Article
Neurosciences
Sisi Li, Yishi Wang, Zhangxuan Hu, Li Guan, Yong Hai, Hanwen Zhang, Le He, Wen Jiang, Hua Guo
Summary: This study successfully achieved high-fidelity spinal cord DTI using PSF-EPI technique, demonstrating its clinical potential. The technique effectively reduced distortion and improved consistency with anatomical references, especially for patients with metallic implants.
Article
Clinical Neurology
Fengzhao Zhu, Yulong Wang, Xiangchuang Kong, Yuan Liu, Lian Zeng, Xirui Jing, Sheng Yao, Kaifang Chen, Lian Yang, Xiaodong Guo
Summary: The combination of conventional MRI with DTI-DTT is a valid diagnostic approach for acute traumatic cervical SCI. Lower intramedullary lesion length and intramedullary hemorrhage length, and higher fractional anisotropy value and connection rates of fiber tractography are linked to better neurological outcomes.
EUROPEAN SPINE JOURNAL
(2022)
Article
Veterinary Sciences
Kiyotaka Arai, Takamasa Itoi, Natsuki Akashi, Masahiro Miyabe, Keisuke Sugimoto, Akira Matsuda, Noritaka Maeta, Teppei Kanda, Kenji Kutara
Summary: This study performed diffusion tensor imaging (DTI) scans on adult Beagle dogs and analyzed DTI parameters in different regions. The results showed that DTI parameters significantly decreased in the caudal direction, but were not significantly correlated with vertebral levels. These findings contribute to the development of a clinical reference for evaluating spinal cord in dogs using DTI parameters.
VETERINARY SCIENCES
(2023)
Article
Medicine, General & Internal
Nagendra B. Gutti, Jayantee Kalita, Prakash C. Pandey
Summary: This case report highlights a patient with paroxysmal hemidystonia and its association with spinal pathology. The patient's symptoms improved with carbamazepine, suggesting a potential connection between spinal lesions and paroxysmal dystonia.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Clinical Neurology
Makoto Kobayashi
Summary: Background Magnetic resonance imaging (MRI) plays a crucial role in diagnosing spinal cord infarction (SCI) and neuromyelitis optica spectrum disorder (NMOSD), but it is difficult to differentiate the findings between the two. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) maps can help distinguish SCI from NMOSD. Therefore, the time from symptom onset, imaging sequence, and imaging plane should be considered in the diagnosis.
Article
Neurosciences
Kurt G. Schilling, Shreyas Fadnavis, Joshua Batson, Mereze Visagie, Anna J. E. Combes, Samantha By, Colin D. McKnight, Francesca Bagnato, Eleftherios Garyfallidis, Bennett A. Landman, Seth A. Smith, Kristin P. O'Grady
Summary: This study evaluates several denoising approaches for quantitative diffusion MRI of the spinal cord. The findings show that all methods improve signal-to-noise ratio and lesion visibility, and MPPCA and Patch2Self methods excel at improving image quality and intra-cord contrast. These denoising approaches have the potential to facilitate reliable diffusion observations and measurements in the spinal cord.
Article
Clinical Neurology
Jan Valosek, Rene Labounek, Tomas Horak, Magda Horakova, Petr Bednarik, Milos Kerkovsky, Jan Kocica, Tomas Rohan, Christophe Lenglet, Julien Cohen-Adad, Petr Hlustik, Eva Vlckova, Zdenek Kadanka, Josef Bednarik, Alena Svatkova
Summary: The study found diffusion abnormalities in the gray matter, dorsal and lateral tracts in chronic degenerative spinal cord compression, with more profound alterations in DCM than NMDC patients. Diffusion metrics were affected in the C3-6 area and above the compression level at C3, with more profound rostral deficits in DCM. Alterations in lateral motor and dorsal sensory tracts correlated with motor and sensory evoked potentials, while electromyography outcomes corresponded with gray matter microstructure. DCM disability corresponded with microstructure alteration in lateral columns.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Xie, Yan Zhang, Yihao Yao, Dong Liu, Bo Chen, Wenzhen Zhu
Summary: The characteristics of optic nerve impairment in neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) patients were assessed using fractional anisotropy (FA). The study found that FA values were significantly decreased in the optic nerves of NMOSD patients, especially in the posterior segment. FA values in the anterior and middle segments of the optic nerve were also decreased in MS patients. Significant differences in FA values were observed in the posterior segment between NMOSD and MS patients. The combination of FA and signal intensity ratio (SIR) showed good diagnostic performance in distinguishing between NMOSD and MS.
EUROPEAN RADIOLOGY
(2022)
Article
Acoustics
R. Corroenne, D. Grevent, H. Mahallati, G. Gauchard, L. Bussieres, Y. Ville, L. J. Salomon
Summary: This study aimed to evaluate the feasibility of DTI of the spinal cord in utero and examine gestational-age-related changes in DTI parameters. The results showed that DTI of the spinal cord is feasible in normal fetuses and there is a significant GA-related change in FA in the fetal spinal cord during pregnancy.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Polymer Science
Axayacatl Morales-Guadarrama, Hermelinda Salgado-Ceballos, Israel Grijalva, Juan Morales-Corona, Braulio Hernandez-Godinez, Alejandra Ibanez-Contreras, Camilo Rios, Araceli Diaz-Ruiz, Guillermo Jesus Cruz, Maria Guadalupe Olayo, Stephanie Sanchez-Torres, Rodrigo Mondragon-Lozano, Laura Alvarez-Mejia, Omar Fabela-Sanchez, Roberto Olayo
Summary: Spinal cord injury (SCI) causes damage to nervous tissue and lacks effective therapeutic strategies. Polymers synthesized by pyrrole-derived plasma have shown to promote neuronal growth in cell cultures and enhance motor function recovery in acute SCI models. This study uses diffusion tensor imaging (DTI) to evaluate SCI evolution in nonhuman primates, with results consistent with histology and motor function.
Article
Clinical Neurology
Rosa Cortese, Ferran Prados Carrasco, Carmen Tur, Alessia Bianchi, Wallace Brownlee, Floriana De Angelis, Isabel de la Paz, Francesco Grussu, Lukas Haider, Anu Jacob, Baris Kanber, Lise Magnollay, Richard S. Nicholas, Anand Trip, Marios Yiannakas, Ahmed T. Toosy, Yael Hacohen, Frederik Barkhof, Olga Ciccarelli
Summary: This study investigated whether imaging characteristics could differentiate between relapsing-remitting multiple sclerosis (RRMS), aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). The results showed that the proportion of lesions with the central vein sign (CVS) was the most accurate measure to differentiate RRMS from AQP4-NMOSD, while white matter lesions were the most accurate measure to discriminate RRMS from MOGAD.
Article
Neuroimaging
Anna J. E. Combes, Baxter P. Rogers, Kurt G. Schilling, Richard D. Lawless, Mereze Visagie, Delaney Houston, Logan Prock, Shekinah Malone, Sanjana Satish, Atlee A. Witt, Colin D. McKnight, Francesca Bagnato, John C. Gore, Seth A. Smith
Summary: Focal lesions can impact the functional connectivity of the ventral and dorsal networks in the cervical spinal cord of individuals with RRMS. This study examines the relationship between alterations in connectivity and damage in normal-appearing tissue. The results suggest that increased connectivity in response to structural damage may play a compensatory role in preserving sensory function in RRMS.
NEUROIMAGE-CLINICAL
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica and its spectrum is a relapsing demyelinating disorder of the central nervous system, encompassing six syndromes and associated with aquaporin-4 autoantibodies. Effective treatment is able to prevent relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica, previously known as Devic's disease, is a relapsing demyelinating disorder of the central nervous system that encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment is crucial in preventing relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Francisco J. Navas-Sanchez, Luis Marcos-Vidal, Daniel Martin de Blas, Alberto Fernandez-Pena, Yasser Aleman-Gomez, Juan A. Guzman-de-Villoria, Julia Romero, Irene Catalina, Laura Lillo, Jose L. Munoz-Blanco, Andres Ordonez-Ugalde, Beatriz Quintans, Maria-Jesus Sobrido, Susanna Carmona, Francisco Grandas, Manuel Desco
Summary: This study assessed the spinal cord characteristics of SPG4 patients using diffusion tensor imaging (DTI) and structural analysis. The results showed that SPG4 patients had reduced cross-sectional area and anteroposterior flattening in the spinal cord, as well as changes in diffusion characteristics. These findings were correlated with the severity of motor disability.
JOURNAL OF NEUROLOGY
(2022)
Article
Nursing
Li Tang, Andy H. Lee, Colin W. Binns, Yer Van Hui, Kelvin K. W. Yau
Article
Emergency Medicine
Mina Cheng, Moon-Tong Cheung, Kin-Yan Lee, Kin-Bong Lee, Susan-C H. Chan, Amy-C Y. Wu, Yu-Fat Chow, Annice-M L. Chang, Hiu-Fai Ho, Kelvin-K W. Yau
EMERGENCY MEDICINE JOURNAL
(2015)
Article
Surgery
K. V. Chan, C. K. O. Chan, K. W. Yau, M. T. Cheung
Article
Neurosciences
Henry Ka-Fung Mak, Wenshu Qian, Kwok Sing Ng, Queenie Chan, You-Qiang Song, Leung Wing Chu, Kelvin Kai-Wing Yau
JOURNAL OF ALZHEIMERS DISEASE
(2014)
Article
Endocrinology & Metabolism
Henry Ka-Fung Mak, Shui-Wun Lai, Wenshu Qian, Stanley Xu, Elizabeth Tong, May Lee Vance, Edward Oldfield, John Jane, Jason Sheehan, Kelvin K. W. Yau, Max Wintermark
Article
Biochemical Research Methods
Moritz Zaiss, Kai Herz, Anagha Deshmane, Mina Kim, Xavier Golay, Tobias Lindig, Benjamin Bender, Ulrike Ernemann, Klaus Scheffler
JOURNAL OF MAGNETIC RESONANCE
(2019)
Article
Biochemical Research Methods
Aaron Kujawa, Mina Kim, Eleni Demetriou, Annasofia Anemone, Dario Livio Longo, Moritz Zaiss, Xavier Golay
JOURNAL OF MAGNETIC RESONANCE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vincent Stephen Evans, Francisco Torrealdea, Marilena Rega, Mrishta Brizmohun Appayya, Arash Latifoltojar, Harbir Sidhu, Mina Kim, Aaron Kujawa, Shonit Punwani, Xavier Golay, David Atkinson
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mina Kim, Francisco Torrealdea, Sola Adeleke, Marilena Rega, Vincent Evans, Teresita Beeston, Katerina Soteriou, Stefanie Thust, Aaron Kujawa, Sachi Okuchi, Elizabeth Isaac, Wivijin Piga, Jonathan R. Lambert, Asim Afaq, Eleni Demetriou, Pratik Choudhary, King Kenneth Cheung, Sarita Naik, David Atkinson, Shonit Punwani, Xavier Golay
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mina Kim, Aaron Kujawa, Marco Battiston, Eleni Demetriou, Torben Schneider, Sara Collorone, Carmen Tur, Vincent Evans, Sachi Okuchi, David Atkinson, Claudia A. M. Gandini Wheeler-Kingshott, Xavier Golay
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhongping Zhang, Dhanashree Vernekar, Wenshu Qian, Mina Kim
Summary: The study demonstrates that incorporating a Rician denoising NLM filter with the CLLS approach significantly enhances the signal-to-noise ratio and reduces estimation errors of DT- and KT-derived metrics in various anatomical regions of the human brain and spinal cord. This combined method provides reliable metric estimation with adequate SNR levels.
BMC MEDICAL IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Bender, Kai Herz, Anagha Deshmane, Vivien Richter, Ghazaleh Tabatabai, Jens Schittenhelm, Marco Skardelly, Klaus Scheffler, Ulrike Ernemann, Mina Kim, Xavier Golay, Moritz Zaiss, Tobias Lindig
Summary: The clinical relevance of dynamic glucose enhanced (DGE) chemical exchange saturation transfer (CEST) imaging has typically been demonstrated at ultra-high field (UHF), but results of a cohort study at clinical field strength are presented here. DGE imaging showed that in high-grade gliomas with blood-brain barrier (BBB) leakage, d-glucose uptake could be detected in specific regions, while glioma patients without BBB leakage showed no detectable DGE effect within the tumor. This suggests a correlation between BBB leakage and DGE signal, regardless of tumor grade.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mina Kim, Afroditi Eleftheriou, Luca Ravotto, Bruno Weber, Michal Rivlin, Gil Navon, Martina Capozza, Annasofia Anemone, Dario Livio Longo, Silvio Aime, Moritz Zaiss, Kai Herz, Anagha Deshmane, Tobias Lindig, Benjamin Bender, Xavier Golay
Summary: This article discusses the importance of advanced medical imaging technology in the early detection of cancer, and the sensitivity of dynamic glucose-enhanced MRI in cancer detection. The GLINT consortium is an important international collaboration project aimed at translating this technology into clinical practice.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Ergonomics
Guangnan Zhang, Kelvin K. W. Yau, Xun Zhang, Yanyan Li
ACCIDENT ANALYSIS AND PREVENTION
(2016)
Review
Oncology
Sachi Okuchi, Ahmed Hammam, Xavier Golay, Mina Kim, Stefanie Thust
RADIOLOGY-IMAGING CANCER
(2020)