期刊
JOURNAL OF MATERIALS CHEMISTRY
卷 21, 期 9, 页码 2974-2981出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0jm02660c
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资金
- Andalusian Regional Ministry of Health the Andalusian Initiative for Advanced Therapies-Fundacion Progreso y Salud
In this paper we describe the synthesis and the optimisation of a new family of fluorescent core-shell nanoparticle using protein-stabilised gold nanoclusters. Fluorescent gold nanoclusters (<2 nm) entrapped in bovine serum albumin (BSA) protein were loaded in a 100 nm-silica nanoparticle with an optimal concentration of 3% (w/w). These nanoparticles kept the fluorescence properties of the metal clusters with a high Stokes shift and an emission in the near infrared region (lambda = 670 nm). They were fully characterized and showed a high monodispersity and stability over more than 5 months. Steady-state fluorescence and lifetime measurements indicate the role of silica as a protective host to improve the photostability and the chemical stability of the fluorescent compound. This new label was taken up in tumor lung cells and tracked by a confocal microscope to show the great potential of this biolabel for sensing and imaging.
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