Review
Cardiac & Cardiovascular Systems
Rachel E. Climie, Jordi Alastruey, Christopher C. Mayer, Achim Schwarz, Agne Laucyte-Cibulskiene, Julija Voicehovska, Elisabetta Bianchini, Rosa-Maria Bruno, Peter H. Charlton, Andrea Grillo, Andrea Guala, Magid Hallab, Bernhard Hametner, Piotr Jankowski, Karsten Konigstein, Anna Lebedeva, Ioana Mozos, Giacomo Pucci, Houry Puzantian, Dimitrios Terentes-Printzios, Gunay Yetik-Anacak, Chloe Park, Peter M. Nilsson, Thomas Weber
Summary: Prevention of cardiovascular disease (CVD) is a major public health challenge. Identifying individuals at increased cardiovascular risk at an asymptomatic stage is crucial for minimizing disease progression and burden. Vascular ageing (VA) is the deterioration of vascular structure and function over time and can help identify those at elevated cardiovascular risk. However, VA is seldom measured in routine clinical practice due to lack of consensus and practical issues. This state-of-the-art review aims to increase knowledge about VA and promote its routine measurement.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Editorial Material
Oncology
Francisco Hermida-Prado, Rinath Jeselsohn
Summary: ESR1 ligand-binding mutations, the most common genetic mechanism of acquired resistance to endocrine treatment, lead to constitutive ligand-independent activity, emerging under the selective pressure of aromatase inhibitors. New models of these mutations have been generated using CRISPR technology, shedding light on their functional consequences.
Article
Physiology
Margaret Gilfillan, Vineet Bhandari
Summary: BPD is a complex multifactorial condition primarily caused by disturbances in the regulation of normal pulmonary development. There are still significant knowledge gaps in developing effective therapeutic strategies for BPD that need to be addressed through further research.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Review
Hematology
Allistair A. Abraham, John F. Tisdale
Summary: Gene therapy holds promise as a potential cure for sickle cell disease, with advancements in genome sequencing and molecular tools enabling gene modification of hematopoietic stem cells. Despite hurdles such as stem cell collection and gene expression levels, discovery of genome editors has enhanced the safety and efficacy of gene therapy. The progress to clinical trials has been supported by optimizing gene-addition strategies and addressing challenges such as patient conditioning and specialized facilities for gene modification.
Review
Cell Biology
Ludi Yang, Xiang Gu, Jie Yu, Shengfang Ge, Xianqun Fan
Summary: Oncolytic viruses, either natural or genetically engineered, can replicate in tumor cells and inhibit tumor growth, making them an effective anticancer strategy. Their multifunctional characteristics suggest promising application prospects in cancer therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Health Care Sciences & Services
Changwon Wang, Chungkeun Lee, Hangsik Shin
Summary: As a new therapeutic technique based on digital technology, the commercialization and clinical application of digital therapeutics (DTx) are increasing. However, the lack of consensus on a definition, insufficiencies in research and development, clinical trials, standardization of regulatory frameworks, and technological maturity have made the use of DTx as a general medical component ambiguous. This study investigates definitions, clinical trials, commercial products, and regulatory status related to DTx and suggests the necessity and considerations for international agreements on the definition and characteristics of DTx, focusing on commercialization characteristics.
NPJ DIGITAL MEDICINE
(2023)
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fang, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs) are emerging catalytic nanomaterials with enzyme-like activities, which hold great promise in medical applications. This article presents the recent developments of SANs in anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Article
Hematology
Sangeetha Venugopal, Justin Watts
Summary: The discovery of IDH1 mutations in AML and the success of molecularly targeted therapies led to the development of IDH1mut inhibitors. Olutasidenib, a novel IDH1mut inhibitor, showed promising results in treating patients with R/R IDH1mut AML, including durable remission rates and transfusion independence. This review examines the development and positioning of olutasidenib in the treatment of IDH1mut AML.
Review
Chemistry, Physical
Chanyuan Jin, Sanjun Fan, Zechao Zhuang, Yongsheng Zhou
Summary: Single-atom nanozymes (SANs), a new type of catalytic nanomaterials with enzyme-mimetic activities, have gained extensive research attention in the fields of chemistry, energy conversion, and environmental purification. Recent studies have demonstrated the great potential of SANs in biological applications, including anti-infective treatment, cancer diagnosis and therapy, biosensing, and antioxidative therapy.
Review
Medicine, Research & Experimental
Miao Wang, Jie Rao, Meng Wang, Xiaosong Li, Kaili Liu, Mark F. Naylor, Robert E. Nordquist, Wei R. Chen, Feifan Zhou
Summary: The combination of targeted therapy and immunotherapy is considered an ideal strategy for treating metastatic cancer, with phototherapy emerging as a promising targeted therapy that can initiate antitumor immune responses through induced immunogenic tumor cell death. The use of phototherapy in conjunction with immunoadjuvant therapy has shown to induce a systemic antitumor immune response, controlling residual tumor cells at the treatment site and distant metastases.
Article
Medicine, Research & Experimental
Lauren T. May, Belinda A. Bartolo, David G. Harrison, Tomasz Guzik, Grant R. Drummond, Gemma A. Figtree, Rebecca H. Ritchie, Kerry-Anne Rye, Judy B. de Haan
Summary: Cardiovascular disease remains the leading cause of death worldwide. Developing novel pharmacotherapies, especially for treating atherosclerosis, is a challenge. It requires a deep understanding of the biological mechanisms underlying atherosclerosis and optimization of drug discovery methods. Current animal models do not fully replicate human atherosclerosis, but they remain crucial for evaluating pharmacological interventions when their advantages and limitations are properly understood.
Article
Engineering, Biomedical
Hatice B. Bingol, Johan C. M. E. Bender, Joost A. Opsteen, Sander C. G. Leeuwenburgh
Summary: Biodegradable bone adhesives are highly sought-after biomaterials that can replace traditional metallic devices for bone fixation. However, these biomaterials must meet numerous requirements, and commercially available bone-adhesive biomaterials that fulfill all of these requirements are currently not available. This comprehensive review provides an extensive overview of the development of bone adhesives from a translational perspective, highlighting the definition, classification, and chemistry of various types of bone adhesives. The review also focuses on materials capable of gluing two pieces of bone together within a time frame of minutes to days and critically reflects on commonly employed adhesion tests and the current state-of-the-art in their preclinical and clinical applicability.
MATERIALS TODAY BIO
(2023)
Review
Psychiatry
Julian Cheron, Alban de Kerchove d'Exaerde
Summary: Drug addiction causes millions of deaths per year worldwide, but misconceptions from the general public shadow its management as a chronic disease. Drug consumers are often stigmatized, leading to addiction being viewed as an individual issue rather than a societal one.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Zita Szentkereszty-Kovacs, Krisztian Gaspar, Andrea Szegedi, Lajos Kemeny, Dora Kovacs, Daniel Torocsik
Summary: This review discusses the impact of alcohol on psoriatic patients, linking clinical observations with molecular background and providing insights on how this knowledge could influence treatment selection and patient management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Shijie Duan, Shuhang Wang, Lei Qiao, Xinbo Yu, Nan Wang, Liting Chen, Xinyuan Zhang, Xu Zhao, Hongyu Liu, Tianye Wang, Ying Wu, Ning Li, Funan Liu
Summary: With advancements in cancer biology and molecular virology, oncolytic virus-driven therapies have emerged as a promising alternative to traditional cancer treatments. However, current clinical trials have shown limited efficacy when using a single oncolytic virus. Integrated approaches combining immunotherapy, chemotherapy, or radiotherapy with oncolytic virus therapy have shown considerable effectiveness. Challenges in oncolytic virus therapy include restricted delivery and poor targeting. Further optimization of delivery methods is needed before oncolytic viruses can become a viable tumor treatment option.
Review
Chemistry, Multidisciplinary
Yuan Xiong, Qian Feng, Li Lu, Kangkang Zha, Tao Yu, Ze Lin, Yiqiang Hu, Adriana C. C. Panayi, Vahideh Nosrati-Ziahmagi, Xiangyu Chu, Lang Chen, Mohammad-Ali Shahbazi, Bobin Mi, Guohui Liu
Summary: Diabetic foot ulcer (DFU) is a common complication of diabetes, and the lack of efficient therapy poses challenges for patients. Immunomodulatory hydrogels offer potential solutions for DFU treatment. This review comprehensively discusses recent advances in the fabrication and regenerative use of hydrogels for altering the immune microenvironment of DFUs. It also explores the potential of hydrogels for multimodal therapy and improved efficacy and safety.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Tianhe Huang, Guan Wang, Mohammad-Ali Shahbazi, Yuancheng Bai, Jingrui Zhang, Guobing Feng, Elham Asadian, Fatemeh Ghorbani-Bidkorpeh, Zhiyuang Yang, Yuanai Li, Qingqing Huo, Yingxin Liu, Dongfei Liu
Summary: A versatile surface decoration strategy has been developed to efficiently encapsulate water-soluble peptides and improve their pharmacokinetic features. By assembling peptide molecules into nanoparticles and decorating the surface with charged amino acid-grafted polymer layer, the phase transfer of peptide nanoparticles is controlled and the encapsulation efficiency is over 96%.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mahsa Sedighi, Zahra Mahmoudi, Alireza Ghasempour, Mehdi Shakibaie, Fahimeh Ghasemi, Mahsa Akbari, Samin Abbaszadeh, Ebrahim Mostafavi, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: Inspired by natural resources, glycopolypeptide biopolymers have emerged as a new form of biopolymers in biomedical applications. They have well-defined secondary structures and pendant glycosides, and the ability to self-assemble into diverse structures. The nanostructures of glycopolypeptides have opened up new perspectives in drug delivery, diagnosis, and regenerative medicine due to their stable three-dimensional structures, high drug loading efficiency, excellent biocompatibility, and biodegradability.
JOURNAL OF CONTROLLED RELEASE
(2023)
Editorial Material
Chemistry, Multidisciplinary
Helder A. Santos, Irina N. N. Savina
Summary: Professor Helder A. Santos and Dr. Irina N. Savina introduce the themed collection on Nanomaterials in drug delivery in RSC Advances.
Article
Engineering, Biomedical
Chiara Tramontano, Joao Pedro Martins, Luca De Stefano, Marianna Kemell, Alexandra Correia, Monica Terracciano, Nicola Borbone, Ilaria Rea, Helder A. Santos
Summary: A nanoparticle-based drug delivery system has been developed for oral administration, which targets colorectal cancer cells and enhances drug efficacy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Physical
Voitto Kankanen, Micaela Fernandes, Zehua Liu, Jani Seitsonen, Sami-Pekka Hirvonen, Janne Ruokolainen, Joao F. Pinto, Jouni Hirvonen, Vimalkumar Balasubramanian, Helder A. Santos
Summary: This study reports the development of poly(ethylene glycol)-block-(e-caprolactone) (PEG-b-PCL) nanoparticles using a microfluidic technique for intravenous drug delivery. The optimized formulation achieved spherical morphology, small particle size (dH < 80 nm), uniform size distribution (PDI < 0.2), high drug loading degree (16%), and encapsulation efficiency of 54%. Furthermore, the nanoparticles exhibited stability and sustained release of sorafenib in vitro over several days. Overall, this research demonstrates the use of microfluidic approach in optimizing drug delivery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Guoqiang Zhong, Liudi Wang, Hong Jin, Xinying Li, Dong Zhou, Guoying Wang, Ruixian Lian, Peng Xie, Shihao Zhang, Ling Zheng, Xue Qu, Shurong Shen, Mohammad-Ali Shahbazij, Lan Xiao, Kaichun Li, Jie Gao, Yulin Li
Summary: In this study, a tumor microenvironment pH and enzyme double-responsive shrinkable nanoparticle, called LDC, was developed to address the issues of uncontrolled drug release, limited tumor penetration, and poor stability in nanoparticle-based delivery systems. LDC has a size of 100 nm and contains stable anticancer medication DOX, which efficiently accumulates in tumors. The presence of lysozymes in the tumor extracellular matrix degrades COS and releases smaller DOX-containing nanoparticles, causing LDC to shrink to 30 nm and facilitate deep tumor penetration.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sanaz Mehdi-Alamdarlou, Fatemeh Ahmadi, Mohammad-Ali Shahbazi, Amir Azadi, Hajar Ashrafi
Summary: Multiple sclerosis (MS) is a progressive inflammatory autoimmune disease that often occurs in young individuals. Current drug delivery systems for MS have limited efficacy due to the low concentration of drugs in the central nervous system (CNS) caused by the blood-brain barrier (BBB). Therefore, innovative active targeted drug delivery methods are critical for effective treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Engineering, Biomedical
Jiachen Li, Shiqi Wang, Flavia Fontana, Christos Tapeinos, Mohammad -Ali Shahbazi, Huijie Han, Helder A. Santos
Summary: Remarkable progress has been made in phototherapy in recent decades, thanks to its non-invasiveness and immediate therapeutic effectiveness. Moreover, the development of nanoparticle-based phototherapy systems has emerged as a hot topic in nanomedicine research, especially in cancer. This review briefly introduces the history and mechanisms of phototherapy, summarizes the recent development in nanoparticle-based phototherapy, highlights the innovative design of nanoparticles, and discusses the potential of these systems in clinical anticancer therapy.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Samin Abbaszadeh, Mohammad Reza Eskandari, Vahideh Nosrati-Siahmazgi, Kiyan Musaie, Soraya Mehrabi, Ruikang Tang, Mohammad Reza Jafari, Bo Xiao, Vahid Hosseinpour Sarmadi, Fakhri Haghi, Bo Zhi Chen, Xin Dong Guo, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: To improve the efficiency of intravenously administered nanocarriers in tumor eradication, researchers have developed an injectable hydrogel that can enhance viscosity and self-heal at the tumor site. The hydrogel contains cancer cell membrane and sorafenib to elicit immune responses and induce cancer cell apoptosis, as well as hyaluronic acid coated Bi2S3 nanorods for prolonged local photothermal therapy. The hydrogel promotes immunostimulatory responses and can completely ablate breast tumors in animal models. Additionally, the hydrogel exhibits strong antibacterial activity, reducing the risk of infection in post-cancer lesions formed by photothermal therapy.
MATERIALS TODAY BIO
(2023)
Review
Biochemistry & Molecular Biology
Alireza Ghasempour, Hamideh Dehghan, Mehrnaz Ataee, Bozhi Chen, Zeqiang Zhao, Mahsa Sedighi, Xindong Guo, Mohammad-Ali Shahbazi
Summary: Cadmium sulfide nanoparticles (CdS NPs) are widely used in nanobiotechnology due to their unique properties and have applications in biosensors, bioimaging, and antibacterial and anticancer applications. Biogenic synthesis is a preferred method for producing CdS NPs due to its efficiency, environmental friendliness, and biocompatibility. The size and coating of CdS NPs play a crucial role in their biomedical activities, and there is a need for further in vivo studies to reduce toxicity. This review discusses synthesis methods, characterization, and applications of CdS NPs in the biomedical field.
Review
Materials Science, Biomaterials
Ze Qiang Zhao, Ling Liang, Li Yue Jing, Yue Liu, Yu Han Zhang, Mohammad-Ali Shahbazi, Bo Zhi Chen, Xin Dong Guo
Summary: Wound management is a global concern that imposes a significant social and economic burden. Microneedles, a novel transdermal drug delivery method, can enhance wound-healing efficacy by overcoming barriers and improving drug delivery efficiency. This article reviews the research on the application of microneedles in wound management, categorizing them into five areas: hemostasis, antibacterial effects, proliferation, anti-scar, and wound monitoring. It concludes with a discussion on the current state and future direction of microneedles in wound management to inspire more efficient strategies.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Kiyan Musaie, Samin Abbaszadeh, Vahideh Nosrati-Siahmazgi, Mostafa Qahremani, Shige Wang, Mohammad Reza Eskandari, Seyyed Vahid Niknezhad, Fakhri Haghi, Yulin Li, Bo Xiao, Mohammad-Ali Shahbazi
Summary: Photothermal therapy (PTT) is a promising cancer treatment approach, but it can lead to local lesions and bacterial infection. To address these challenges, a strategy of mild PTT following high-temperature tumor ablation was studied, using a hydrogel for combined tumor suppression, wound healing, and bacterial eradication. Bi2S3 nanorods (NRs) coated with hyaluronic acid were employed as a photothermal agent, loaded into a Fe3+-coordinated hydrogel composed of sodium alginate (Alg) and Farsi gum (FG). The hydrogel showed excellent blood clotting effect and antimicrobial activity, and achieved efficient photothermal-based tumor eradication and accelerated wound healing in vivo.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Mozhgan Keshavarz, Mohammadjavad Jahanshahi, Masoud Hasany, Firoz Babu Kadumudi, Mehdi Mehrali, Mohammad-Ali Shahbazi, Parvin Alizadeh, Gorka Orive, Alireza Dolatshahi-Pirouz
Summary: Significant progress has been made in tissue engineering, but challenges remain. Bioprinting is an innovative technology that can help overcome these challenges. The new trend is 4D bioprinting, which allows printed constructs to change shape and function over time. Alginate, a key material, plays a crucial role in advancing bioprinting.
MATERIALS TODAY BIO
(2023)
