期刊
JOURNAL OF MASS SPECTROMETRY
卷 49, 期 8, 页码 737-741出版社
WILEY-BLACKWELL
DOI: 10.1002/jms.3400
关键词
MALDI; mass spectrometry imaging; matrix; metabolites; small molecules; 1,5-diaminonaphthalene
资金
- US Department of Energy (DOE), Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences and Biosciences
- Iowa State University under DOE [DE-AC02-07CH11358]
1,5-diaminonaphthalene (DAN) has previously been reported as an effective matrix for matrix-assisted laser desorption ionization-mass spectrometry of phospholipids. In the current work, we investigate the use of DAN as a matrix for small metabolite analysis in negative ion mode. DAN was found to provide superior ionization to the compared matrices for MW < similar to 400 Da; however, 9-aminoacridine (9-AA) was found to be superior for a uridine diphosphate standard (MW 566 Da). DAN was also found to provide a more representative profile of a natural phospholipid mixture than 9-AA. Finally, DAN and 9-AA were applied for imaging of metabolites directly from corn leaf sections. Published 2014. This article is a U. S. Government work and is in the public domain in the USA.
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