Review
Nutrition & Dietetics
Giuseppe Chiarioni, Stefan Lucian Popa, Abdulrahman Ismaiel, Cristina Pop, Dinu Iuliu Dumitrascu, Vlad Dumitru Brata, Traian Adrian Duse, Victor Incze, Teodora Surdea-Blaga, Jose Antonio Uranga
Summary: This systematic review evaluates the efficacy and safety of herbal remedies in the management of IBS-C. The included studies demonstrate some evidence of the beneficial effects of herbal remedies on IBS-C symptoms. However, the heterogeneity of the interventions and outcome measures limits the ability to perform a meta-analysis.
Article
Medicine, General & Internal
Juan J. Sebastian Domingo
Summary: Irritable bowel syndrome is a common functional bowel disorder with significant impact on patients' daily lives and society's economy. It is characterized by abdominal pain, bloating, and altered bowel movements, and its etiology and pathophysiological mechanism are still unknown.
Review
Medicine, General & Internal
Sarah Patel, Bethany Doerfler, Katerine Boutros, Samson Ng, Machelle Manuel, Elayne DeSimone
Summary: IBS-C and CIC are common disorders of gut-brain interaction, presenting with symptoms such as constipation, abdominal pain, and bloating that significantly impact quality of life. Family medicine practitioners are uniquely qualified to diagnose and manage these conditions.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Andrea Shin, Huiping Xu, Thomas F. Imperiale
Summary: IBS is prevalent among veterans and is associated with anxiety, depression, and lower quality of life. Provisional PTSD, infectious enteritis (IE), and bowel problems after antibiotics are more common in patients with IBS. IBS has a measurable impact on individuals and healthcare resources.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Nutrition & Dietetics
Xue Shang, E. Fen-Fen, Kang-Le Guo, Yan-Fei Li, Hong-Lin Zhao, Yan Wang, Nan Chen, Tao Nian, Chao-Qun Yang, Ke-Hu Yang, Xiu-Xia Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of probiotics in treating constipation-predominant irritable bowel syndrome (IBS-C). The findings suggest that probiotics can improve stool consistency and increase the number of Bifidobacteria and Lactobacilli in feces with good safety. However, the certainty of the evidence is low and more high-quality studies are needed to verify the results.
Article
Gastroenterology & Hepatology
Christopher Ma, Stephen E. Congly, Kerri L. Novak, Paul J. Belletrutti, Maitreyi Raman, Matthew Woo, Christopher N. Andrews, Yasmin Nasser
Summary: The management of chronic symptomatic functional bowel disorders (FBDs) in the United States incurs considerable healthcare resource use and cost, with pharmacologic therapies being more commonly prescribed than nonpharmacologic interventions. Combination treatment strategies are more likely to be implemented by primary care physicians, highlighting the need to improve comprehensive FBD management.
Review
Medicine, General & Internal
Lynne McFarland, Tarkan Karakan, Ali Karatas
Summary: After screening 521 studies, 42 randomized controlled trials were included in this study, with 4 probiotics showing significant reduction in abdominal pain, particularly B. coagulans MTCC5260. Mild-moderate adverse events were reported in 51% of the trials, but none were more associated with the probiotics compared to controls.
Article
Medicine, General & Internal
Oana-Bogdana Barboi, Ioan Chirila, Irina Ciortescu, Carmen Anton, Vasile-Liviu Drug
Summary: This study suggests that a specific constipation diet combined with inulin, choline, and silymarin can have significant clinical benefits on IBS patients with constipation, improving bowel movement, abdominal pain, and bloating symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Behavioral Sciences
Joseph Sullivan, Alison M. Deighton, Maria Candida Vila, Shelagh M. Szabo, Benit Maru, Jacqueline S. Gofshteyn, Emma S. James, Salvador Rico, Sameer M. Zuberi
Summary: Dravet syndrome is a developmental and epileptic encephalopathy characterized by a changing disease course as individuals age. There is a lack of comprehensive systematic review of the contemporary literature on DS, but available evidence indicates that it is not limited to seizures; non-seizure manifestations appear early in life and increase over time, significantly contributing to the burden of the disease on individuals, families, and healthcare systems. The HRQoL in DS is primarily affected by seizure severity, cognition, and motor and behavioral problems.
EPILEPSY & BEHAVIOR
(2022)
Article
Medicine, General & Internal
Zahid Ijaz Tarar, Umer Farooq, Yousaf Zafar, Mustafa Gandhi, Samina Raza, Faisal Kamal, Moosa F. Tarar, Yezaz A. Ghouri
Summary: This study investigated the burden of psychiatric disorders in patients with irritable bowel syndrome (IBS). The study found that anxiety, depression, and suicide attempt/ideation were significantly more prevalent in IBS patients. IBS patients were also associated with higher odds of anxiety, depression, and suicidal attempt/ideation, and had longer hospital stays when with a co-diagnosis of anxiety or depression.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Gastroenterology & Hepatology
Sameer K. Berry, Rani Berry, David Recker, Jeffrey Botbyl, Lucy Pun, William D. Chey
Summary: Digital gut-directed hypnotherapy (GDH) treatment program can improve symptoms of IBS, including abdominal pain and stool problems. There was no significant difference in effectiveness between digital GDH and digital muscle relaxation (MR), but the GDH treatment group had more abdominal pain responders.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Theodora Kalli, Tilemachos Koutouratsas, George Karamanolis, Maria Gazouli
Summary: The study found a significant association between the rs696217 genetic polymorphism and IBS susceptibility, with the GG and GT genotypes as well as the G allele being linked to IBS risk, while the T allele may have a protective effect. There was no correlation between ghrelin gene polymorphisms and different IBS subtypes.
Review
Gastroenterology & Hepatology
Vivek C. Goodoory, Mais Khasawneh, Christopher J. Black, Eamonn M. M. Quigley, Paul Moayyedi, Alexander C. Ford
Summary: This article conducted a meta-analysis to study the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). The study found that certain combinations of probiotics or strains may be beneficial for IBS, but the certainty of the evidence was low.
Review
Pharmacology & Pharmacy
Hyejin Jun, Seok-Jae Ko, Keumji Kim, Jinsung Kim, Jae-Woo Park
Summary: This study assessed the methodology and quality of evidence of systematic reviews (SRs) on the use of herbal medicines (HMs) for irritable bowel syndrome (IBS). The findings suggest that HM can be considered as an effective and safe treatment for IBS. However, the methodological quality of the included SRs and the quality of evidence were generally low. Well-designed randomized controlled trials are needed to better evaluate the safety and efficacy of HM in IBS treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Giovanni Marasco, Cesare Cremon, Maria Raffaella Barbaro, Giulia Cacciari, Francesca Falangone, Anna Kagramanova, Dmitry Bordin, Vasile Drug, Egidia Miftode, Pietro Fusaroli, Salem Youssef Mohamed, Chiara Ricci, Massimo Bellini, Mohammed Masudur Rahman, Luigi Melcarne, Javier Santos, Beatriz Lobo, Serhat Bor, Suna Yapali, Deniz Akyol, Ferdane Pirincci Sapmaz, Yonca Yilmaz Urun, Tugce Eskazan, Altay Celebi, Huseyin Kacmaz, Berat Ebik, Hatice Cilem Binicier, Mehmet Sait Bugdayci, Munkhtsetseg Banzragch Yagci, Husnu Pullukcu, Berrin Yalinbas Kaya, Ali Tureyen, Ibrahim Hatemi, Elif Sitre Koc, Goktug Sirin, Ali Riza Caliskan, Goksel Bengi, Esra Ergun Alis, Snezana Lukic, Meri Trajkovska, Keren Hod, Dan Dumitrascu, Antonello Pietrangelo, Elena Corradini, Magnus Simren, Jessica Sjoelund, Navkiran Tornkvist, Uday C. Ghoshal, Olga Kolokolnikova, Antonio Colecchia, Jordi Serra, Giovanni Maconi, Roberto De Giorgio, Silvio Danese, Piero Portincasa, Antonio Di Sabatino, Marcello Maggio, Elena Philippou, Yeong Yeh Lee, Daniele Salvi, Alessandro Venturi, Claudio Borghi, Marco Zoli, Paolo Gionchetti, Pierluigi Viale, Vincenzo Stanghellini, Giovanni Barbara
Summary: This study aimed to evaluate the prevalence of gastrointestinal symptoms and post-COVID-19 disorders of gut-brain interaction among hospitalized patients with SARS-CoV-2 infection. The results showed that patients with COVID-19 had higher rates of gastrointestinal symptoms on hospital admission and lower rates of constipation and hard stools at 12 months post-infection compared to the control group. Additionally, the rate of irritable bowel syndrome was significantly higher in patients with COVID-19 than in controls.