期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 34, 期 1, 页码 88-94出版社
WILEY
DOI: 10.1002/jmri.22630
关键词
MR Imaging; liver; hepatocellular carcinoma; gadoxetic acid
资金
- Grants-in-Aid for Scientific Research [23591983, 23390195] Funding Source: KAKEN
Purpose: To elucidate the natural history of hypovascular nodules that appear hypointense on hepatocyte-phase gadoxetic acid-enhanced MR images by focusing on hypervascularization over time. Materials and Methods: In this study, 135 hypovascular nodules revealing no gadoxetic acid uptake in 53 patients were examined. All nodules were retrospectively examined using serial follow-up computed tomography (CT) and MRI examinations until hypervascularity was observed on arterial-phase dynamic CT or gadoxetic acid-enhanced MR images, or on CT during hepatic arteriography. Logistic regression analysis was used to investigate the association between hypervascularization and MR findings Including a presence of fat assessed by a signal drop on opposed-phase T1-weighted images. Results: Of the 135 nodules, 16 underwent hypervascularization. The size of the nodules and the presence of fat In the nodules were independent indicators of hypervascularization. The 1-year cumulative risk of hypervascularization was 15.6%. This risk was significantly increased in the case of nodules >10 mm (37.6%, P < 0.01) and fat-containing nodules (26.5%, P < 0.01). Conclusion: Hypovascular nodules that appear hypointense on hepatocyte-phase gadoxetic acid-enhanced MR images may progress to conventional hypervascular hepatocellular carcinoma. Nodules more than 10 mm in diameter and containing fat are at high risk for developing hypervascularization.
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