Review
Chemistry, Analytical
Veronica Termopoli, Maurizio Piergiovanni, Davide Ballabio, Viviana Consonni, Emmanuel Cruz Munoz, Fabio Gosetti
Summary: Membrane introduction mass spectrometry (MIMS) is a direct mass spectrometry technique that allows online monitoring and rapid quantification of trace levels of compounds in complex matrices without extensive sample preparation steps and chromatographic separation. It uses a thin, semi-permeable, and selective membrane to pre-concentrate analytes based on their physicochemical properties, and transfers them directly to the mass spectrometer using different acceptor phases.
Review
Chemistry, Analytical
Sebastien Allard, Frants R. Lauritsen
Summary: This review summarizes the progress in the use of MIMS for DBP analysis in water since 2010. It highlights advancements in instrumentation, quantification, and new applications in swimming pools, water treatment, mechanistic studies, and kinetic modelling. The review discusses the use of high resolution mass spectrometry for distinguishing between isobaric isomers, analysis of hydrophilic and less volatile DBPs using condensed phase MIMS, and quantification based on univariate and multivariate mathematical algorithms. MIMS has been proven to be a valuable tool for implementing water treatment strategies focusing on DBP mitigation.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Civil
Camille Vautier, Benjamin W. Abbott, Eliott Chatton, Thierry Labasque, Jean Marcais, Anniet M. Laverman
Summary: This study used a novel method (MIMS) to continuously characterize biological activity in a stream and compared it with traditional laboratory incubations. The results showed discrepancies between in situ measurements and laboratory incubations, suggesting a potential underestimation of nutrient removal rates in field conditions.
JOURNAL OF HYDROLOGY
(2023)
Article
Environmental Sciences
Wangshou Zhang, Hengpeng Li, Heng Cao
Summary: This study investigated the dynamics of nitrogen removal rate in a typical agricultural pond. It found significant differences in nitrogen removal rates between day and night, with higher rates at night due to fluctuation in dissolved oxygen levels. On a monthly scale, nitrogen removal rate was generally higher during warmer and rainier months, correlated with nitrogen levels in the pond.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biochemical Research Methods
Masato Taoka, Kota Kamei, Akiko Kashima, Yuko Nobe, Takahiro Takekiyo, Takamasa Uekita, Tohru Ichimura
Summary: Many ion channels and receptor proteins are potential targets for new drugs. This study presents a novel proteomic sample preparation platform that allows for the processing of sub-microgram level starting materials using an ionic liquid-based sample preparation strategy and an in-StageTip technique. This approach enables the rapid solubilization and analysis of integral membrane proteins from human samples, surpassing the performance of conventional methods.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Joseph Monaghan, Larissa C. Richards, Gregory W. Vandergrift, Lindsay J. Hounjet, Stanislav R. Stoyanov, Chris G. Gill, Erik T. Krogh
Summary: This study investigated the effects of crude oil spills on the hydrosphere, comparing the concentrations of petroleum-derived compounds in natural and constructed waters. Different types of oil were found to have varying impacts on water contamination. A novel mass spectrometry technique was used to concurrently analyze trace NAs and PAHs in water samples, providing a new method for rapid monitoring of contamination processes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Physics, Atomic, Molecular & Chemical
Sean Sebastian Hughes, Marcus M. K. Hughes, Rasmus Voersaa Jonsbo, Carsten Uhd Nielsen, Frants Roager Lauritsen, Bala Krishna Prabhala
Summary: Beer is a complex mixture of over 7700 compounds, with around 800 being volatile. The use of MIMS and KNIME software for analyzing and characterizing local Danish beers has shown promise in distinguishing beers from different micro-breweries, laying the groundwork for future analysis of beer volatome using MIMS.
EUROPEAN JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Chemistry, Analytical
E. Mavrakis, Z. Toprakcioglu, N. Lydakis-Simantiris, T. P. J. Knowles, S. A. Pergantis
Summary: As the use of microfluidic chips for biological samples handling increases, there is a growing demand to combine them with powerful analytical techniques such as ICP-MS. This study demonstrates the successful coupling of a chip-based supersonic microfluidic nebulizer to an ICP-MS through the use of a spray chamber with a laminar flow makeup gas. The system shows promising performance in single-particle and single-cell analysis.
ANALYTICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Salvia Sajid, Ishika Aryal, Suleman Farooq Chaudhri, Frants Roager Lauritsen, Mikkel Girke Jorgensen, Havard Jenssen, Bala Krishna Prabhala
Summary: Bacteria produce various volatile compounds throughout their lifecycle, and identifying these compounds is important for studying bacterial interactions. Common techniques such as GC and LC coupled to mass spectrometry can be challenging due to sample preparation. In this study, Membrane-inlet mass spectrometry (MIMS) was found to be a simple and effective method for detecting volatile compounds and differentiating between pathogenic and nonpathogenic bacterial strains.
Review
Chemistry, Analytical
Joao Raul Belinato, Vinicius Ricardo Acquaro, Luciana Teresa Dias Cappelini, Fabio Augusto
Summary: The interest in bioactive compounds from microorganisms has increased since the first discovery, with microorganisms being a key source of biomolecules with diverse applications. While conventional sample preparation techniques are still widely used, microextraction techniques show promise in overcoming limitations and promoting a deeper understanding of complex systems and the discovery of new molecules.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Essyllt Louarn, Antoinette Boreave, Guy Raffin, Christian George, Philippe Vernoux
Summary: Urban air pollution is caused by vehicle exhaust emissions, which have been regulated for over 30 years. Specific emission control systems are implemented in different motor types, such as the three-way catalytic converter (TWC) in gasoline vehicles. However, TWCs are only effective at certain temperatures and air-to-fuel ratios. This study analyzes the emission of unregulated VOCs from a mini-TWC under non-optimal conditions and identifies the formation of different VOCs, including carbonated, nitrile, and aromatic compounds.
Article
Biochemistry & Molecular Biology
Lingfeng Li, Tianyi Zhang, Wei Ge, Xingli He, Yunjing Zhang, Xiaozhi Wang, Peng Li
Summary: A novel sample introduction and ionization method for trace explosives detection is proposed and investigated, which has the advantages of soft ionization, a low detection limit, and is free of reagent and consumable gas.
Article
Chemistry, Analytical
Fenglin Shen, Yueting Xiong, Lei Zhang, Hengchao Li, Huanhuan Zhao, Xiaohui Liu, Pengyuan Yang
Summary: A new rapid and simple sample preparation method was developed for serum proteomic studies, allowing for efficient identification of multiple proteins in under 2 hours. This method has the potential to accelerate biomarker discovery and clinical application in serum protein research.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemical Research Methods
John B. Coulton, James L. Edwards
Summary: The sample preparation technique described in the study involves online filter-assisted electroporation-based cell lysis and chilled organic solvent extraction for rapid preparation of metabolomic samples from suspended cells. By using isotopically labeled internal standards and C-13-glucose labeling experiments, the method ensures enzymatic quenching and successful incorporation of C-13 into organic acid metabolites. Analysis by nano-reverse-phase liquid chromatography-mass spectrometry (nano-RP-LC-MS) demonstrates the effectiveness of the technique in studying metabolites such as itaconate.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Wei Hu, Frants Roager Lauritsen, Sebastien Allard
Summary: A Membrane Introduction Mass Spectrometry (MIMS) method was developed to differentiate and quantify chlorinated and brominated-amines in drinking water during chloramination. The method successfully monitored and quantified different compounds in water samples simulating a disinfection scenario.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)