Article
Clinical Neurology
Jun Li, Ben-Fan Zhu, Zhu-Qin Gu, Hui Zhang, Shan-Shan Mei, Shao-Zhen Ji, Shu-Ying Liu, Chao Han, Huai-Zhen Chen, Piu Chan
Summary: Musculoskeletal pain is common in PD patients, with lower limbs and back being the typical sites. Female sex and Levodopa dosage are associated with an increased risk of musculoskeletal pain, while pain duration, motor symptoms, and depression significantly impact quality of life.
FRONTIERS IN NEUROLOGY
(2022)
Article
Rehabilitation
Conran Joseph, Hanna Johansson, Breiffni Leavy, Erika Franzen
Summary: This study demonstrates the convergent and divergent validity of the Swedish translated version of the King's Parkinson's disease Pain Scale. The prevalence of pain in persons with Parkinson's disease is 57%, with musculoskeletal pain being the most common, followed by chronic and radicular pain.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Clinical Neurology
Liang Gao, Weiling Huang, Laisheng Cai, Yufen Peng
Summary: The Chinese translation of King's Parkinson's Disease Pain Scale (KPPS) is a reliable tool to assess pain characteristics and severity in patients with Parkinson's disease (PD), and it has the ability to distinguish different levels of pain severity.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Clinical Neurology
J. Naisby, R. A. Lawson, B. Galna, L. Alcock, D. J. Burn, L. Rochester, A. J. Yarnall
Summary: Pain is a common non-motor symptom in Parkinson's disease, with unexplained pain being prevalent even in early stages. The frequency and type of pain fluctuates as symptoms progress, highlighting the importance of asking PD patients about their pain at clinical consultations and providing support in describing it.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Parisa Alizadeh, Cinthia Terroba-Chambi, Beatrice Achen, Veronica Bruno
Summary: This comprehensive review analyzes the association between pain and monogenic forms of Parkinson's disease (PD). The findings suggest that individuals with different pathogenic variants may experience different types of pain. However, there is insufficient evidence for pain associated with certain pathogenic variants.
FRONTIERS IN NEUROLOGY
(2023)
Review
Neurosciences
Jose Luis Cortes-Altamirano, Samuel Reyes-Long, Cindy Bandala, Abril Morraz-Varela, Herlinda Bonilla-Jaime, Alfonso Alfaro-Rodriguez
Summary: Pain is often disregarded in Parkinson's disease, leading to inadequate treatment. Neuropathic pain is common in PD and is associated with changes in neurotransmitters like dopamine.
Article
Clinical Neurology
Liang Gao, Weiling Huang, Laisheng Cai, Huihua Li
Summary: This study found that sleep disturbances are associated with pain in Parkinson's disease patients and may have a greater impact on certain subtypes of pain.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Kanako Kurihara, Shinsuke Fujioka, Takayasu Mishima, Yoshio Tsuboi
Summary: This study evaluated pain in patients with Parkinson's disease using PainVision(R) and found that the pain intensity assessment with PainVision(R) did not correlate with conventional subjective pain assessments. The current perception threshold was related to the duration and severity of the disease and may be involved in peripheral neuropathy associated with Parkinson's disease.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Kaoru Kinugawa, Tomoo Mano, Kazuma Sugie
Summary: This study found that aberrant synchronization of inter-temporal regions is involved in pain in Parkinson's disease, which contributes to a better understanding of the mechanisms underlying pain in PD.
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Health Care Sciences & Services
Stefania Diaconu, Laura Irincu, Larisa Ungureanu, Bogdan Ciopleias, Diana Tint, Cristian Falup-Pecurariu
Summary: In this cross-sectional study of 131 Parkinson's disease patients, 26.71% met the diagnostic criteria for restless legs syndrome (RLS). RLS was associated with poorer sleep quality and significant correlations were found between RLS and certain types of pain (especially nocturnal pain), physical fatigue, and probable sleep-disordered breathing.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Immunology
Katiane Roversi, Natalia Callai-Silva, Karine Roversi, May Griffith, Christos Boutopoulos, Rui Daniel Prediger, Sebastien Talbot
Summary: Parkinson's disease is the second most common neurodegenerative disorder, with both motor and non-motor symptoms. Dysbiosis in the gut microbiota is linked to the severity of PD symptoms and somatosensory hypersensitivity, highlighting the importance of gut immunity in PD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Diego Santos Garcia, Rosa Yanez Bana, Carmen Labandeira Guerra, Maria Iciar Cimas Hernando, Iria Cabo Lopez, Jose Manuel Paz Gonzalez, Maria Gema Alonso Losada, Maria Jose Gonzalez Palmas, Carlos Cores Bartolome, Cristina Martinez Miro
Summary: The SAFINONMOTOR study analyzed the effectiveness of safinamide on pain in Parkinson's disease patients, showing a significant reduction in pain levels within 6 months. Improvement was particularly observed in musculoskeletal, fluctuation-related, nocturnal, discoloration and/or edema/swelling, and radicular pain. Adverse events were reported in 22% of patients, but they were not related to safinamide.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Liang Gao, Yong Yang, Laisheng Cai, Yuanping Xiong
Summary: This study determined the influence of gender on different pain subtypes in patients with PD, finding that female patients had stronger associations with certain PD-related pain subtypes.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2022)
Article
Clinical Neurology
Kui Chen, Meng-Ruo Guo, Yue Zhang, Gang Li, Yi Liu, Bei Zhang
Summary: The study revealed an association between MMP16 rs60298754 and symptoms of Parkinson's disease in southern Chinese patients, including apathy, pain, nocturia, and sensitivity to light.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Jin-ru Zhang, Yu-lan Cao, Kai Li, Fen Wang, Ya-li Wang, Jia-jing Wu, Shao-fang Pei, Jing Chen, Cheng-jie Mao, Chun-feng Liu
Summary: The study found that in PD patients, those with thin baseline RNFL thickness performed worse in global cognitive tests, delayed memory, and executive functions, with more significant cognitive deterioration during follow-up. Lower baseline average RNFL thickness was associated with greater annualized decline in Mini-Mental State Examination and Montreal Cognitive Assessment.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Geriatrics & Gerontology
Mei-Hong Lu, Wen-Li Ji, Hong Chen, Yan-Yun Sun, Xiu-Yun Zhao, Fen Wang, Yi Shi, Yan-Ning Hu, Bo-Xiang Liu, Jing-wen Wu, De-En Xu, Jia-Wei Zheng, Chun-Feng Liu, Quan-Hong Ma
Summary: The study demonstrated that intranasal delivery of human neural stem cells showed positive effects in Alzheimer's disease by improving pathological damages and rescuing cognitive function in transgenic mice.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chao Ren, Ling-Xi Li, An-Qi Dong, Yu-Ting Zhang, Hua Hu, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu
Summary: The relationship between depression and Parkinson's disease is still not fully understood. This study suggests that depression may worsen dyskinesia and death of dopaminergic neurons in a PD model by promoting microglial activation and neuroinflammation mediated by P2X7R. Inhibition of P2X7R could be a new control strategy for PD associated with depression.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Cell Biology
Chao Gu, Fen Wang, Yu-Ting Zhang, Shi-Zhuang Wei, Jun-Yi Liu, Hong-Yang Sun, Guang-Hui Wang, Chun-Feng Liu
Summary: Studies indicate that MT1 activation inhibits LPS-induced microglial activation through regulating its metabolic reprogramming, providing insight into the anti-inflammatory role of microglial MT1.
Review
Cell & Tissue Engineering
Yu-Ting Zhang, Kai-Jie He, Jin-Bao Zhang, Quan-Hong Ma, Fen Wang, Chun-Feng Liu
Summary: This review discusses the possible brain-entry routes of stem cells administered intranasally to bypass the blood-brain barrier, as well as the advantages and disadvantages of this treatment method in central nervous system diseases, providing a reference for the application of intranasal stem cell therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Geriatrics & Gerontology
Chao Ren, Fen Wang, Kai-Jie He, Yu-Ting Zhang, Ling-Xi Li, Jin-Bao Zhang, Jing Chen, Cheng-Jie Mao, Chun-Feng Liu
Summary: Early-life stress can have long-term effects on human health, including the development of neurodegenerative diseases like Parkinson's disease. In this study, the researchers used a maternal separation model to explore the contribution of early-life stress to Parkinson's disease. They discovered behavioral, histochemical, neuromorphological, and transcriptional changes in rats that were separated from their mothers, providing new insights into the pathogenesis and potential therapies for Parkinson's disease related to depression.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Letter
Medicine, General & Internal
Yun Shen, Siyi Gong, Yulu Liu, Jie Li, Kangping Xiong, Chengjie Mao, Yali Wang, Dan Li, Fen Wang, Hua Hu, Chunfeng Liu
CHINESE MEDICAL JOURNAL
(2022)
Article
Neurosciences
Chao Ren, Kai-Jie He, Hua Hu, Jin-Bao Zhang, Li-Guo Dong, Dan Li, Jing Chen, Cheng-Jie Mao, Fen Wang, Chun-Feng Liu
Summary: This study found that knocking down astrocytic GLT-1 could lead to PD-like changes, including impaired motor function, abnormal gait, and depression-like features. Additionally, the dopaminergic system was impaired and the count of tyrosine hydroxylase (TH) positive neurons was reduced in astrocytic GLT-1 knockdown rats. Blocking glutamate excitotoxicity may provide a new strategy for the prevention and treatment of PD.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Chemistry, Multidisciplinary
An-Qi Dong, Ya-Ping Yang, Shu-Min Jiang, Xiao-Yu Yao, Di Qi, Cheng-Jie Mao, Xiao-Yu Cheng, Fen Wang, Li-Fang Hu, Chun-Feng Liu
Summary: This study demonstrates the anti-neuroinflammatory activity of PPX through enhancing autophagy activity in astrocytes, which provides a new mechanism for the beneficial effect of PPX in Parkinson's disease therapy.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Ying Chen, Qing Yin, Xiao-Yu Cheng, Jin-Ru Zhang, Hong Jin, Kai Li, Cheng-Jie Mao, Fen Wang, Hong-Zhe Bei, Chun-Feng Liu
Summary: Induced pluripotent stem cells (iPSCs) can successfully mimic age-related diseases, such as Parkinson's disease (PD). In this study, we differentiated dopaminergic (DA) neurons from iPSCs of PD patients with the G2019S LRRK2 mutation and found morphological changes compared to control group. Furthermore, we observed that these mutated DA neurons were more vulnerable to damage, with higher rates of apoptosis and inflammatory response.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Cheng-Jie Li, Li-Ge Zhang, Lu-Bing Liu, Meng-Qi An, Li-Guo Dong, Han-Ying Gu, Yong-Ping Dai, Fen Wang, Cheng-Jie Mao, Chun-Feng Liu
Summary: Pain in Parkinson's disease (PD) is a major factor affecting the life quality of PD patients. Traditional therapeutic drugs lacking efficacy on PD-related pain suggest the involvement of a mechanism outside the dopamine system. Previous studies have shown that decreased serotonin levels in the spinal dorsal horn (SDH) are associated with increased pain sensitivity in a 6-OHDA-induced PD model. In this study, we found that inhibition of spinal 5-HT3 receptors and reduction of SDH neuronal excitability can alleviate hyperalgesia in PD rats. These findings provide a novel mechanism and potential therapeutic strategy for pain management in PD patients.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Cell Biology
Qian-Kun Lv, Kang-Xin Tao, Xiao-Bo Wang, Xiao-Yu Yao, Meng-Zhu Pang, Jun-Yi Liu, Fen Wang, Chun-Feng Liu
Summary: Parkinson's disease is a common neurodegenerative disease characterized by the accumulation of alpha-synuclein in microglia, leading to neuroinflammation. The autophagy and phagocytosis functions of microglia are related to the clearance of alpha-synuclein and the inhibition of neuroinflammation. This review discusses the interaction between microglia and alpha-synuclein in Parkinson's disease pathogenesis, and the possible mechanisms of microglial autophagy and phagocytosis in the clearance of alpha-synuclein and inhibition of neuroinflammation.
INFLAMMATION RESEARCH
(2023)
Article
Neurosciences
Jun-Yi Liu, Jian Xue, Fen Wang, Ya-Li Wang, Wan-Li Dong
Summary: Circadian dysfunction is a common non-motor symptom in Parkinson's disease. The potential influence of SNCA on circadian disruption remains unclear. This study showed that overexpression of SNCA induced biorhythm disruption and downregulated BMAL1 expression through decreasing stability of BMAL1 mRNA via miR-155.
NEUROTOXICITY RESEARCH
(2023)
Article
Oncology
Zhong-Ming Ying, Qian-Kun Lv, Xiao-Yu Yao, An-Qi Dong, Ya-Ping Yang, Yu-Lan Cao, Fen Wang, Ai-Ping Gong, Chun-Feng Liu
Summary: This study demonstrates that BAG3 promotes autophagy and suppresses the formation of NLRP3 inflammasome in Parkinson's disease.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Yi-Lun Ge, Si-Yi Gong, Pu-Zhi Wang, Jia-Hui Yan, Wen Li, Jin-Ru Zhang, Hong Jin, Sheng Zhuang, Lei Hu, Chang-Wei Ding, Ya-Ping Yang, Fen Wang, Dan Li, Jing Chen, Cheng-Jie Mao, Ying-Chun Zhang, Kai Li, Chun-Feng Liu
Summary: This study aimed to assess the association between cerebrovascular function and cognitive performance in patients with Parkinson's disease (PD). The results showed that cerebrovascular function was significantly associated with cognitive performance, especially in the memory task. A model combining clinical and hemodynamic variables was effective in identifying cognitive impairment in PD patients, which could be a useful tool for early screening of cognitive decline. Further studies with larger sample sizes in different populations are needed.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)