期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 41, 期 2, 页码 369-375出版社
WILEY-BLACKWELL
DOI: 10.1002/jmri.24572
关键词
MR elastography; feasibility; pancreas; healthy volunteers
资金
- NIH [EB001981]
- National Natural Science Foundation of China [81271566]
PurposeTo evaluate the feasibility of using three-dimensional (3D) MR elastography (MRE) to determine the stiffness of the pancreas in healthy volunteers. Materials and MethodsTwenty healthy volunteers underwent 1.5 Tesla MRE exams using an accelerated echo planar imaging (EPI) pulse sequence with low-frequency vibrations (40 and 60 Hz). Stiffness was calculated with a 3D direct inversion algorithm. The mean shear stiffness in five pancreatic subregions (uncinate, head, neck, body, and tail) and the corresponding liver stiffness were calculated. The intrasubject coefficient of variation (CV) was calculated as a measure of the reproducibility for each volunteer. ResultsThe mean shear stiffness (average of values obtained in different pancreatic subregions) was (1.150.17) kPa at 40 Hz, and (2.09 +/- 0.33) kPa at 60 Hz. The corresponding liver stiffness was higher than the pancreas stiffness at 40 Hz ([1.60 +/- 0.21] kPa, mean pancreas-to-liver stiffness ratio: 0.72), but similar at 60Hz ([2.12 +/- 0.23) kPa, mean ratio: 0.95). The mean intrasubject CV for each pancreatic subregion was lower at 40 Hz than 60 Hz (P<0.05 for all subregions, range: 11.9-15.7% at 40 Hz and 16.5-19.6% at 60 Hz). ConclusionThe 3D pancreatic MRE can provide promising and reproducible stiffness measurements throughout the pancreas, with more consistent data acquired at 40 Hz. J. Magn. Reson. Imaging 2015;41:369-375.(c) 2013 Wiley Periodicals, Inc.
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