Article
Multidisciplinary Sciences
Jiaqi Liu, Shiyun Li, Huashan Lin, Peiei Pang, Puying Luo, Bing Fan, Juhong Yu
Summary: The aim of this study was to develop a predictive model for the classification of benign and malignant endometrial lesions and evaluate its potential clinical applicability. A radiomics prediction model was established from 15 selected features and showed high discriminative ability in both the training and test cohorts. The radiomics nomogram also demonstrated good performance in discrimination and the decision curve analysis showed its clinical usefulness.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Chengyue Wu, Angela M. Jarrett, Zijian Zhou, Nabil Elshafeey, Beatriz E. Adrada, Rosalind P. Candelaria, Rania M. M. Mohamed, Medine Boge, Lei Huo, Jason B. White, Debu Tripathy, Vicente Valero, Jennifer K. Litton, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov
Summary: This study successfully predicts the response of TNBC to neoadjuvant systemic therapy using MRI data and mathematical modeling, providing highly accurate predictions of therapeutic efficacy.
Article
Clinical Neurology
Samuel Shribman, Martina Bocchetta, Carole H. Sudre, Julio Acosta-Cabronero, Maggie Burrows, Paul Cook, David L. Thomas, Godfrey T. Gillett, Emmanuel A. Tsochatzis, Oliver Bandmann, Jonathan D. Rohrer, Thomas T. Warner
Summary: Wilson's disease is a genetic disorder that affects copper metabolism and can lead to neurological and hepatic symptoms. This study used neuroimaging techniques to analyze brain abnormalities in patients with Wilson's disease and found differences between those with neurological and hepatic presentations. The severity of neurological deficits was correlated with reductions in grey matter volume in certain brain regions. Additionally, the study identified associations between neurological severity and changes in white matter integrity and iron deposition. These findings provide insights into the disease mechanisms and suggest potential biomarkers for prognosis and monitoring.
Article
Biology
Ga-Eun Park, Bong-Joo Kang, Sung-hun Kim, Na-Young Jung
Summary: In this study, the use of diffusion-weighted imaging maximum-intensity projections (DWI MIPs) as a supportive tool for young patients with marked background parenchymal enhancement (BPE) on contrast-enhanced MRI (CE-MRI) was investigated. The results showed that DWI MIPs had higher accuracy in lesion detection and provided valuable information for predicting clinical parameters of patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zyad M. Almutlaq, Daniel J. Wilson, Sarah E. Bacon, Nisha Sharma, Samuel Stephens, Tatendashe Dondo, David L. Buckley
Summary: This study aimed to investigate the value of diffusion coefficients derived from different models in predicting early response to neoadjuvant chemotherapy in patients with primary breast cancer. The results showed that tumor volume had reasonable performance in predicting response, while diffusion coefficients derived from the monoexponential, stretched-exponential, and intravoxel incoherent motion models did not accurately predict pathological response. However, certain derived parameters (such as alpha from the stretched-exponential model, and f and f x D-p from the intravoxel incoherent motion model) were able to predict the degree of response in breast cancer patients after one cycle of neoadjuvant chemotherapy.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Manato Yasuda, Atsuhiko Sugiyama, Hideharu Hokkoku, Tomoki Suichi, Kimiko Ito, Katsuya Satoh, Tetsuyuki Kitamoto, Satoshi Kuwabara
Summary: This study highlights the potential of using DWI abnormalities on preclinical brain MRI scans as highly sensitive diagnostic markers for presymptomatic sCJD.
Article
Oncology
Qi Liu, Jinggang Zhang, Man Jiang, Yue Zhang, Tongbing Chen, Jilei Zhang, Bei Li, Jie Chen, Wei Xing
Summary: In assessing the histopathological features of PDAC, the D and f values derived from the IVIM model showed higher sensitivity and diagnostic performance compared to the conventional DWI model. A significant negative correlation was found between D values and fibrosis, while a significant positive correlation was observed between f values and fibrosis. IVIM-DWI may serve as an imaging biomarker for predicting the fibrosis grade of PDAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ricardo Donners, Raphael Shih Zhu Yiin, Matthew Blackledge, Dow-Mu Koh
Summary: This study evaluated the ADC histogram parameters of lymph nodes in healthy volunteers and compared the differences in ADC values between different anatomical regions. The results showed significantly higher ADC values in intrathoracic, portal, and retroperitoneal nodes.
Article
Clinical Neurology
Justin K. Zhang, Dinal Jayasekera, Chunyu Song, Jacob K. Greenberg, Saad Javeed, Christopher F. Dibble, Jacob Blum, Peng Sun, Sheng-Kwei Song, Wilson Z. Ray
Summary: This study evaluated the utility of diffusion basis spectrum imaging (DBSI) in cervical spondylotic myelopathy (CSM) and found that DBSI can serve as a biomarker of CSM disease severity. The results showed that DBSI provides detailed data on white matter tract integrity and offers novel insights into the pathology of CSM.
Article
Neurosciences
Davood Karimi, Lana Vasung, Camilo Jaimes, Fedel Machado-Rivas, Simon K. Warfield, Ali Gholipour
Summary: This study proposed a data-driven method to improve the accuracy and robustness of white matter fiber orientation distribution function (fODF) estimation, demonstrating effectiveness through training with simulated and real data. In phantom and real data experiments, the method showed higher accuracy compared to other competing methods, particularly in under sampled diffusion measurements. Additionally, expert ratings indicated significantly better reconstruction of various brain tracts using the proposed method.
Article
Veterinary Sciences
Elizabeth Boudreau, Sharon C. Kerwin, Emily B. DuPont, Jonathan M. Levine, John F. Griffin
Summary: This study describes the diffusion-weighted MRI measurements of 22 cases of spontaneous canine cerebrovascular accident (CVA). The results show that the median ADC values in normal control tissues and CVAs were less than 1.0x10(-3) mm(2)/s. There was a good correlation between absolute and relative ADC values in CVAs. Some lesions exhibited reduced absolute ADC values but relatively unchanged relative ADC values compared to matched normal contralateral tissue. CVAs with large hemorrhagic components did not show restricted diffusion.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Oncology
S. Hafeez, M. Koh, K. Jones, A. El Ghzal, J. D'Arcy, P. Kumar, V Khoo, S. Lalondrelle, F. McDonald, A. Thompson, E. Scurr, A. Sohaib, R. Huddart
Summary: The role of diffusion-weighted magnetic resonance imaging (DWI) and apparent diffusion coefficient (ADC) analysis in assessing bladder radiotherapy response was investigated in this study. The results showed that quantitative DWI analysis can successfully provide non-invasive assessment of bladder radiotherapy response. Further multicentre validation and prospective testing are needed to determine its application in treatment decision-making.
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Petralia, Fabio Zugni, Paul E. Summers, Alberto Colombo, Paola Pricolo, Luigi Grazioli, Stefano Colagrande, Andrea Giovagnoni, Anwar R. Padhani
Summary: WB-MRI is recommended for cancer screening in individuals with cancer predisposition syndromes, as well as in asymptomatic subjects from the general population. The review focuses on analyzing acquisition protocols and synthesizing current recommendations regarding the use of WB-MRI for cancer screening.
Article
Oncology
Yan Bai, Taiyuan Liu, Lijuan Chen, Haiyan Gao, Wei Wei, Ge Zhang, Lifu Wang, Lingfei Kong, Siyun Liu, Huan Liu, Neil Roberts, Meiyun Wang
Summary: Different DWI metrics within different b-value ranges have different efficacies as surrogate indicators for molecular expression or microstructural complexity in gliomas. High-grade gliomas show lower ADC(st) and ADC(slow) and higher ADC(uh) and K-app, with significant correlations and differences at the tumor center.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Jonathan D. Santoro, Peter K. Moon, Michelle Han, Emily S. McKenna, Elizabeth Tong, Sarah J. MacEachern, Nils D. Forkert, Kristen W. Yeom
Summary: Individuals with medically refractory migraine headache show significant changes in apparent diffusion coefficient in multiple brain structures, suggesting structural connectivity issues may predispose some patients to more medically refractory pain disorders such as migraine headache. Volumetric differences were not observed between the two groups.
FRONTIERS IN NEUROLOGY
(2022)
Review
Urology & Nephrology
Baris Turkbey, Andrew B. Rosenkrantz, Masoom A. Haider, Anwar R. Padhani, Geert Villeirs, Katarzyna J. Macura, Clare M. Tempany, Peter L. Choyke, Francois Cornud, Daniel J. Margolis, Harriet C. Thoeny, Sadhna Verma, Jelle Barentsz, Jeffrey C. Weinreb
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastiano Barbieri, Oliver J. Gurney-Champion, Remy Klaassen, Harriet C. Thoeny
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anwar R. Padhani, Jelle Barentsz, Geert Villeirs, Andrew B. Rosenkrantz, Daniel J. Margolis, Bares Turkbey, Harriet C. Thoeny, Francois Cornud, Masoom A. Haider, Katarzyna F. Macura, Clare M. Tempany, Sadhna Verma, Jeffery C. Weinreb
Review
Radiology, Nuclear Medicine & Medical Imaging
Octavia Bane, Iosif A. Mendichovszky, Bastien Milani, Ilona A. Dekkers, Jean-Francois Deux, Per Eckerbom, Nicolas Grenier, Michael E. Hall, Tsutomu Inoue, Christoffer Laustsen, Lilach O. Lerman, Chunlei Liu, Glen Morrell, Michael Pedersen, Menno Pruijm, Elizabeth A. Sadowski, Erdmann Seeliger, Kanishka Sharma, Harriet Thoeny, Peter Vermathen, Zhen J. Wang, Zbigniew Serafin, Jeff L. Zhang, Susan T. Francis, Steven Sourbron, Andreas Pohlmann, Sean B. Fain, Pottumarthi V. Prasad
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Ljimani, Anna Caroli, Christoffer Laustsen, Susan Francis, Iosif Alexandru Mendichovszky, Octavia Bane, Fabio Nery, Kanishka Sharma, Andreas Pohlmann, Ilona A. Dekkers, Jean-Paul Vallee, Katja Derlin, Mike Notohamiprodjo, Ruth P. Lim, Stefano Palmucci, Suraj D. Serai, Joao Periquito, Zhen Jane Wang, Martijn Froeling, Harriet C. Thoeny, Pottumarthi Prasad, Moritz Schneider, Thoralf Niendorf, Pim Pullens, Steven Sourbron, Eric E. Sigmund
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2020)
Article
Clinical Neurology
Elisabeth Sartoretti, Thomas Sartoretti, Michael Wyss, Anton Becker, Arpad Schwenk, Luuk van Smoorenburg, Arash Najafi, Christoph Binkert, Harriet C. Thoeny, Jinyuan Zhou, Shanshan Jiang, Nicole Graf, David Czell, Sabine Sartoretti-Schefer, Carolin Reischauer
FRONTIERS IN NEUROLOGY
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sonaz Malekzadeh, Lucien Widmer, Faezeh Salahshour, Bernhard Egger, Maxime Ronot, Harriet C. Thoeny
Summary: Hepatic infections are common in clinical practice and imaging plays a crucial role in confirming the diagnosis, assessing disease extension and complications, evaluating treatment response, and making differential diagnoses. Familiarity with the radiological features of hepatic infections can aid in suggesting the correct diagnosis and determining appropriate treatment.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fabian H. J. Elsholtz, Patrick Asbach, Matthias Haas, Minerva Becker, Regina G. H. Beets-Tan, Harriet C. Thoeny, Anwar R. Padhani, Bernd Hamm
Summary: Node-RADS is a new imaging assessment system that systematically classifies the degree of suspicion of lymph node involvement based on established imaging findings. It improves communication with referring physicians and promotes consistency in reporting for primary staging and response assessment.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carolin Reischauer, Timmy Cancelli, Sonaz Malekzadeh, Johannes M. Froehlich, Harriet C. Thoeny
Summary: The study found that enema preparation is superior to catheter preparation for prostate DWI imaging, significantly improving image quality by reducing susceptibility-related artifacts and image distortions.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Marc A. Furrer, Nathan Papa, Sandro Luetolf, Beat Roth, Marcus Cumberbatch, Mihai Dorin Vartolomei, Benjamin C. Thomas, Harriet C. Thoeny, Roland Seiler, George N. Thalmann, Bernhard Kiss
Summary: Re-staging after two cycles of neoadjuvant chemotherapy provides limited additional information and rarely affects patient management, while re-staging after completion of NAC by CT is a strong predictor of overall survival.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
David A. Bluemke
Review
Medicine, General & Internal
Thomas De Perrot, Christine Sadjo Zoua, Carl G. Glessgen, Diomidis Botsikas, Lena Berchtold, Rares Salomir, Sophie De Seigneux, Harriet C. Thoeny, Jean-Paul Vallee
Summary: Diffusion weighted imaging (DWI) is an important functional parameter in MRI that can assess tissue water mobility. It has a wide range of applications in genitourinary imaging, helping with the diagnosis and differentiation of various diseases, particularly in decision making for female pelvis and prostate cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Eva Comperat, Mahul B. Amin, Richard Cathomas, Ananya Choudhury, Maria De Santis, Ashish Kamat, Arnulf Stenzl, Harriet C. Thoeny, Johannes Alfred Witjes
Summary: This Seminar presents the current best practice for the diagnosis and management of bladder cancer, including challenges in pathology, advances in personalised medicine, and novel imaging approaches. It discusses the role of radiotherapy, surgical management, treatment of metastatic bladder cancer, and latest developments in systemic therapy.
Review
Oncology
Armando Stabile, Elio Mazzone, Giuseppe O. Cirulli, Francesco De Cobelli, Jeremy Grummet, Harriet C. Thoeny, Mark Emberton, Morgan Pokorny, Peter A. Pinto, Samir S. Taneja
Summary: The study systematically reviewed the relationship between pre-treatment mpMRI and oncological outcomes after primary treatment for PCa. PI-RADS scores were found to predict biochemical recurrence, while tumor volume at mpMRI was not significantly associated with recurrence. Limited data on disease progression and PCa-specific mortality were reported. Substantial heterogeneity among studies was noted.
EUROPEAN UROLOGY ONCOLOGY
(2021)
Proceedings Paper
Computer Science, Artificial Intelligence
Giuseppe Cuccu, Johan Jobin, Julien Clement, Akansha Bhardwaj, Carolin Reischauer, Harriet Thony, Philippe Cudre-Mauroux
2020 IEEE INTERNATIONAL CONFERENCE ON BIG DATA (BIG DATA)
(2020)