Article
Psychology, Clinical
Blair N. Honsey, Lauren O. Erickson, Kathryn A. Wyman-Chick
Summary: In early-stage Parkinson's disease patients, depression does not significantly affect neuropsychological test performance. The depressed group was younger with lower education, but performed worse on the working memory task. The study suggests that in this population, depression does not have a significant impact on cognitive abilities.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Article
Clinical Neurology
Ruwei Ou, Qianqian Wei, Yanbing Hou, Lingyu Zhang, Kuncheng Liu, Xiangwei Kong, Shuying Li, Lan Wang, Xianran Xu, Xiaojing Gu, Junyu Lin, Zheng Jiang, Jiao Liu, Wei Song, Bei Cao, Huifang Shang
Summary: Patients with early-onset Parkinson's disease (EOPD) have a higher prevalence of suicidal ideation (SI) and depression, with risk factors including depression, non-smoking, and lower education level.
JOURNAL OF NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Jessica Ann Peterson, Grant Chesbro, Rebecca Larson, Daniel Larson, Christopher D. Black
Summary: The study found that social distancing policies during the COVID-19 pandemic have negative effects on people's mental health, leading to worsening depression, anxiety, and mood state. While physical activity levels did not change over time, they were closely associated with mental health conditions.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Alicia Remartinez-Hamed, Maria Angeles Perez-Morente, Maria Adelaida Alvarez-Serrano, Encarnacion Martinez-Garcia, Alberto Gonzalez-Garcia, Inmaculada Garcia-Garcia, Adelina Martin-Salvador
Summary: Pregnancy and/or the puerperium increase the vulnerability of women to mental disorders, especially anxiety and depression, and this risk is further heightened during stressful contexts such as the COVID-19 pandemic. A study conducted in Melilla, a Spanish cross-border city with Morocco, found a high risk of postpartum depression (85.5%) and anxiety (63.8%), with severe anxiety affecting 40.6% of cases. Predictors of postpartum depression included a personal history of mood disorders and a COVID-19 diagnosis during pregnancy or postpartum. Factors predicting anxiety included mood antecedents, a COVID-19 diagnosis during pregnancy or postpartum, and being a multipara. Special attention should be given to women with a history of mood disorders and a positive COVID-19 diagnosis during pregnancy or postpartum, particularly multiparous women, due to their impact on postpartum mental health.
CURRENT PSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Catherine E. Munro, Rachel Buckley, Patrizia Vannini, Carla DeMuro, Reisa Sperling, Dorene M. Rentz, Keith Johnson, Jennifer R. Gatchel, Rebecca Amariglio
Summary: This study investigates the longitudinal trajectories of cognitive concerns reported by participants and their study partners, and explores the relationship between these concerns, AD biomarkers, and mood symptomatology. The results suggest that baseline mood significantly influences participant-rated concerns, while baseline amyloid and tau levels have a significant impact on study partner concerns. These findings highlight the importance of remote assessments of study partner-reported concerns in understanding the AD clinical spectrum.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Meiling Liu, Ben Chen, Xiaomei Zhong, Min Zhang, Qiang Wang, Huarong Zhou, Zhangying Wu, Le Hou, Qi Peng, Si Zhang, Minfeng Yang, Gaohong Lin, Yuping Ning
Summary: There is a difference in odor identification (OI) dysfunction between patients with late onset depression (LOD) and early onset depression (EOD), with LOD patients exhibiting worse OI. Additionally, OI dysfunction is not significantly correlated with cognitive function in LOD patients.
Article
Geriatrics & Gerontology
Monica Gagliardi, Radha Procopio, Mariagrazia Talarico, Andrea Quattrone, Gennarina Arabia, Maurizio Morelli, Marco D'Amelio, Donatella Malanga, Giuseppe Bonapace, Aldo Quattrone, Grazia Annesi
Summary: Recently, a novel pathogenic variant in Annexin A1 protein has been identified in an Iranian family with autosomal recessive Parkinsonism. This study aimed to identify rare ANXA1 variants in early-onset PD patients from South Italy. However, sequencing analysis revealed only 2 synonymous variants, suggesting that the recently published ANXA1 mutation is not a common cause of EOPD in Southern Italy.
NEUROBIOLOGY OF AGING
(2023)
Article
Clinical Neurology
Frank Iorfino, Ciro Marangoni, Lihong Cui, Daniel F. Hermens, Ian B. Hickie, Kathleen Ries Merikangas
Summary: The study found that anxiety-related temperamental traits show familial specificity, but these traits cannot fully explain the shared heritability between anxiety subtypes and mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Geriatrics & Gerontology
Chien-Tai Hong, Shennie Tan, Tsai-Wei Huang
Summary: Psychotherapeutic interventions, especially cognitive-behavioral therapy, are effective in managing anxiety and depression in patients with Parkinson's disease, significantly reducing symptoms. CBT has a significant alleviating effect on anxiety and depression, while non-CBT interventions are also effective in reducing depressive symptoms.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Yosef Sokol, Chayim Rosensweig, Chynna Levin, Mairav Linzer
Summary: The study found that anxiety symptoms have a unique association with temporal self-appraisal, with individuals with anxiety showing a similar positive trend in self-view to euthymic individuals, but with overall lower self-evaluation at each temporal point. Depressed individuals had a stable past-to-present self-view and an improving present-to-future self-view.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Janelle S. Peifer, Erin Bradley, Gita Taasoobshirazi
Summary: The necessity of hybrid and more accessible options for perinatal mood and anxiety disorders (PMADs) has become more urgent due to the COVID-19 pandemic. This study found that a hybrid intervention combining in-person and teletherapy had positive effects on early outcomes for new parents, including improvements in mental health symptoms and potential improvements in postpartum anxiety and self-efficacy.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Joseph Degutis, Courtney Aul, Olivier J. Barthelemy, Breanna L. Davis, Shaikhah Alshuaib, Anna Marin, Shraddha B. Kinger, Terry D. Ellis, Alice Cronin-Golomb
Summary: This study found that individuals with LPD had poorer sustained attention performance compared to RPD patients before training, and were more likely to show improvement in clinical motor functioning after sustained attention training.
Article
Medicine, General & Internal
Na Wu, Xiangmei Kong, Xinghuai Sun
Summary: Anxiety and depression are common in Chinese patients with glaucoma. The self-reported VR-QoL is beneficial in assessing the psychological status of patients, while objective visual function indices provide little indication of it.
Article
Clinical Neurology
D. L. Wescott, M. L. Taylor, A. M. Klevens, P. L. Franzen, K. A. Roecklein
Summary: The study investigates the impact of nightly changes in sleep duration, timing, and quality on morning affect, with a focus on the moderating role of depression severity. The findings suggest that sleeping longer and later than usual are associated with better morning mood. Additionally, participants with higher depression severity experience worse affect upon waking after sleeping less than their usual. These results provide insight into the relationship between sleep disturbances, depression, and morning affect.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Medicine, General & Internal
Yuanyuan Wang, Jens H. Bos, Catharina C. M. Schuiling-Veninga, H. Marike Boezen, Job F. M. van Boven, Bob Wilffert, Eelko Hak
Summary: The study found that there was a lower incidence of NPAEs among general population using varenicline compared to nicotine replacement therapy, while there was no significant difference in NPAEs incidence between COPD patients using varenicline and NRT.
Article
Clinical Neurology
Stefano Tozza, Dario Bruzzese, Daniele Severi, Emanuele Spina, Rosa Iodice, Lucia Ruggiero, Raffaele Dubbioso, Aniello Iovino, Francesco Aruta, Maria Nolano, Lucio Santoro, Fiore Manganelli
Summary: The perception of disturbances that mostly impact on CMT1A patients' daily life changes over the lifetime and with degree of disability, with weakness in lower limbs being the most important disturbance and weakness in upper limbs having the lowest impact.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Emanuele Spina, Pietro Emiliano Doneddu, Giuseppe Liberatore, Dario Cocito, Raffaella Fazio, Chiara Briani, Massimiliano Filosto, Luana Benedetti, Giovanni Antonini, Giuseppe Cosentino, Stefano Jann, Anna Mazzeo, Andrea Cortese, Girolama Alessandra Marfia, Angelo Maurizio Clerici, Gabriele Siciliano, Marinella Carpo, Marco Luigetti, Giuseppe Lauria, Tiziana Rosso, Guido Cavaletti, Erdita Peci, Stefano Tronci, Marta Ruiz, Stefano Cotti Piccinelli, Angelo Schenone, Luca Leonardi, Luca Gentile, Laura Piccolo, Giorgia Mataluni, Lucio Santoro, Eduardo Nobile-Orazio, Fiore Manganelli
Summary: Electrophysiological diagnosis of CIDP can be challenging, but analyzing data from a large number of patients can provide practical advice to improve diagnostic accuracy.
NEUROLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Annamaria Vallelunga, Tommaso Iannitti, Sabrina Capece, Gerardina Somma, Maria Claudia Russillo, Alexandra Foubert-Samier, Brice Laurens, Igor Sibon, Wassilios G. Meissner, Paolo Barone, Maria Teresa Pellecchia
Summary: This study investigated miR-96-5p and miR-339-5p as novel biomarkers for the differential diagnosis between PD and MSA. MiR-96-5p was significantly increased in MSA patients compared to PD and HC, while miR-339-5p showed a significant increase in MSA patients compared to both PD and HC groups.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Sofia Cuoco, Arianna Cappiello, Filomena Abate, Maria Francesca Tepedino, Roberto Erro, Giampiero Volpe, Maria Teresa Pellecchia, Paolo Barone, Marina Picillo
Summary: This study validated the psychometric properties of BDI-II in PSP patients, established a cut-off for identifying depression, and found correlations with quality of life. The results indicate that BDI-II is a reliable and valid tool for assessing depression symptoms in PSP.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Sofia Cuoco, Immacolata Carotenuto, Arianna Cappiello, Sara Scannapieco, Maria Claudia Russillo, Valentina Andreozzi, Lorenzo Forino, Marianna Amboni, Marina Picillo, Roberto Erro, Paolo Barone, Maria Teresa Pellecchia
Summary: The study revealed that patients with OH had better performance on certain tasks initially, but experienced cognitive decline over time compared to patients without OH. A significant predictive factor for global cognitive status worsening at follow-up was the presence of OH, along with age, education, and MOCA score.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Marina Picillo, Maria Francesca Tepedino, Maria Claudia Russillo, Filomena Abate, Marta Savastano, Antonio De Simone, Roberto Erro, Maria Teresa Pellecchia, Paolo Barone
Summary: Progressive supranuclear palsy is associated with reduced total daily energy expenditure and physical activity, as well as lower lean muscle mass compared with Parkinson's disease. The Harris-Benedict equation has limited accuracy in predicting rest energy expenditure in PSP patients. Disease severity is correlated with lower rest energy expenditure, lean muscle mass, and muscle mass in this population.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Marina Picillo, Maria Francesca Tepedino, Filomena Abate, Sara Ponticorvo, Roberto Erro, Sofia Cuoco, Nevra Oksuz, Gianfranco Di Salle, Francesco Di Salle, Fabrizio Esposito, Maria Teresa Pellecchia, Renzo Manara, Paolo Barone
Summary: This study evaluated the asymmetry in motor and higher cortical features in PSP-RS patients and found that these features were commonly asymmetric in PSP-RS. There was also a greater degree of asymmetry in the hemispheres compared to healthy controls. These findings contribute to a better understanding of the characteristics of PSP-RS.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Sofia Cuoco, Immacolata Carotenuto, Arianna Cappiello, Rossella Bisogno, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone, Roberto Erro
Summary: The study explores the psychometric properties of the Italian version of the RS-14 and the relationship between RS-14, mood, and quality of life. Results show good acceptability, reliability, and validity of the Italian RS-14, with a two-factor structure of 'Self-confidence' and 'Self-control'. The study highlights the impact of resilience on mental health, with lower resilience correlating with higher levels of anxiety and depression.
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Gregor K. Wenning, Iva Stankovic, Luca Vignatelli, Alessandra Fanciulli, Giovanna Calandra-Buonaura, Klaus Seppi, Jose-Alberto Palma, Wassilios G. Meissner, Florian Krismer, Daniela Berg, Pietro Cortelli, Roy Freeman, Glenda Halliday, Gunter Hoeglinger, Anthony Lang, Helen Ling, Irene Litvan, Phillip Low, Yasuo Miki, Jalesh Panicker, Maria Teresa Pellecchia, Niall Quinn, Ryuji Sakakibara, Maria Stamelou, Eduardo Tolosa, Shoji Tsuji, Tom Warner, Werner Poewe, Horacio Kaufmann
Summary: This study aims to develop novel diagnostic criteria for multiple system atrophy (MSA) using an evidence-based and consensus-based methodology to improve the diagnostic accuracy, particularly in early disease stages. The criteria were developed and optimized through systematic literature review, Delphi rounds, and a virtual Consensus Conference. Different clinical diagnostic categories were defined, and a new concept of possible prodromal MSA was introduced. Brain magnetic resonance imaging markers were required for the diagnosis of clinically established MSA.
MOVEMENT DISORDERS
(2022)
Article
Geriatrics & Gerontology
Sara Ponticorvo, Renzo Manara, Ettore Cassandro, Antonietta Canna, Alfonso Scarpa, Donato Troisi, Claudia Cassandro, Sofia Cuoco, Arianna Cappiello, Maria Teresa Pellecchia, Francesco Di Salle, Fabrizio Esposito
Summary: Age-related sensorineural hearing loss is closely associated with brain functional and structural changes, especially in the visual subnetwork. This study analyzed this correlation using a multimodal connectomic approach and found functional repurposing of visual cortical centers in the presence of hearing loss.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Marina Picillo, Giulio Salerno, Maria Francesca Tepedino, Filomena Abate, Sofia Cuoco, Marco Gioia, Alessia Coppola, Roberto Erro, Maria Teresa Pellecchia, Nicola Rosa, Paolo Barone, Maddalena De Bernardo
Summary: This study describes retinal layer thickness in patients with progressive supranuclear palsy (PSP) compared to healthy controls using spectral-domain optical coherence tomography (SD-OCT). The results show significant thinning of certain retinal layers in PSP patients compared to controls. The study also finds a significant correlation between retinal layer thickness and visuospatial abilities.
NEUROLOGICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Marianna Amboni, Carlo Ricciardi, Sofia Cuoco, Leandro Donisi, Antonio Volzone, Gianluca Ricciardelli, Maria Teresa Pellecchia, Gabriella Santangelo, Mario Cesarelli, Paolo Barone
Summary: This study aimed to compare gait patterns in PD-MCI subtypes to verify the association between specific gait features and particular MCI subtypes. The results showed that gait patterns were poorer in PD-MCI patients compared to those without MCI, and multiple-domain PD-MCI and amnestic PD-MCI were associated with worse gait patterns.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Food Science & Technology
Roberto Erro, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone
Summary: Cervical dystonia is a chronic disorder that significantly affects quality of life and requires long-term treatment. Although botulinum neurotoxin injections are highly effective, a substantial number of patients experience poor outcomes and discontinue treatment. Factors contributing to treatment failure include improper muscle targeting, dosing, injection technique, subjective inefficacy, and the development of neutralizing antibodies. This review identifies these factors and proposes potential solutions to improve treatment outcomes, such as using a new classification system for muscle targeting and employing kinematic or scintigraphic techniques for more accurate injections. A patient-centered model and increased awareness of the non-motor aspects of cervical dystonia, as well as the development of dedicated rehabilitation programs, may enhance the effectiveness of treatment.
Editorial Material
Clinical Neurology
Roberto Erro, Marina Picillo, Maria Teresa Pellecchia, Paolo Barone
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Geriatrics & Gerontology
Gabriella Santangelo, Simona Raimo, Roberto Erro, Marina Picillo, Marianna Amboni, Maria Teresa Pellecchia, Claudia Pivonello, Paolo Barone, Carmine Vitale
Summary: The study found that Vitamin D insufficiency is common in Parkinson's Disease patients, and low levels of 25(OH)D and lower education are predictors of PD-MCI development. Early diagnosis and management of Vitamin D insufficiency may help prevent cognitive decline in PD patients.
AGING & MENTAL HEALTH
(2021)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
