期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 321, 期 10, 页码 1686-1688出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2009.02.115
关键词
Magnetic nanoparticle; Full-automation; Chemiluminescent enzyme immunoassay; Thyroid-stimulating hormone; Light emission
The magnetic nanoparticles (MNPs) Therma-Max (TM) were used as a carrier to develop an automated sandwich chemiluminescent enzyme immunoassay (CLEIA) to detect thyroid-stimulating hormone (TSH) in a sensitive and specific way. The Therma-Max (TM) particles allow for automation because, unlike magnetic microspheres, they are completely dispersed in aqueous solution and allow for accurate automatic handling. Signal intensities detected with MNPs were 8-fold higher than those found with conventional micron-sized magnetic particles. A reproducibility study suggests that these particles allow for a stable detection method, as the coefficient of variation(CV) is less than 6% (n = 10). (C) 2009 Elsevier B.V. All rights reserved.
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