Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Food Science & Technology
Pablo-Jesus Marin-Garcia, Nuria Planas, Lola Llobat
Summary: This article reviews the detection methods, prevalence, and control measures of Toxoplasma gondii in the food industry. T. gondii is a common parasite that causes infection through food contamination, but standardized detection methods are currently lacking in the industry. The main detection methods include bioassays, cell culture, molecular and microscopic techniques, and serological methods. Due to the high prevalence of T. gondii in many food products, standardized detection methods and control measures are necessary.
Article
Immunology
Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar
Summary: Toxoplasma gondii infection is associated with immune response, which can be used as prognosis markers. Immunotherapy has become a new approach for toxoplasmosis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Parasitology
Jiaofeng Huang, Jiaolong Zheng, Bang Liu, Lingling Lu, Haicong Wu, Su Lin, Dongliang Li
Summary: This study found that Toxoplasma gondii infection is associated with higher mortality in the general population, and this association is related to age and sex. This suggests that Toxoplasma gondii infection may be an important public health issue.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Syrian G. Sanchez, Emilie Bassot, Aude Cerutti, Hoa Mai Nguyen, Amel Aida, Nicolas Blanchard, Sebastien Besteiro
Summary: Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. The study finds that targeting the apicoplast in bradyzoites, the latent form of the parasite, leads to a loss of long-term viability, suggesting the apicoplast as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Hira Mohyuddin, Blanca Laffon, Joao P. Teixeira, Solange Costa, Armanda Teixeira-Gomes, Eduardo Pasaro, Niel Constantine, Aline Dagdag, Heidi K. Ortmeyer, Boris Tizenberg, Liubov Afram, Poyu Yen, Christopher Marano, Christopher A. Lowry, Andrew J. Hoisington, Jill A. Rachbeisel, Vanessa Valdiglesias, Carlota Lema-Arranz, Natalia Fernandez-Bertolez, Ana Maseda, Jose C. Millan-Calenti, Elizabeth J. Kovacs, Johanna M. Gostner, Dietmar Fuchs, Lisa A. Brenner, Laura Lorenzo-Lopez, Teodor T. Postolache
Summary: This study revealed an association between Toxoplasma gondii and frailty, but further research is needed for validation. Certain biomarkers related to inflammaging were associated with both Toxoplasma gondii and frailty, but they did not fully mediate the association between the two.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Amy C. Schumacher, Lina Elbadawi, Traci DeSalvo, Anne Straily, Daniel Ajzenberg, David Letzer, Ellen Moldenhauer, Tammy L. Handly, Dolores Hill, Marie-Laure Darde, Christelle Pomares, Karine Passebosc-Faure, Kristine Bisgard, Carlos A. Gomez, Cindy Press, Stephanie Smiley, Jose G. Montoya, James J. Kazmierczak
Summary: In 2017, an outbreak of toxoplasmosis was linked to undercooked venison served at a retreat in Wisconsin. Most of the attendees experienced illness, with laboratory results showing atypical features for toxoplasmosis. The strain of T. gondii found in the venison was a unique genotype, highlighting the potential risks of consuming undercooked game meat in North America.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Thais Cabral Monica, Fernanda Evers, Beatriz Souza Lima Nino, Fernanda Pinto-Ferreira, Jose Wander Bregano, Mariana Ragassi Urbano, Guita Rubinsky-Elefant, Roberta Lemos Freire, Italmar Teodorico Navarro, Regina Mitsuka-Bregano
Summary: The study examined the seroprevalence and risk factors of toxoplasmosis and toxocariasis in schoolchildren in Jataizinho, Parana, revealing associations with factors such as the mother's education level, age, presence of cats in the household, income, and presence of dogs. There was also an association between the two zoonoses, highlighting the importance of implementing control measures to reduce the incidence and risks of sequelae in children.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ragab M. Fereig, Yoshifumi Nishikawa
Summary: In this study, the cyto-nuclear and mitochondrial localization of TgPrx1 and TgPrx3 proteins in Toxoplasma gondii were revealed. Knocking out TgPrx1 and TgPrx3 genes in T. gondii resulted in decreased survival rate in mice infected with TgPrx3KO strain compared to TgPrx1KO and control strains. Additionally, TgPrx1KO and TgPrx3KO induced high levels of interferon gamma (IFN-gamma) and increased IL-6 and IL-12p40 production in infected mice and murine macrophages. These findings suggest that TgPrx3 may be a potential sub-unit vaccine candidate for controlling toxoplasmosis in susceptible humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lokman Galal, Frederic Ariey, Meriadeg Ar Gouilh, Marie-Laure Darde, Azra Hamidovic, Franck Letourneur, Franck Prugnolle, Aurelien Mercier
Summary: This study analyzes 156 genomes of Toxoplasma gondii and provides estimates of the parasite's mutation rate and generation time. It reveals that a specific haplotype is associated with the spread of the parasite through cats, indicating its role in sexual reproduction.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Rajib Acharjee, Keith K. Talaam, Endah D. Hartuti, Yuichi Matsuo, Takaya Sakura, Bundutidi M. Gloria, Shinya Hidano, Yasutoshi Kido, Mihoko Mori, Kazuro Shiomi, Masakazu Sekijima, Tomoyoshi Nozaki, Kousuke Umeda, Yoshifumi Nishikawa, Shinjiro Hamano, Kiyoshi Kita, Daniel K. Inaoka
Summary: Toxoplasma gondii is a protozoan parasite that infects a large portion of the global human population. A new potential drug target, TgMQO, has been identified in this study, and a novel expression system was developed to study its characteristics. Ferulenol, an MQO inhibitor, showed promising inhibitory effects on TgMQO, with distinct binding sites from other known inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Ningbo Xia, Nuo Ji, Longjiao Li, Yuan Huang, Congshan Yang, Xuefang Guo, Qinghong Guo, Bang Shen, Lihua Xiao, Yaoyu Feng
Summary: This study investigated the seroprevalence and risk factors of T. gondii infection in cats across China. The study found higher infection rates in Sichuan, Chongqing, and Hunan, and reported the seroprevalence in Qinghai, Anhui, Jiangxi, Shaanxi, and Ningxia for the first time. Age and lifestyle (stray or pet) of cats were identified as risk factors for T. gondii infection.
BMC VETERINARY RESEARCH
(2022)
Review
Infectious Diseases
Tahereh Mikaeili Galeh, Shahabeddin Sarvi, Seyed Abdollah Hosseini, Ahmad Daryani
Summary: Toxoplasmosis, caused by Toxoplasma gondii, is a common food-borne infection in humans. In rodent populations, atypical genotypes are dominant, while clonal strains circulate with low genetic diversity in this mammal species.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Yazhen Ma, Xinru Cao, Hui Wang, Xingju Song, Dandan Hu
Summary: Tilmicosin and acetylisovaleryltylosin tartrate (ATLL) have potent anti-Toxoplasma activities, inhibiting the growth and proliferation of the parasite. ATLL shows strong inhibitory effects on intracellular parasites, while tilmicosin suppresses extracellular parasites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Syrian G. Sanchez, Sebastien Besteiro
Summary: Toxoplasma gondii is a parasitic protist that can infect a wide range of warm-blooded animals and may lead to severe outcomes in immunocompromised individuals or developing fetuses. The parasite can persist in the host and reactivate from encysted forms, which are resistant to medication. The clinical outcome of toxoplasmosis is influenced by the balance between host immune response and parasite virulence factors.
Article
Parasitology
Kiswendsida Thierry Guiguemde, Patindoilba Marcel Sawadogo, Adama Zida, Apollinaire Kima, Roland Windtare Bougma, Mamadou Serme, Ibrahim Sangare, Clarisse Bougouma, Sanata Bamba
Summary: This study assessed the transmission of onchocerciasis in the Cascades region of Burkina Faso and found that the resumption of ivermectin treatment has significantly reduced the prevalence of the disease since 2011.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
K. D. Steffen, M. L. Gos, J. M. Unzaga, M. C. Venturini, R. O. Ariasc, G. More
Summary: The dynamics of anti-T. gondii antibodies and seroconversion in naturally infected goats from the last third of pregnancy to 100 days of lactation were evaluated, and their relationship with hematological and dehydration parameters was examined. The results showed that seroconversion occurred in goats of different physiological states and ages, and it was not related to hydration status.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Maho Kotake, Yuho Watanabe, Naoki Itoh, Tomoyoshi Yoshinaga
Summary: This study examined the effects of light exposure on the theront excystment circadian rhythm in Cryptocaryon irritans. The results showed that light reception is essential for circadian rhythm entrainment and both light duration and temperature have an impact on the entrainment of circadian rhythm.
PARASITOLOGY INTERNATIONAL
(2024)
Review
Parasitology
Olivier Ndogo Eteme, Ernestine Nkwengoua Zondegoumba, Yasmin Saegusa Tadayozzi, Jessica Aparecida Serafim, Wendell Queiroz Leite, Mariane de Freitas Genari Severino, Eduardo Festozo Vicente
Summary: The high mortality rate caused by parasitic worms on their hosts is a major concern. Current drugs on the market are often toxic with numerous side effects, necessitating the search for new, more potent molecules. Medicinal plants have been found to contain a wide range of novel molecules that can effectively combat different types of helminths. This review provides an overview of the methods, activities, and mechanisms of action of cyclic peptides, specifically cyclotides, for treating helminthic infections.
PARASITOLOGY INTERNATIONAL
(2024)
Article
Parasitology
Lucas de Assis Silva Andrade, Carlos Nei Ortuzar-Ferreira, Mariana de Souza Oliveira, Sergian Vianna Cardozo, Viviane Moreira de Lima, Bruno Pereira Berto
Summary: A new species of Isospora Schneider, 1881 has been identified from V. chivi in Southeastern Brazil. Morphological and molecular analyses confirmed the identity of this new species.
PARASITOLOGY INTERNATIONAL
(2024)