Article
Radiology, Nuclear Medicine & Medical Imaging
Shiori Amemiya, Yusuke Watanabe, Naoyuki Takei, Tsuyoshi Ueyama, Satoru Miyawaki, Satoshi Koizumi, Seiji Kato, Hidemasa Takao, Osamu Abe, Nobuhito Saito
Summary: The study found that in severe steno-occlusive diseases, the Combo strategy using ATT correction can improve CBF measurement accuracy, and VS significantly enhances CBF measurement accuracy in standard protocol and in moyamoya patients for the Combo.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyuan Fan, Zhentao Zuo, Tianye Lin, Zhichao Lai, Hui You, Jianxun Qu, Juan Wei, Bao Liu, Feng Feng
Summary: The study aimed to investigate whether preoperative arterial spin labeling (ASL) MRI can predict cerebral hyperperfusion after carotid endarterectomy (CEA) in patients with carotid stenosis. The study found that ASL can non-invasively predict cerebral hyperperfusion after CEA in patients with carotid stenosis based on the presence of arterial transit artifacts (ATAs).
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Tingting Zhang, Haijun Niu, Yawen Liu, Linkun Cai, Dong Liu, Erwei Zhao, Min Li, Wenjuan Liu, Jing Li, PengGang Qiao, Wei Zheng, Pengling Ren, Zhenchang Wang
Summary: This study investigated the effects of dobutamine on cerebral hemodynamics and found that dobutamine stress significantly decreased cerebral blood flow in the frontal lobe anterior circulation. Additionally, body mass index, resting systolic blood pressure, and basilar artery diameter were significantly associated with changes in frontal lobe cerebral blood flow.
Article
Radiology, Nuclear Medicine & Medical Imaging
James H. Holmes, Mu-Lan Jen, Laura B. Eisenmenger, Tilman Schubert, Patrick A. Turski, Kevin M. Johnson
Summary: This study introduces a mapping approach to investigate the relative tagging efficiency of VS-ASL, validated through numerical simulations and experiments. Unique efficiency patterns were observed in normal volunteers based on individual anatomy and physiology. While uniform tagging efficiency was generally seen in vivo, regions of high blood velocity and local susceptibility gradients showed reduced efficiency.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Qin Qin, David C. Alsop, Divya S. Bolar, Luis Hernandez-Garcia, James Meakin, Dapeng Liu, Krishna S. Nayak, Sophie Schmid, Matthias J. P. van Osch, Eric C. Wong, Joseph G. Woods, Greg Zaharchuk, Moss Y. Zhao, Zungho Zun, Jia Guo
Summary: This review article provides an overview of the current status of velocity-selective arterial spin labeling (VSASL) perfusion MRI and discusses its concepts, implementation, clinical applications, and technical challenges.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
Xiao-Hui Wang, Xiao-Fan Liu, Min Ao, Ting Wang, Jinglan He, Yue-Wen Gu, Jing-Wen Fan, Li Yang, Renqiang Yu, Shuliang Guo
Summary: This study aims to explore the cerebral perfusion pattern and blood flow status of anxiety in patients with pulmonary nodules, and found significant differences between the anxiety group and the non-anxiety group. By detecting the cerebral blood flow in specific brain regions, the anxiety group can be accurately distinguished from the non-anxiety group.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xinyu Wang, Weiqiang Dou, Dong Dong, Xinyi Wang, Xueyu Chen, Kunjian Chen, Huimin Mao, Yu Guo, Chao Zhang
Summary: This study aimed to explore the feasibility of three-dimensional pseudo-continuous arterial-spin-labeling (tASL) in evaluating MCA recanalization. After recanalization, tASL provided good prognosis and was found to be an independent predictor of good clinical outcome.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Oncology
Abir Troudi, Fatima Tensaouti, Eloise Baudou, Patrice Peran, Anne Laprie
Summary: This article introduces the magnetic resonance imaging techniques for pediatric brain tumors, especially the ASL MRI technique in evaluating treatment response and neurocognitive sequelae. ASL is a noninvasive technique for measuring cerebral blood flow, but it has some drawbacks and technical requirements.
Article
Radiology, Nuclear Medicine & Medical Imaging
Nicholas J. Luciw, Zahra Shirzadi, Sandra E. Black, Maged Goubran, Bradley J. MacIntosh
Summary: This study developed and evaluated a deep learning approach to estimate CBF and ATT from multiple PLD ASL MRI. Different convolutional neural network architectures were trained and compared, and the U-Net model showed better performance. The U-Net model had lower MAE on both training and test data, and demonstrated good generalizability.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Physiology
Hanne Stotesbury, Patrick W. Hales, Anna M. Hood, Melanie Koelbel, Jamie M. Kawadler, Dawn E. Saunders, Sati Sahota, David C. Rees, Olu Wilkey, Mark Layton, Maria Pelidis, Baba P. D. Inusa, Jo Howard, Subarna Chakravorty, Chris A. Clark, Fenella J. Kirkham
Summary: This study used ASL techniques to investigate cerebral blood flow and bolus arrival time in SCA patients, finding associations between increased CBF, reduced BAT, and decreased arterial oxygen content. Differences were observed between sequences in iWSAs, and CBF in iWSAs was related to lesion burden, microstructural tissue integrity, and processing speed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hossein Rahimzadeh, Hadi Kamkar, Narges Hoseini-Tabatabaei, Neda Mohammadi Mobarakeh, Jafar Mehvari Habibabadi, Seyed-Sohrab Hashemi-Fesharaki, Mohammad-Reza Nazem-Zadeh
Summary: Summary in English: This study aimed to investigate the differences in perfusion pattern changes in right and left mesial temporal lobe epilepsy (mTLE). By using pulsed arterial spin labeling, 42 mTLE patients (22 left and 20 right mTLE) and 14 controls were surveyed. The results showed that cerebral blood flow decreased in the ipsilateral sides in both epilepsy subcohorts, with right mTLE showing significant differences in most regions of interest (ROIs), while left mTLE did not exhibit significant changes. Compared to controls, left mTLE displayed significant drops in cerebral blood flow in the left middle temporal and left intermediate posterior cerebral artery ROIs, as well as in the asymmetry index analysis in the parahippocampus, distal anterior cerebral artery, distal middle cerebral artery, and intermediate anterior cerebral artery. Cerebral blood flow hypoperfusion was observed in the left intermediate anterior cerebral artery, left middle temporal, right middle temporal, and left superior temporal in right mTLE patients compared to controls. Left mTLE also differed significantly from right mTLE in cerebral blood flow in the right distal middle cerebral artery ROI and the asymmetry index of the proximal middle cerebral artery.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shota Ishida, Makoto Isozaki, Yasuhiro Fujiwara, Naoyuki Takei, Masayuki Kanamoto, Hirohiko Kimura, Tetsuya Tsujikawa
Summary: Using simulation-based supervised DNNs can reduce the effects of Rician noise on ASL parameter estimation and compute unbiased CBF and ATT values. The study found that DNN outperforms conventional methods in terms of accuracy, precision, and noise immunity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Katja Neumann, Martin Schidlowski, Matthias Guenther, Tony Stoecker, Emrah Duezel
Summary: The study investigated the reliability and reproducibility of perfusion measures using an innovative Hadamard encoded pCASL sequence on healthy elderly individuals. The results demonstrated excellent reliability of CBF and ATT measures in different brain regions, with ATT appearing to be even more reliable than CBF. High intra-class correlation coefficients indicated substantial agreement of perfusion values acquired on two different MRI systems, suggesting potential improvements for future follow-up perfusion studies in aging and/or diseased brains.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dapeng Liu, Dan Zhu, Feng Xu, Farzad Sedaghat, Qin Qin
Summary: The purpose of this study was to develop velocity selective arterial spin labeling (VSASL) protocols for prostate blood flow (PBF) and prostate blood volume (PBV) mapping. Fourier-transform based velocity-selective inversion and saturation pulse trains were used to obtain blood flow and blood volume weighted perfusion signal in VSASL sequences. The study found that a low cutoff velocity of 0.25-0.50 cm/s was necessary for adequate perfusion signal in both PBF and PBV measurements in prostate.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Endocrinology & Metabolism
Dan Huang, Yunlu Guo, Xiaoyu Guan, Lijun Pan, Ziyu Zhu, Zeng'ai Chen, Rick M. Dijkhuizen, Marco Duering, Fang Yu, Johannes Boltze, Peiying Li
Summary: Cognitive impairment (CI) is a significant health concern in aging populations and is often associated with vascular cognitive impairment (VCI). Reduced cerebral blood flow (CBF) plays a critical role in the progression of VCI, and arterial spin labeling (ASL) is a non-invasive MRI technique that can accurately assess CBF. Recent advancements in ASL have improved its usability and led to an increased application in identifying high-risk VCI patients. ASL, when combined with other imaging modalities and biomarkers, shows great potential in early detection and prevention strategies for VCI.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Clinical Neurology
Alvaro Rojas-Villabona, Magdalena Sokolska, Thomas Solbach, Joan Grieve, Marilena Rega, Francisco Torrealdea, Francesca Benedetta Pizzini, Enrico De Vita, Yuriko Suzuki, Matthias J. P. Van Osch, Emma Biondetti, Karin Shmueli, David Atkinson, Mary Murphy, Ian Paddick, Xavier Golay, Neil Kitchen, Hans Rolf Jager
Summary: The study demonstrated the technical feasibility of using triple-MRA for visualization and delineation of brain AVMs for GKR planning, showing that it can achieve tighter and more precise delineation of AVM target volumes compared to traditional methods, potentially providing better outcomes for radiosurgery treatment.
BRITISH JOURNAL OF NEUROSURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaolin Wu, Stefanie Gurzing, Christiaan Schinkel, Merel Toussaint, Romana Perinajova, Pim van Ooij, Sasa Kenjeres
Summary: This study compared the hemodynamics of a patient-specific intracranial saccular aneurysm using in vivo 4D Flow MRI, in silico CFD, and in vitro Stereo-PIV and Tomo-PIV techniques. Results showed similar flow features and overall WSS distribution, but significant variations in absolute WSS values. Differences in spatial resolution were identified as a main contributor to discrepancies between modalities, cautioning against using absolute WSS values for quantitative risk analysis of aneurysm rupture.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Clinical Neurology
Eric James Mallack, Keith P. Van Haren, Anna Torrey, Stephanie van de Stadt, Marc Engelen, Gerald Raymond, Ali Fatemi, Florian S. Eichler
Summary: The study provides a detailed description of the timing of lesion formation, enhancement, and treatment among boys with presymptomatic CCALD, offering benchmarks for standardizing clinical care and designing future clinical trials.
Article
Clinical Neurology
Marc Engelen, Wouter J. C. Van Ballegoij, Eric James Mallack, Keith P. Van Haren, Wolfgang Kohler, Ettore Salsano, A. S. P. Van Trotsenburg, Fanny Mochel, Caroline Sevin, Molly O. Regelmann, Nicholas A. Tritos, Alyssa Halper, Robin H. Lachmann, James Davison, Gerald V. Raymond, Troy C. Lund, Paul J. Orchard, Joern-Sven Kuehl, Caroline A. Lindemans, Paul Caruso, Bela Rui Turk, Ann B. Moser, Frederic M. Vaz, Sacha Ferdinandusse, Stephan Kemp, Ali Fatemi, Florian S. Eichler, Irene C. Huffnagel
Summary: This study aims to develop best-practice recommendations for diagnosis, clinical surveillance, and treatment of ALD. Through a consensus-based modified Delphi approach, regular monitoring, HCT treatment, and international collaboration are identified as important factors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. L. Franklin, Megan Schuurmans, Martins Otikovs, Pim T. S. Borman, Matthias J. P. van Osch, Clemens Bos
Summary: This study evaluated the feasibility and robustness of using SPEN readout for pCASL imaging in the brain, and its resistance to susceptibility artifacts caused by aneurysm clips. The results showed that SPEN with Q greater than 75 can provide better resistance to field inhomogeneity compared to SE-EPI and GE-EPI, and the clip-induced artifact with SPEN was smaller.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
David G. J. Heesterbeek, Kirsten Koolstra, Matthias J. P. van Osch, Martin B. van Gijzen, Franciscus M. Vos, Martijn A. Nagtegaal
Summary: This study proposes a method for optimizing the MR fingerprinting (MRF) sequence by taking into account both the applied undersampling pattern and a realistic reference map. By optimizing the flip angle sequence, the undersampling artifacts can be significantly reduced. Numerical simulations and in vivo measurements show that the optimized sequence exhibits better robustness against undersampling artifacts.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Correction
Radiology, Nuclear Medicine & Medical Imaging
Qin Qin, David C. C. Alsop, Divya S. S. Bolar, Luis Hernandez-Garcia, James Meakin, Dapeng Liu, Krishna S. S. Nayak, Sophie Schmid, Matthias J. P. van Osch, Eric C. C. Wong, Joseph G. G. Woods, Greg Zaharchuk, Moss Y. Y. Zhao, Zungho Zun, Jia Guo
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Oncology
Krishnapriya Venugopal, Fatemeh Arzanforoosh, Danielle van Dorth, Marion Smits, Matthias J. P. van Osch, Juan A. A. Hernandez-Tamames, Esther A. H. Warnert, Dirk H. J. Poot
Summary: Characterizing tumor microvasculature is crucial for tumor assessment and treatment response studies. This study proposes a magnetic resonance vascular fingerprinting (MRVF) technique using hybrid echo planar imaging (HEPI) based on dynamic susceptibility contrast (DSC). The approach was tested in patients with gliomas, enabling the simultaneous estimation of vessel radius and relative cerebral blood volume. The results were consistent with those obtained using the vessel size imaging (VSI) technique, and MRVF showed robustness in noise estimation. DSC-HEPI-based MRVF allows for efficient characterization of glioma microvasculature and can be further improved for better understanding of tumor physiology.
Article
Endocrinology & Metabolism
L. Malin Overmars, Sanne Kuipers, Bram van Es, Jeroen de Bresser, Esther E. Bron, Imo E. Hoefer, Wouter W. Van Solinge, L. Jaap Kappelle, Matthias J. P. van Osch, Charlotte E. Teunissen, Geert Jan Biessels, Saskia Haitjema
Summary: The biological processes causing decreased cerebral blood flow in cardiovascular disease patients are not well understood. Identifying protein clusters associated with lower cerebral blood flow may provide insight into these underlying processes.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yiming Dong, Kirsten Koolstra, Ziyu Li, Malte Riedel, Matthias J. P. van Osch, Peter Boernert
Summary: The proposed algorithm effectively eliminates shot-to-shot phase variations and separates water/fat images, providing a promising solution for future DWI on different anatomies.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Renske Merton, Daan Bosshardt, Gustav J. Strijkers, Aart J. Nederveen, Eric M. Schrauben, Pim van Ooij
Summary: This study investigates the reproducibility of obtaining 3D displacement and diameter maps using accelerated 3D cine MRI at 3 T. The results show that the method allows for reproducible quantification of systolic-diastolic mean aortic displacement within acceptable limits.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Biophysics
Chih-Hsien Tseng, Jaap Jaspers, Alejandra Mendez Romero, Piotr Wielopolski, Marion Smits, Matthias J. P. van Osch, Frans Vos
Summary: The arterial input function (AIF) is crucial for estimating perfusion properties from dynamic susceptibility contrast (DSC) MRI. Measuring the AIF in absolute contrast-agent concentrations is challenging, but deriving the AIF from separately acquired dynamic contrast enhanced (DCE) MRI data is a potential solution. This study compared the AIFs derived from DCE and DSC MRI data and found that the DCE-based AIFs provided more stable and realistic measurements of perfusion coefficients.
NMR IN BIOMEDICINE
(2023)
Article
Oncology
Barbara Schmitz-Abecassis, Linda Dirven, Janey Jiang, Jasmin A. Keller, Robert J. Croese, Danielle van Dorth, Rashid Ghaznawi, Ilse M. J. Kant, Martin J. B. Taphoorn, Matthias J. P. van Osch, Johan A. F. Koekkoek, Jeroen de Bresser
Summary: This study establishes different MRI phenotypes of glioblastomas at 3 months after radiotherapy through combined analysis of structural and perfusion tumor characteristics, and finds that one of the phenotypes is significantly associated with increased mortality risk.
NEURO-ONCOLOGY ADVANCES
(2023)
Article
Clinical Neurology
L. P. Onkenhout, Tine Arts, D. Ferro, E. A. Oudeman, M. J. P. van Osch, J. J. M. Zwanenburg, J. Hendrikse, L. J. Kappelle, GJ. Biessels
Summary: The study suggests that carotid occlusive disease may be associated with abnormal cerebral perforating artery flow and that this relates to the burden of small vessel disease lesions in these patients.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2022)