期刊
JOURNAL OF MASS SPECTROMETRY
卷 45, 期 7, 页码 734-739出版社
WILEY
DOI: 10.1002/jms.1763
关键词
VUV photoionization mass spectrometry; laser desorption; antipyrine; propyphenazone; fragmentation pathway
资金
- Chinese Academy of Sciences [YZ200764]
- Natural Science Foundation of China [10705026, 10805047, 50925623]
Two analgesic and anti-inflammatory drugs, antipyrine and propyphenazone, were investigated with infrared laser desorption/tunable synchrotron vacuum ultraviolet (VUV) photoionization mass spectrometry (IR LD/VUV PIMS) and theoretical calculations. Mass spectra of the two drugs were measured at various photon energies. Fragment ions were gradually produced as photon energy increases. The structural assignment of the dominant fragment ions was supported by the results from a commercial electron impact time-of-flight mass spectrometer (EI-TOF MS). Primary fragmentation pathways were established from experimental observations combining with theoretical calculations. Methyl radical elimination is a common fragmentation pathway for two analytes. However, for propyphenazone cation, isopropyl group elimination to form antipyrine cation is another competitive pathway. Copyright (C) 2010 John Wiley & Sons, Ltd.
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