期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 323, 期 10, 页码 1404-1407出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2010.11.059
关键词
Cancer treatment; Nanoparticle; Local chemotherapy
The aim of magnetic drug targeting (MDT) in cancer therapy is to concentrate chemotherapeutics to a tumor region while simultaneously the overall dose is reduced. This can be achieved with coated superparamagnetic nanoparticles bound to a chemotherapeutic agent. These particles are applied intra arterially close to the tumor region and focused to the tumor by a strong external magnetic field. The interaction of the particles with the field gradient leads to an accumulation in the region of interest (i.e. tumor). The particle enrichment and thereby the drug-load in the tumor during MDT has been proven by several analytical and imaging methods. Moreover, in pilot studies we investigated in an experimental in vivo tumor model the effectiveness of this approach. Complete tumor regressions without any negative side effects could be observed. (C) 2010 Elsevier B.V. All rights reserved.
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