Article
Anatomy & Morphology
Alika Lopatka, Anne M. Moon
Summary: The limb phenotypes of Tbx2 and Tbx3 mutants are distinct, and sequential loss of alleles results in compound sensitivity to decreased gene dosage in multiple structures of both forelimb and hindlimb.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Oncology
Tarryn Willmer, Victoria Damerell, Shannon Smyly, Danica Sims, Michelle Du Toit, Stephanie Ncube, Musalula Sinkala, Dhirendra Govender, Edward Sturrock, Jonathan M. Blackburn, Sharon Prince
Summary: The study identifies TBX3 as upregulated in various sarcoma subtypes and requiring nucleolin as a cofactor to promote sarcomagenesis. Disruption of the TBX3-nucleolin interaction by AS1411 shows selective anti-cancer activity in sarcoma cells, providing a novel approach for treating sarcomas.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Binyong Liang, Yi Zhou, Manning Qian, Meng Xu, Jingxiao Wang, Yi Zhang, Xinhua Song, Haichuan Wang, Shumei Lin, Chuanli Ren, Satdarshan P. Monga, Bruce Wang, Matthias Evert, Yifa Chen, Xiaoping Chen, Zhiyong Huang, Diego F. Calvisi, Xin Chen
Summary: TBX3 is induced by GOF CTNNB1 mutants and suppresses HCC growth by inactivating PLD1, thus leading to the inhibition of YAP/TAZ oncogenes. This indicates that TBX3 may act as a tumor suppressor gene in liver cancer and strategies to increase TBX3 expression could be effective for HCC treatment.
JOURNAL OF HEPATOLOGY
(2021)
Article
Genetics & Heredity
Katarzyna Bzdega, Mateusz Biela, Gail H. Deutsch, Joseph A. Kitzmiller, Malgorzata Rydzanicz, Rafal Ploski, Jeffrey A. Whitsett, Robert Smigiel, Justyna A. Karolak
Summary: Congenital alveolar dysplasia (CAD) is a rare and lethal lung developmental disorder characterized by respiratory failure and pulmonary arterial hypertension. Most CAD cases are associated with copy-number variant (CNV) deletions at 17q23.1q23.2 or 5p12. This study reports a novel non-recurrent CNV deletion involving TBX4 gene in a CAD patient, providing evidence that perturbations in TBX4, rather than TBX2, cause severe lung phenotypes in humans.
Article
Toxicology
Yi Liu, Guanghui Chen, Hui Wang
Summary: Decreased sperm quality in male infertility is linked to prenatal dexamethasone exposure (PDE) in this study. PDE was found to decrease sperm count and motility, and increase deformity rate in male offspring. The expression of connexin 43 (CX43) in offspring testes was also reduced. These findings demonstrate the epigenetic programming of TBX2/CX43 in Sertoli cells as a mechanism by which PDE affects sperm quality in male offspring.
TOXICOLOGICAL SCIENCES
(2023)
Article
Veterinary Sciences
Sheng-Peng Li, Hao Jiang, Zi-Bin Liu, Wen-Jie Yu, Xiao-Shi Cai, Chang Liu, Wen-Yin Xie, Fu-shi Quan, Wei Gao, Nam-Hyung Kim, Bao Yuan, Cheng-Zhen Chen, Jia-Bao Zhang
Summary: TBX2 plays important roles in regulating the proliferation, expansion, apoptosis, and autophagy of bovine cumulus cells. It also maintains the mitochondrial function and cholesterol generation of these cells.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Oncology
Ghodeejah Higgins, Faatiemah Higgins, Jade Peres, Dirk M. Lang, Tamer Abdalrahman, Muhammad H. Zaman, Sharon Prince, Thomas Franz
Summary: Cell stiffness and TBX3 expression are biomarkers of melanoma metastasis in 2D environments. Soft extracellular environments are more favorable for tumor growth. TBX3 mediates collective cell migration and tumor growth in the early VGP disease stage but plays a lesser role in the later metastatic stage of melanoma.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Multidisciplinary Sciences
James R. W. Conway, Defne D. Dinc, Gautier Follain, Oona Paavolainen, Jasmin Kaivola, Pia Bostroem, Pauliina Hartiala, Emilia Peuhu, Johanna Ivaska
Summary: The progression from noninvasive ductal carcinoma in situ to invasive ductal carcinoma in breast cancer patients has a negative impact on prognosis and can lead to metastasis. Insulin-like growth factor-binding protein 2 (IGFBP2) secreted by healthy breast adipocytes has been identified as a potent adipocrine factor that acts as a barrier against invasive progression. Adipocytes derived from patient stromal cells were found to secrete IGFBP2, which effectively inhibited breast cancer invasion by sequestering cancer-derived IGF-II. Depleting IGF-II in invading cancer cells using RNAs or an IGF-II-neutralizing antibody prevented breast cancer invasion, emphasizing the importance of IGF-II autocrine signaling in invasive progression.
Article
Mathematical & Computational Biology
Lifu Huang, Xianjun Zhang, Feiping Li, Xiaohong Wang
Summary: This study provides new insight into bladder cancer therapy by investigating the microRNA-143-3p/TBX3 axis. The results suggest that TBX3 is highly expressed in bladder cancer cells and is regulated by microRNA-143-3p. TBX3 acts as a cancer promoter gene, affecting tumor proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in bladder cancer.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kiley Graim, Dmitriy Gorenshteyn, David G. Robinson, Nicholas J. Carriero, James A. Cahill, Rumela Chakrabarti, Michael H. Goldschmidt, Amy C. Durham, Julie Funk, John D. Storey, Vessela N. Kristensen, Chandra L. Theesfeld, Karin U. Sorenmo, Olga G. Troyanskaya
Summary: Studying canine mammary tumors can model molecular changes in human breast cancer, improving diagnostics and treatments. Utilizing multiple canine tumor samples reveals specific biological pathways of malignant tumors compared to benign and normal tissues. Research indicates that multiple histological samples per patient are crucial for capturing disease progression-related features in human breast cancer.
Article
Endocrinology & Metabolism
Lili Li, Genbao Zhu, Kemeng Tan, La Jiang, Yafen Li, Xiaohong Zhu, Zongwu Lin, Xinghai Zhang, Jie Chen, Chengquan Ma
Summary: This study reveals that CUX2 is highly expressed in BC, while KDM5B and SOX17 are relatively low. Inhibition of CUX2 suppresses the malignant behaviors of BC cells by activating KDM5B and suppressing SOX17 expression. This suggests that CUX2 plays a role in tumorigenesis and progression of BC through the KDM5B/SOX17 axis.
Review
Oncology
Madison N. Wicker, Kay-Uwe Wagner
Summary: Cellular plasticity, the ability of cells to change their identity, plays a crucial role in mammary gland development and breast cancer progression. This review provides a comprehensive overview of the factors and mechanisms that promote cellular plasticity in the mammary gland. It discusses changes in cell identity during normal development, the role of the gestation cycle, and highlights the importance of the microenvironment and extracellular matrix. The review also explores cellular reprogramming during mammary tumorigenesis, focusing on the origin of basal-like breast cancers and the role of oncogenic signaling networks. Additionally, recent advances in genetically engineered models to study cellular plasticity in vivo are discussed.
Review
Biochemistry & Molecular Biology
Diana Wu, Lilian U. Thompson, Elena M. Comelli
Summary: Breast cancer, the second most common cancer in women after skin cancer, can be influenced by mammary gland development. miRNAs play a key role in both mammary development and breast cancer, and studying their role in development may provide insights into potential targets for breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Yuanzhong Pan, Pauline J. J. van der Watt, Steve A. A. Kay
Summary: E-boxes are important elements in regulating gene transcription, and E-box-binding transcription factors (EBTFs) play essential roles in development and cellular activities. Studies have shown the fundamental role of EBTFs in cancer, but there is a lack of comprehensive analysis on TFs that bind to E-boxes. This review focuses on the structure and function of EBTFs, their common features, their regulation, their roles in cancer biology, potential as a regulatory network, and recent progress in drug development targeting these factors in cancer therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Developmental Biology
Hansoo Song, Bernice E. Morrow
Summary: Through single cell RNA-sequencing analysis of Tbx2/3-deficient embryos, we found that Tbx2/3 plays a promoting role in the transition of otic vesicle cells to different states. Loss of Tbx2/3 leads to failed differentiation of otic vesicle cells into inner ear organs, as well as disrupted neural cell development.
DEVELOPMENTAL BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Lisa C. Grossman, Lauren Zakarin Safier, Melissa D. Kline, Cariann W. Chan, Rogerio A. Lobo, Mark V. Sauer, Nataki C. Douglas
JOURNAL OF WOMENS HEALTH
(2017)
Article
Developmental Biology
Heather I. Levin, Chantae S. Sullivan-Pyke, Virginia E. Papaioannou, Ronald J. Wapner, Jan K. Kitajewski, Carrie J. Shawber, Nataki C. Douglas
Article
Biology
Daniel Concepcion, Andrew J. Washkowitz, Akiko DeSantis, Phillip Ogea, Jason I. Yang, Nataki C. Douglas, Virginia E. Papaioannou
Article
Biochemistry & Molecular Biology
Jennifer L. Sones, Audrey A. Merriam, Angelina Seffens, Dex-Ann Brown-Grant, Scott D. Butler, Anna M. Zhao, Xinjing Xu, Carrie J. Shawber, Jennifer K. Grenier, Nataki C. Douglas
Article
Cell Biology
Dorien Reijnders, Chin-Chi Liu, Xinjing Xu, Anna M. Zhao, Kelsey N. Olson, Scott D. Butler, Nataki C. Douglas, Jenny L. Sones
PHYSIOLOGICAL GENOMICS
(2018)
Article
Biology
Daniel Concepcion, Hiroshi Hamada, Virginia E. Papaioannou
Article
Obstetrics & Gynecology
Erin E. Burke, Safedin Beqaj, Nataki C. Douglas, Robert Luo
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Biology
Carrie J. Shawber, Dex-Ann Brown-Grant, Tracy Wu, Jan K. Kitajewski, Nataki C. Douglas
Article
Obstetrics & Gynecology
Shweta J. Bhatt, Nataki Douglas
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Letter
Obstetrics & Gynecology
Erin Burke, Safedin Beqaj, Nataki Douglas
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Cell Biology
Salma Begum, Barry E. Perlman, Nuriban Valero-Pacheco, Valerie O'Besso, Tracy Wu, Sara S. Morelli, Aimee M. Beaulieu, Nataki C. Douglas
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Nicole M. Marchetto, Salma Begum, Tracy Wu, Valerie O'Besso, Christina C. Yarborough, Nuriban Valero-Pacheco, Aimee M. Beaulieu, Jan K. Kitajewski, Carrie J. Shawber, Nataki C. Douglas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biology
Kelsey N. Olson, Dorien Reijnders, Viviane C. L. Gomes, R. Caitlin Hebert, Chin-Chi Liu, Jacqueline M. Stephens, Leanne M. Redman, Nataki C. Douglas, Jennifer L. Sones
Letter
Obstetrics & Gynecology
Lauren Z. Safier, Mark V. Sauer, Nataki C. Douglas
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)