffolds showed promising physical, chemical, mechanical, and in vitro properties, with the formation of new crystalline phases and favorable bioactivity observed.
CERAMICS INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Liangjie Lu, Huihan Wang, Minjie Yang, Lijun Wang, Kaifeng Gan
Summary: A functional MoS2/PDA/-BMP2-IGF-1 coating was successfully constructed on a beta-TCP scaffold, and the resulting MPBI@beta-TCP exhibited enhanced osteogenic activity and biocompatibility. It promoted the adhesion, diffusion, and proliferation of MSCs, and stimulated the secretion of VEGF in endothelial cells. Under NIR laser irradiation, MPBI@beta-TCP demonstrated a photothermal effect that effectively killed osteosarcoma cells and enhanced bone regeneration in vivo. This work highlights the potential of 3D-printed MPBI@beta-TCP in tissue defect applications.
Article
Materials Science, Ceramics
ZhiDong Lin, XuLin Hu, LiLun Zhong, DeQiang Peng, JunLin Lu, Jian He, Xiaofei Shen, ChengDong Xiong, Tao Xu, Wei Niu
Summary: By adding PVA, we successfully improved the printability of TCP paste, maintained the excellent forming ability and printing precision of the scaffolds, and showed similar compressive strength and distinct micropores on the surfaces of the scaffolds with different concentrations of PVA after sintering. Differences in the microstructure significantly facilitated the adhesion of bone marrow mesenchymal stem cells to scaffolds, making the methods provided promising for application in 3D printing techniques.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Li-li Wang, Cheng-yuan Tian, Li-na Feng, Xiao-he He, Zhi-cheng Zhao
Summary: Hydroxyapatite (HA) has gained attention as a drug carrier due to its excellent biocompatibility and bioactivity. However, its poor biodegradability, low drug loading, and uncontrollable release rate limit its application. In this study, a composite of HA and tricalcium phosphate (beta-TCP) was prepared using the co-precipitation template method with different Ca/P ratios. The composite showed better drug loading performance and slower release rates compared to pure-phase HA. The composite with a Ca/P ratio of 1.5 exhibited the highest adsorption capacity and cumulative release rate for the drug, making it a potential candidate for controlled drug release.
Article
Biophysics
Jian He, Zhidong Lin, Xulin Hu, Luyao Xing, Gaofeng Lian, Dongliang Chen, Junling An, Chengdong Xiong, Xiangchun Zhang, Lifang Zhang
Summary: The study developed bioactive scaffolds with favorable mechanical properties and osteogenesis promotion, which could be a promising alternative to bone cement in bone tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Materials Science, Multidisciplinary
C. Ruiz-Aguilar, L. Gaytan-Tocaven, R. G. Paredes
Summary: Beta-TCP is a promising bioceramic with similar composition to bones and teeth, which stimulates the formation of bone tissue. It can be used in various ways in the human body, mainly for the regeneration and stimulation of cortical and trabecular bone tissue. In a skull implant experiment on rats, the beta-TCP scaffold showed excellent bioactivity, stimulating new bone formation without affecting the animals' motor and cognitive abilities.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Materials Science, Multidisciplinary
Arjak Bhattacharjee, Susmita Bose
Summary: This study utilizes a Zn2+-curcumin complex from a fluoride doped hydroxyapatite matrix to inhibit osteosarcoma, promote osteoblast growth, and provide antibacterial properties. The drug delivery system shows significant enhancement in cell viability and osteosarcoma inhibition, and exhibits antibacterial efficacy against Staphylococcus aureus. This multifunctional system has potential applications in bone tissue engineering and dental fields.
JOURNAL OF MATERIALS RESEARCH
(2022)