Review
Chemistry, Multidisciplinary
Tugba Acar, Kuebra Nur Cimen, Elif Ozalp, Oeznur Ilica, Esma Ahlatcioglu Ozerol
Summary: Biosensors have a significant role in the medical field due to their stability, selectivity, sensitivity, reproducibility, and linearity. Conducting polymers (CPs), with their electrical conductivity and easy synthesis and processing, are utilized to enhance biosensor properties. CPs, as organic materials, possess electrical and optical properties, as well as biocompatibility, thermal stability, and environmental stability. This review provides a comprehensive analysis of biosensors based on conductive polymers and their biomedical applications, highlighting the importance of conductive polymer-based biosensors in biomedicine.
Article
Polymer Science
Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Masoomeh Yari Kalashgrani, Navid Omidifar, Sonia Bahrani, Neralla Vijayakameswara Rao, Aziz Babapoor, Ahmad Gholami, Wei-Hung Chiang
Summary: Nanomedicine seeks to develop new polymer composites, such as bioactive GQD-based polymer composites, to address current challenges in diagnosing and treating common diseases, especially cancer. These polymer composites have a wide range of applications, including drug delivery, gene delivery, and bioimaging.
Article
Materials Science, Biomaterials
Luxing Wei, Yuan Li, Xiaoyong Qiu, Xiaolai Zhang, Xiaoyu Song, Yunpeng Zhao, Qing Yu, Jinlong Shao, Shaohua Ge, Jun Huang
Summary: This article develops an underwater stable, durable, and substrate-independent gelatin composite hydrogel (GMP) coating, which shows great potential for biomedical applications in the field of medical devices.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Hui Chen, Huimin Zhang, Tiantian Xu, Jiangfan Yu
Summary: Micronanoswarms have great potential in biomedical applications, with collective behaviors among tiny active agents benefiting clinical therapeutic and diagnostic methods. Recent developments in smart materials, remote actuation modalities, and automatic control strategies have improved the motion dexterity, environmental adaptability, and functionality versatility of micronanoswarms. Future success of these tools is expected to have a significant impact on clinical treatment.
Review
Biochemistry & Molecular Biology
Geun-Woo Jin, N. Sanoj Rejinold, Jin-Ho Choy
Summary: Polyphosphazenes (PPZs), with their structural flexibility and biodegradability, have attracted great interest as synthetic polymers in the field of biomedical science. The introduction of various functional groups has enabled the development of multi-functionalized PPZs, which have shown potential as biomaterials in the form of nanoparticles (NPs) and hydrogels for various applications such as drug delivery, bioimaging, phototherapy, bone regeneration, and dental liners.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mina Zare, Ashkan Bigham, Mohamad Zare, Hongrong Luo, Erfan Rezvani Ghomi, Seeram Ramakrishna
Summary: Poly(2-hydroxyethyl methacrylate) (pHEMA) is a biomaterial with excellent biocompatibility and cytocompatibility, making it suitable for various biomedical applications such as bone tissue regeneration, wound healing, cancer therapy, and ophthalmic applications. Antimicrobial strategies can be utilized to protect against infections at the site where biomedical devices are used. With continuous research and advancement in science and technology, the outlook of pHEMA is promising for future biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Tingting Hu, Zi Gu, Gareth R. Williams, Margarita Strimaite, Jiajia Zha, Zhan Zhou, Xingcai Zhang, Chaoliang Tan, Ruizheng Liang
Summary: In this review, the applications of layered double hydroxides (LDHs) in the field of biomedicine are comprehensively summarized. The preparation and surface modification methods of LDH-based nanomaterials are discussed, and the potential of LDHs in drug delivery, bioimaging, and cancer therapy are described. The remaining challenges and future prospects in this rapidly emerging field are also discussed.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Engineering, Environmental
Yiru Gao, Wenxin Zhang, Linyu Li, Zejun Wang, Yang Shu, Jianhua Wang
Summary: Ionic liquid-based gels have shown unprecedented roles in various fields and hold great promise in biomedical applications. Combining programmable gel assembly with the properties of ionic liquids enables the development of multifunctional ionic liquid gel-based materials.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Chemistry, Multidisciplinary
Jiajie Chen, Yufang Zhu, Stefan Kaskel
Summary: Metal-organic frameworks (MOFs) have received increasing attention in recent years, and the introduction of porphyrin molecules into MOFs has allowed for overcoming the limitations of porphyrins in biomedical applications. Porphyrin-based MOFs have made significant achievements and progress in areas such as tumor therapy and biosensing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Nasser Nikfarjam, Matineh Ghomi, Tarun Agarwal, Mahnaz Hassanpour, Esmaeel Sharifi, Danial Khorsandi, Moonis Ali Khan, Filippo Rossi, Arianna Rossetti, Ehsan Nazarzadeh Zare, Navid Rabiee, Davoud Afshar, Massoud Vosough, Tapas Kumar Maiti, Virgilio Mattoli, Eric Lichtfouse, Franklin R. Tay, Pooyan Makvandi
Summary: This article discusses the potential of ionic liquids as alternatives to antibiotics, exploring their antimicrobial mechanisms and factors influencing their antimicrobial activity, as well as their potential applications in the biomedical field.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Physical
Yuan Luo, Ming Lun Tseng, Sunil Vyas, Hsin Yu Kuo, Cheng Hung Chu, Mu Ku Chen, Hsiang-Chieh Lee, Wen-Pin Chen, Vin-Cent Su, Xu Shi, Hiroaki Misawa, Din Ping Tsai, Pan-Chyr Yang
Summary: This study demonstrates the application of an abrupt autofocusing beam generated by a nanophotonic metasurface in the field of biomedical research. By selectively delivering optical energy to specific locations, including mouse cardiac samples and ex vivo swine skin tissue, this technology shows great potential for miniature laser surgery instruments.
Article
Biochemistry & Molecular Biology
Catia Vieira Rocha, Victor Goncalves, Milene Costa da Silva, Manuel Banobre-Lopez, Juan Gallo
Summary: This review focuses on the combination of PLGA with different inorganic nanomaterials to overcome the limitations of the polymer and expand its applications in the field of nanomedicine. The physicochemical properties of these nanocomposites and various synthesis methods are discussed, along with recent progress in their design and biomedical applications, providing a framework for future research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
G. Acik, C. Altinkok, B. Acik
Summary: In this study, chlorinated polypropylene-chitosan composite films were successfully prepared by taking advantage of the polarity enhancing chlorine functionality of chlorinated polypropylene. The incorporation of chitosan increased the biodegradability and antibacterial activity of the films. Therefore, PP-Css showed great potential for bioengineering applications.
Article
Polymer Science
Irene Buj-Corral, Hector Sanz-Fraile, Anna Ulldemolins, Aitor Tejo-Otero, Alejandro Dominguez-Fernandez, Isaac Almendros, Jorge Otero
Summary: Three-dimensional printing is revolutionizing scaffold development. This study explores the use of metal-polymer composites as 3D printed scaffolds. The results show that steel-filled PLA polymers are biocompatible and can serve as valid scaffolds for bone tissue engineering.
Review
Chemistry, Multidisciplinary
Daniela Maria Correia, Liliana Correia Fernandes, Margarida Macedo Fernandes, Bruno Hermenegildo, Rafaela Marques Meira, Clarisse Ribeiro, Sylvie Ribeiro, Javier Reguera, Senentxu Lanceros-Mendez
Summary: Ionic liquids (ILs) have been extensively explored and applied in various fields, especially in biomedicine. They have unique properties that allow for the development of materials with specific functionalities, including improved dissolution and processability, when combined with natural and synthetic polymers. This review focuses on the recent advances of ILs in developing biomaterials for biomedical applications such as drug delivery, cancer therapy, tissue engineering, antimicrobial agents, and biosensing.
Article
Materials Science, Biomaterials
D. S. Abdullah Al Maruf, Krishnan Parthasarathi, Kai Cheng, Payal Mukherjee, David R. McKenzie, Jeremy M. Crook, Gordon G. Wallace, Jonathan R. Clark
Summary: This review focuses on the recent progresses in modulating the physiochemical properties and applications of biomaterials in bone tissue engineering (BTE) for mandibular segmental defect repair. BTE is an important strategy for reconstructing critical-sized bone defects and improving patients' quality of life.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Engineering, Chemical
Andrew Nattestad, Klaudia Wagner, Gordon G. Wallace
Summary: There is currently a lot of interest in converting carbon dioxide to more useful chemicals. However, the transition from laboratory-scale to practical-scale electrochemical reduction of carbon dioxide remains relatively unexplored. This study examines the challenges and proposes strategies such as increasing electrode area and stacking electrode pairs to achieve scale-up.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2023)
Article
Engineering, Environmental
Kezhong Wang, Yunfeng Chao, Zhiqi Chen, Sepidar Sayyar, Caiyun Wang, Gordon Wallace
Summary: A facile coaxial wet-spinning method was used to continuously produce hollow graphene fibers with high conductivity and flexibility. The resulting fibers exhibited outstanding electrochemical and mechanical properties, making them promising candidates for use in wearable supercapacitors and electronics.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Polymer Science
Abdul Moqeet Hai, Zhilian Yue, Stephen Beirne, Gordon Wallace
Summary: Electrowriting combines 3D printing and electrospinning to produce complex structures with submicron resolutions. This study demonstrates the compatibility of water-based silk fibroin ink with electrowriting and explores the optimization of ink composition and process parameters. The electrowriting of hydrophilic silk fibroin has the potential to create material structures with biological properties similar to natural systems.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Physical
Kyuman Kim, Pawel Wagner, Klaudia Wagner, Attila J. J. Mozer
Summary: Electrochemical CO2 reduction in non-aqueous media with Cu complex catalysts can selectively produce carbon monoxide or formic acid. This study demonstrates the highly selective electrochemical CO2 reduction to methane using a specific Cu2+ complex catalyst in dimethylformamide. The choice of electrolyte significantly affects the type and efficiency of the products, with alkali metal cations leading to the deposition of insulating carbonates and lower methane production. The morphology of the catalyst also plays a role in the variation of methane production efficiency.
Correction
Chemistry, Physical
Jonathan Hopkins, Kristina Fidanovski, Lorenzo Travaglini, Daniel Ta, James Hook, Pawel Wagner, Klaudia Wagner, Antonio Lauto, Claudio Cazorla, David Officer, Damia Mawad
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Physical
Samuel J. Harris, C. John McAdam, Pawel Wagner, Joseph I. Mapley, Keith C. Gordon
Summary: The vibrational and electronic properties of six systematicallyaltered donor-acceptor dyes were investigated using DFT, spectroscopy, and electrochemical techniques. The results showed that the geometry of the dyes was planar with extended pi-systems. The absorption and emission spectra demonstrated pi-pi* and charge transfer transitions, respectively, and the emission behavior was influenced by the acceptor units.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Chemistry, Physical
Munavvar Fairoos Mele Kavungathodi, Pawel Wagner, Shogo Mori, Attila J. Mozer
Summary: In this study, it was found that high-oxidation-potential Cu1+ complexes exhibit fast electron transfer towards oxidized dyes but slow dye regeneration. The presence of Cu2+ complexes accelerates the recombination reaction between electrons and the oxidized dye. The previously unknown acceleration of kinetics could impact the design and evaluation of new redox mediators at a low driving force.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Review
Chemistry, Physical
Ruibo Zhong, Sepehr Talebian, Barbara B. Mendes, Gordon Wallace, Robert Langer, Joao Conde, Jinjun Shi
Summary: RNA-based therapeutics hold great promise in disease intervention, and hydrogels are attracting attention for controlled release of these therapeutics. Hydrogels offer advantages such as biodegradability, tunable physiochemical properties, and precise spatiotemporal control over RNA release.
Article
Nanoscience & Nanotechnology
Gerardo Montoya, Klaudia Wagner, Gregory Ryder, Aida Shoushtari Zadeh Naseri, Shaikh Nayeem Faisal, Vitor Sencadas, Marc In Het Panhuis, Geoffrey M. Spinks, Gordon G. Wallace, Gursel Alici, David L. Officer
Summary: This paper reports on the mechanical and electrochemical properties of a polydimethyl-siloxane (PDMS) composite with edge-functionalized graphene (EFG) and demonstrates its potential for use in neural implants by fabricating a novel neural cuff electrode. The composite showed desirable stretchability, mechanical stability, and increased electrochemical properties after reduction, making it a promising material for interfacing with soft tissue.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Cell & Tissue Engineering
Tajanka Mladenovska, Peter F. Choong, Gordon G. Wallace, Cathal D. O'Connell
Summary: New developments in additive manufacturing and regenerative medicine have the potential to disrupt traditional therapy development and medical device manufacture. Regulators face challenges in adapting traditional regulatory frameworks for bespoke solutions and incorporating living cells in 3D bioprinting. This perspective discusses the regulatory challenges of 3D bioprinting in comparison to existing cell therapies and custom-made medical devices, including classification, risk, standardization, and quality control.
REGENERATIVE MEDICINE
(2023)
Review
Engineering, Biomedical
Kristina Fidanovski, Modi Gu, Lorenzo Travaglini, Antonio Lauto, Damia Mawad
Summary: Conjugated polymers play a crucial role in flexible bioelectronics due to their organic nature that allows for modification and tuning. The use of dopants in organic semiconductors can result in deterioration of electronic properties, leading to the development of self-doped and self-acid-doped polymers. While the terms are often used interchangeably, their doping mechanisms differ, with self-doped polymers requiring an external dopant for charge transfer and self-acid-doped polymers being inherently doped. Drawing a distinction between the two categories is important to understand their unique properties and potential applications. Examples of self-acid-doping in bioelectronics highlight the stability of these polymers under physiological conditions. However, a lack of clarity in terminology in the literature limits the understanding and development of these important bioelectronic components.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Jonathan Hopkins, Daniel Ta, Antonio Lauto, Carly Baker, John Daniels, Pawel Wagner, Klaudia K. Wagner, Nigel Kirby, Claudio Cazorla, David L. Officer, Damia Mawad
Summary: The film morphology of conjugated polymers has a significant impact on their electrochemical performance. The balance between crystalline and amorphous domains is crucial for achieving optimal ionic-electronic conductance. This study compared the morphological and electrochemical properties of poly(ethylenedioxythiophene) polymers functionalized with phosphonate groups separated by methylene and butylene alkyl spacers. Extending the spacer from methylene to butylene increased structural ordering in the solid state, but resulted in short-range ordered domains separated by amorphous regions, negatively affecting intermolecular charge transport and the uptake of hydrated counterions.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Engineering, Biomedical
Reem M. Almasri, Francois Ladouceur, Damia Mawad, Dorna Esrafilzadeh, Josiah Firth, Torsten Lehmann, Laura A. Poole-Warren, Nigel H. Lovell, Amr Al Abed
Summary: Optrode arrays utilize light to modulate biological tissues and transduce bioelectrical signals into the optical domain. This review provides an overview of devices and material systems that use light for electrophysiology recording and stimulation.
APL BIOENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Qilong Wu, Fangfang Zhu, Gordon Wallace, Xiangdong Yao, Jun Chen
Summary: This article introduces the severity of nitrogen pollution and calls for joint action for sustainable nitrogen use. Electrocatalytic NW reduction is presented as a potentially greener alternative for recycling NW and producing high-value chemicals. However, there are challenges in integrating this technology into upstream and downstream industrial chains. The article discusses future directions for optimizing production processes and providing nitrogenous raw materials.
CHEMICAL SOCIETY REVIEWS
(2023)
