Article
Nanoscience & Nanotechnology
Xiaojuan Zhang, Pengfei Wei, Zhao Wang, Yuan Zhao, Wenke Xiao, Yong Bian, Dong Liang, Qing Lin, Wenli Song, Wei Jiang, Huan Wang
Summary: This study presents a synthesis of a diagnosis and therapy integration nanocarrier for magnetic resonance imaging-guided breast cancer-targeted chemotherapy. The nanocarrier, Fe3O4/P(NIPAM-AA-MAPEG) nanogels (MNLs), was prepared using in situ loading of doxorubicin (DOX) by miniemulsion polymerization. The MNLs showed excellent stability in a physiological environment and could be disrupted in an acidic environment to release the loaded drug. The dual-targeted pH-responsive nanogels demonstrated enhanced therapeutic effects and potential advantages in magnetic resonance imaging (MRI) for breast cancer diagnosis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyu Wang, Qing Ma, Chaochao Wen, Tao Gong, Jing Li, Wenting Liang, Meining Li, Yuyao Wang, Rui Guo
Summary: The novel nano-drug carrier constructed in this study showed good stability and blood compatibility, successfully loaded a hydrophobic anti-cancer drug, and demonstrated excellent liver cancer targeting therapy efficacy.
Article
Medicine, Research & Experimental
Shugo Yamashita, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
Summary: The aim of this study was to develop a new drug carrier for the treatment of bone diseases using a polyethylene glycol (PEG)-conjugated polyamidoamine dendrimer (PAMAM). The results showed that the carrier could efficiently target the osteoid surfaces and exhibit excellent performance in bone pathogenesis mechanisms.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Suresh Thangudu, Ching-Yi Tsai, Wei-Che Lin, Chia-Hao Su
Summary: In this study, a modified Gefitinib drug was successfully synthesized and conjugated to iron oxide nanoparticles for the treatment of non-small cell lung cancer. The drug delivery system exhibited excellent anticancer effects in vitro and the nanoparticles accumulated in tumor-specific regions in vivo, inhibiting cell growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Tianqi Zhao, Mingwei Zhou, Ronghui Wu, Huaxin Wang, Christos C. Zouboulis, Mingji Zhu, Myongsoo Lee
Summary: In this study, a novel isotretinoin delivery model for the treatment of skin diseases was developed using a self-assembly strategy. The model showed remarkable controlled release and high therapeutic efficacy in acne models with minimal skin irritation. It is a safe and effective formulation for treating patients with skin disorders.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wojciech G. Lesniak, Babak Behnam Azad, Samit Chatterjee, Ala Lisok, Martin G. Pomper
Summary: This study describes the formulation and pharmacokinetics of generation-5 CXCR4-targeted PAMAM dendrimers, as well as their applications in tumors. The results demonstrate the beneficial effects of CXCR4 targeting for tumor accumulation, but also highlight the increasing impact of passive accumulation over time.
Article
Chemistry, Multidisciplinary
Ahmaduddin Khan, Niroj Kumar Sahu
Summary: Nanoparticle-mediated drug delivery systems have significant therapeutic applications in cancer therapy, especially when combined with thermal therapies. Functionalized magnetic nanoparticles with preferred magnetic parameters are crucial for hyperthermia-enhanced chemotherapy.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yasuaki Anami, Wei Xiong, Aiko Yamaguchi, Chisato M. Yamazaki, Ningyan Zhang, Zhiqiang An, Kyoji Tsuchikama
Summary: Antibody-based therapy has achieved great success in treating various diseases, including cancers. However, the therapeutic efficacy of antibodies for central nervous system (CNS) diseases is limited by the low permeability of the blood-brain barrier (BBB). This study demonstrates that homogeneous conjugation of the synthetic BBB shuttle peptide Ang2 to a monoclonal antibody improves its binding affinity for brain microvascular endothelial cells and accumulation in normal brain tissues. In a mouse model, the homogeneous anti-EGFR mAb-Ang2 conjugate efficiently accumulates in intracranial tumors when administered intravenously. These findings suggest that homogeneous conjugation of BBB shuttle peptides like Ang2 is a promising approach to enhance the therapeutic efficacy of antibody agents for CNS diseases.
Article
Chemistry, Physical
Rohit Y. Sathe, Prasad Bharatam
Summary: This review highlights the importance and current status of dendritic nanovectors-based drug delivery, including key steps such as drug encapsulation and target-specific delivery, as well as advancements in experimental and computational techniques.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Nanoscience & Nanotechnology
Boddu Adilakshmi, Obireddy Sreekanth Reddy, Duddekunta Hemalatha, Kummari S. V. Krishna Rao, Wing-Fu Lai
Summary: Site-specific drug delivery systems using PEG as carriers have been widely adopted due to its favorable features. The development of carriers for hydrophobic anticancer agents remains a challenge. The developed drug conjugate PEGDA-MN-DOX shows anticancer potential, cancer-targeting ability, and ROS-generating capacity for effective drug encapsulation and sustained release in chemotherapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Wathsala Liyanage, Tony Wu, Sujatha Kannan, Rangaramanujam M. Kannan
Summary: In this study, covalently conjugated PAMAM dendrimer-siRNA conjugates have been developed, overcoming obstacles such as the blood-brain barrier, brain tissue penetration, and targeting of specific cells in siRNA delivery, offering a promising approach for clinical translation of RNAi therapies.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
T. Sagir, M. Huysal, M. Senel, S. Isik, N. Burgucu, O. Tabakoglu, M. Zaim
Summary: Novel folate-receptor-targeted polyamidoamine (PAMAM) dendrimer functional mesoporous silica-coated magnetic nanoparticles were prepared for drug delivery in photodynamic therapy. The nanoparticles showed efficient photodynamic therapy effect on MCF-7 cells, causing apoptosis.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Qianhua Peng, Xianling Guo, Yan Wang
Summary: In this study, a magnetically guided delivery system of cabazitaxel-loaded dendritic supramolecular iron oxide nanomaterials was used to examine the tumour regression efficiency in syngeneic C57BL/6 mice models with subcutaneous craniofacial melanoma. The results showed that the nanomaterials had a minor impact on physiological parameters and were mainly accumulated in the spleen, liver, and lungs. The magnetically targeted tumours had considerably higher localization than non-targeted tumours, leading to significant regression and complete disappearance of the tumour, resulting in a high survival rate.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Werner Tegge, Giulia Guerra, Alexander Hoeltke, Lauritz Schiller, Ulrike Beutling, Kirsten Harmrolfs, Lothar Groebe, Hannah Wullenkord, Chunfa Xu, Herbert Weich, Mark Broenstrup
Summary: A novel conjugation strategy was explored to make potent antibiotics more selective by accumulating the drug and releasing it triggered by infection. Bacterial targeting was achieved using a modified fragment of a human antimicrobial peptide, and the release of the drug was limited to infection-related situations through a linker cleaved by neutrophil elastase. The antibacterial efficacy of the conjugates was successfully demonstrated in co-cultures of human neutrophils and Escherichia coli.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Songbo Zhao, Jiazhi Duan, Yalin Lou, Ruyun Gao, Shanshan Yang, Piming Wang, Chunhua Wang, Lin Han, Minghuan Li, Chunhong Ma, Xiaohong Liang, Hong Liu, Yuanhua Sang, Lifen Gao
Summary: A novel immunotherapy approach utilizing NK cells conjugated with magnetic nanoparticles has been developed for treating solid tumors, demonstrating improved tumor targeting and inhibition capabilities through magnetic field guidance.
Article
Nanoscience & Nanotechnology
Maxim B. Prigozhin, Peter C. Maurer, Alexandra M. Courtis, Nian Liu, Michael D. Wisser, Chris Siefe, Bining Tian, Emory Chan, Guosheng Song, Stefan Fischer, Shaul Aloni, D. Frank Ogletree, Edward S. Barnard, Lydia-Marie Joubert, Jianghong Rao, A. Paul Alivisatos, Roger M. Macfarlane, Bruce E. Cohen, Yi Cui, Jennifer A. Dionne, Steven Chu
NATURE NANOTECHNOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Jianming Yu, Chao Wang, Shiheng Li, Nian Liu, Jia Zhu, Zhenda Lu
Article
Engineering, Biomedical
Yansong Feng, Haoran Chen, Yanni Wu, Ivo Que, Filippo Tamburini, Fabio Baldazzi, Yulei Chang, Hong Zhang
Article
Biophysics
Nian Liu, Hongsen Liu, Haoran Chen, Gang Wang, Haolin Teng, Yulei Chang
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Chemistry, Analytical
Nansong Zhu, Xiaolei Guo, Shirui Pang, Yulei Chang, Xiaomin Liu, Zhan Shi, Shouhua Feng
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Haoran Chen, Fengxia Wu, Xiaoyu Xie, Wang Wang, Qiqing Li, Langping Tu, Bin Li, Xianggui Kong, Yulei Chang
Summary: The study developed a theranostic nanoplatform that combines treatment and diagnosis functions through photoswitchable lanthanide-doped nanoparticles to achieve real-time imaging and PDT/chemotherapy treatment. Furthermore, the incorporation of additional functionalities enhanced the therapeutic effect, indicating potential application value in tumor treatment.
Article
Chemistry, Physical
Jing Zuo, Wei Wang, Dongxu Zhang, Xikun Wang, Yanling Ma, Peitong Li, Yifan Li, Wen Sun, Youlin Zhang, Langping Tu, Yulei Chang, Qiqing Li, Hong Zhang
Summary: Water-sensitive detection is important in various fields. This study demonstrates a high level of water sensitivity using a novel nanophosphor, providing a new strategy for nanophosphor-based sensors.
APPLIED SURFACE SCIENCE
(2022)
Article
Materials Science, Biomaterials
Fengxia Wu, Haoran Chen, Ruiqi Liu, Yongkuan Suo, Qiqing Li, Youlin Zhang, Hongguang Liu, Zhen Cheng, Yulei Chang
Summary: The development of a novel ferroptosis inducer BFA nanoplatform enhances the efficacy of ferroptosis therapy by increasing the Fenton reaction rate. The nanoplatform can generate high heat and hydroxyl radicals under near-infrared induction, inducing ferroptosis and serving as a photothermal agent to directly eliminate cancer cells.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyu Xie, Qiqing Li, Haoran Chen, Wang Wang, Fengxia Wu, Langping Tu, Youlin Zhang, Xianggui Kong, Yulei Chang
Summary: Increasing the concentration of sensitized rare-earth ions in a rational design upconversion nanostructure can combat the concentration quenching effect and improve the efficiency of multiphoton upconversion luminescence. The proposed host-sensitized nanostructure achieved the highest efficiency by optimizing the spatial distribution of the active ions, leading to better performance for FRET-based applications.
Article
Engineering, Biomedical
Fengxia Wu, Haoran Chen, Ruiqi Liu, Yongkuan Suo, Qiqing Li, Youlin Zhang, Hongguang Liu, Zhen Cheng, Yulei Chang
Summary: This study develops a second near-infrared (NIR-II) photothermal-nanocatalyst by decorating Bi2Te3 nanosheets with ultrasmall Au/Pd bimetallic nanoparticles (Bi2Te3-Au/Pd). The nanocatalyst can reverse the immunosuppressive tumor microenvironment (TME) by modulating the redox balance and relieving hypoxia, thereby enhancing ferroptosis. Additionally, the nanocatalyst-mediated cancer therapy can directly ablate cancer cells and inhibit tumor growth, metastasis, and recurrence.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Yulei Chang, Haoren Chen, Xiaoyu Xie, Yong Wan, Qiqing Li, Fengxia Wu, Run Yang, Wang Wang, Xianggui Kong
Summary: Fluorescence imaging in the near-infrared region is enhanced by the use of a Tm3+ -based nanoprobe for NIR-IIb/c imaging that provides references for future bioimaging above 1700nm. The study presents a type of thulium (Tm) self-sensitized rare-earth-doped nanocrystals (RENCs) fluorescence probe that emits bright downshifting luminescence at 1600-2100 nm for in vivo bioimaging. The results suggest that Tm-based NPs as NIR-IIb/c nanoprobes offer new opportunities for future applications in diverse fields.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Xinyu Dai, Yiping Liu, Fanrong Meng, Qiqing Li, Fengxia Wu, Jianguo Yuan, Haoran Chen, Huixin Lv, Yanmin Zhou, Yulei Chang
Summary: This study describes the development of a rational designed multifunctional photothermocatalytic agents for synergistic antibiofilm treatment of periodontitis, using near-infrared-II light. The treatment resulted in the generation of reactive oxygen and nitrogen species, damaging the biofilm and effectively eliminating periodontitis. This synergistic therapeutic strategy shows promise for clinical treatment of periodontitis.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Inorganic & Nuclear
Shengnan Liu, Jiahong Han, Weijin Wang, Yulei Chang, Runlin Wang, Ziwei Wang, Guangzhe Li, Dongxia Zhu, Martin R. Bryce
Summary: Photodynamic therapy (PDT) is a promising cancer treatment method, but traditional photosensitizers have limitations. By designing and synthesizing AIE-active Ir(III) complexes, researchers have addressed these limitations and demonstrated the potential of this approach.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Shengnan Liu, Jiahong Han, Yulei Chang, Weijin Wang, Runlin Wang, Ziwei Wang, Guangzhe Li, Dongxia Zhu, Martin R. Bryce
Summary: The integration of AIE-active Ir(III) complex and UCNPs has resulted in a promising NIR-irradiated photosensitizer UCNPs@Ir-2-N, which shows excellent performance in killing mouse cancer cells and has potential for future applications in photodynamic therapy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Wang Wang, Zhe Feng, Bai Li, Yulei Chang, Xu Li, Xu Yan, Runze Chen, Xiaoming Yu, Huiying Zhao, Geyu Lu, Xianggui Kong, Jun Qian, Xiaomin Liu
Summary: The research team developed an efficient NIR-IIb nanoprobe Er3+ self-sensitized NaErF4:0.5%Tm3+@NaLuF4, which significantly enhanced the 1525 nm emission efficiency for high-resolution imaging and in vivo physiological dynamic imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
