Review
Radiology, Nuclear Medicine & Medical Imaging
Anjan Bhattarai, Gary F. Egan, Paul Talman, Phyllis Chua, Zhaolin Chen
Summary: This review provides an overview of MRI techniques used to investigate iron dysregulation in ALS, highlighting their potential uses and limitations in disease diagnosis and prognosis. It recommends further longitudinal studies to validate the efficacy of these techniques and concludes that quantitative iron assessment using QSM in MRI holds great potential as a sensitive diagnostic and prognostic marker in ALS. Furthermore, combining multimodal neuroimaging markers with iron imaging may offer improved sensitivity in ALS diagnosis and prognosis, contributing significantly to clinical care and treatment trials.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Helen Bachmann, Melissa Cambron, Jan W. Casselman, Veroniek Van Driessche, Eline Van Haute, Liesbeth Van Hijfte, Tim Kelderman, Dimitri Hemelsoet, Guy Laureys
Summary: In this study, the occurrence of occult hemorrhagic cerebral lesions after alemtuzumab treatment was investigated in RRMS patients, with no significant findings. There was no association found between alemtuzumab treatment and arterial hypertension, intracerebral hemorrhage, or occult microbleeds in the patient population studied.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Koy Chong Ng Kee Kwong, Daisy Mollison, Rozanna Meijboom, Elizabeth N. York, Agniete Kampaite, Sarah-Jane Martin, David P. J. Hunt, Michael J. Thrippleton, Siddharthan Chandran, Adam D. Waldman
Summary: Rim lesions, characterized by a paramagnetic rim on susceptibility-based MRI, were detected in 27% of early relapsing-remitting MS patients in this multicenter study. The difference in longitudinal volume change between rim lesions and non-rim lesions is still unclear at this stage. Further validation and standardization in defining rim lesions as a biomarker of chronic inflammation are needed for potential translation into routine MS clinical practice.
Article
Clinical Neurology
Loredana Storelli, Elisabetta Pagani, Alessandro Meani, Paolo Preziosa, Massimo Filippi, Maria A. Rocca
Summary: The study suggests that advanced diffusion-weighted imaging techniques can accurately detect white matter atrophy in patients with multiple sclerosis, providing more specific information than traditional methods that only measure volume and diffusion. Additionally, measures such as voxel-wise fiber-bundle cross-section and intra-cellular volume obtained at baseline are better predictors of clinical disability and cognitive impairment.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Masoud Rabbani, Vahid Shaygannejad, Mahshid Bahrami, Sajad Badiei
Summary: The study aimed to compare susceptibility-weighted imaging (SWI) with conventional MRI methods in multiple sclerosis (MS) plaque assessment, finding similar efficiency between SWI and conventional MRI sequences for plaque evaluation in MS patients. There was no significant difference in plaque number and volume between different imaging modalities, and a high correlation was observed between SWI and T2W/FLAIR conventional imaging techniques in estimating plaque characteristics.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Review
Clinical Neurology
Massimo Filippi, Paolo Preziosa, Douglas L. Arnold, Frederik Barkhof, Daniel M. Harrison, Pietro Maggi, Caterina Mainero, Xavier Montalban, Elia Sechi, Brian G. Weinshenker, Maria A. Rocca
Summary: The use of MRI in the diagnosis of MS has evolved considerably, with the introduction of the 2017 McDonald criteria and new MRI markers. Artificial intelligence tools may complement human assessment in improving diagnosis and patient classification.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
E. Mark Haacke, Yulin Ge, Sean K. Sethi, Sagar Buch, Paolo Zamboni
Summary: The etiology of multiple sclerosis is believed to be autoimmune, but evidence suggests disrupted vasculature and flow play a significant role. Abnormal flow in the medullary vein system is implicated, with history dating back to the nineteenth century. Vascular effects in MS lesions involve endothelial damage, venous collagenosis, and ultimately lead to inflammatory and demyelinating events.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Christopher Hollen, Lee E. Neilson, Ramon F. Barajas, Ian Greenhouse, Rebecca I. Spain
Summary: Conventional MRI is important for evaluating patients with multiple sclerosis, but its role in detecting the underlying pathophysiology of neurodegeneration is limited. Biomarkers that identify processes underlying neurodegeneration before irreversible damage occurs are needed. Oxidative stress is believed to play a major role in the pathogenesis of multiple neurodegenerative diseases, including multiple sclerosis. Non-invasive imaging techniques offer real-time assessment of oxidative stress within the brain, which is an area of unrealized potential.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giuseppe Pontillo, Maria Petracca, Serena Monti, Mario Quarantelli, Roberta Lanzillo, Teresa Costabile, Antonio Carotenuto, Fabio Tortora, Andrea Elefante, Vincenzo Brescia Morra, Arturo Brunetti, Giuseppe Palma, Sirio Cocozza
Summary: In this study, we found that patients with multiple sclerosis (MS) have widespread R1 changes, brain atrophy, and limited changes in tissue chi. Additionally, the atrophy and chi changes are related to global and motor disability, while the R1 changes are meaningful correlates of cognition.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Kelly A. Clark, Abby R. Manning, Luyun Chen, Fang Liu, Quy Cao, Amit Bar-Or, Russell T. Shinohara, Elizabeth Sweeney, Matthew K. Schindler
Summary: This study aimed to identify early MRI features of new multiple sclerosis (MS) lesions that would develop into paramagnetic rim lesions (PRLs) associated with progressive tissue injury in MS. Contrast-enhancing lesions in MS patients were imaged at 7 T within 4 weeks of observation and 3 and 6 months later. The study found that certain characteristics of early lesions were predictive of subsequent PRL status.
ANNALS OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rezvan Afkandeh, Maziar Irannejad, Iraj Abedi, Masoud Rabbani
Summary: This study proposes a Bayesian approach to automatically detect active and inactive multiple sclerosis (MS) plaques in SWI images. The results show that the method has a high accuracy rate of 91% and a sensitivity rate of 76% in identifying plaque types and areas. The analysis reveals an 80% agreement between expert diagnoses and Bayesian inferences.
Article
Clinical Neurology
Margareta A. Clarke, Rachael Cheek, Habeeb F. Kazimuddin, Bryan Hernandez, Reece Clarke, Colin D. Mcknight, Joy Derwenskus, James Eaton, Rebecca Irlmeier, Fei Ye, Kristin P. O'Grady, Baxter Rogers, Seth A. Smith, Francesca Bagnato
Summary: In this study, we used 7 tesla magnetic resonance imaging to investigate the imaging markers of multiple sclerosis lesions. We found that paramagnetic rim lesions were associated with larger lesion size and lower myelin integrity, while the central vein sign was not associated with these indicators.
JOURNAL OF NEUROIMAGING
(2023)
Article
Pediatrics
Lucia Micheletti, Francisco R. Maldonado, Pankaj Watal, Maria S. Toronchik, Jose I. Erripa, Juan P. Princich, Carlos Rugilo
Summary: Paramagnetic rim lesions on 1.5-T phase-contrast MR images can be helpful in distinguishing pediatric patients with multiple sclerosis from those with other acquired demyelinating syndromes.
PEDIATRIC RADIOLOGY
(2022)
Review
Clinical Neurology
Fabio Giuseppe Masuccio, Giulia Gamberini, Massimiliano Calabrese, Claudio Solaro
Summary: The study reveals a link between brain pathology and depressive symptoms in patients with multiple sclerosis, supporting the hypothesis that structural and functional brain impairment might substantially contribute to the development of depression in these patients. This suggests that depression in multiple sclerosis patients may have a neuro-biological basis and is not merely a consequence of neurological impairment.
NEUROLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
John Conklin, Maria Gabriela Figueiro Longo, Azadeh Tabari, Augusto Lio Goncalves Filho, Wei Liu, Daniel Nicolas Splitthoff, Wei-Ching Lo, Stephen F. Cauley, Kawin Setsompop, Pamela W. Schaefer, John E. Kirsch, Otto Rapalino, Susie Y. Huang
Summary: Wave-SWI showed superior performance compared to T2*w-GRE in terms of pathology visualization, signal dropout artifacts, visualization of normal anatomy, and overall image quality, and was non-inferior to standard SWI. Wave-SWI can be performed in a 1.5 T clinical setting with robust performance and preservation of diagnostic quality.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Saifeng Liu, Jean-Christophe Brisset, Jiani Hu, E. Mark Haacke, Yulin Ge
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonghyun Bae, Jin Zhang, Youssef Zaim Wadghiri, Atul Singh Minhas, Harish Poptani, Yulin Ge, Sungheon Gene Kim
MAGNETIC RESONANCE IN MEDICINE
(2018)
Article
Clinical Neurology
Huaqiang Sheng, Bin Zhao, Yulin Ge
FRONTIERS IN NEUROLOGY
(2019)
Article
Biophysics
Haoyu Wang, Quan Jiang, Yimin Shen, Li Zhang, E. Mark Haacke, Yulin Ge, Shouliang Qi, Jiani Hu
NMR IN BIOMEDICINE
(2020)
Letter
Clinical Neurology
M. Morris, V. M. Zohrabian
AMERICAN JOURNAL OF NEURORADIOLOGY
(2020)
Article
Neuroimaging
Yingkun He, Tao Hong, Meiyun Wang, Liqun Jiao, Yulin Ge, E. Mark Haacke, Tianxiao Li, Hongqi Zhang
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yimin Shen, Jiani Hu, Khalid Eteer, Yongsheng Chen, Sagar Buch, Hani Alhourani, Kamran Shah, Quan Jiang, Yulin Ge, E. Mark Haacke
MAGNETIC RESONANCE IMAGING
(2020)
Article
Clinical Neurology
Sanjeev Chawla, Yulin Ge, Jens Wuerfel, Shadi Asadollahi, Suyash Mohan, Friedemann Paul, Tim Sinnecker, Ilya Kister
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Neurosciences
Sagar Buch, Ying Wang, Min-Gyu Park, Pavan K. Jella, Jiani Hu, Yongsheng Chen, Kamran Shah, Yulin Ge, E. Mark Haacke
Article
Radiology, Nuclear Medicine & Medical Imaging
Rajiv G. Menon, Marcelo V. W. Zibetti, Rajan Jain, Yulin Ge, Ravinder R. Regatte
Summary: This study compared the performance of five compressed sensing algorithms for 3D-T-1 rho mapping of the human brain, finding that EXP and STFD algorithms performed well in image reconstruction quality and whole-brain T-1 rho mapping at different acceleration factors.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Mickael Tordjman, Guillaume Madelin, Pradeep Kumar Gupta, Christine Cordova, Sylvia C. Kurz, Daniel Orringer, John Golfinos, Douglas Kondziolka, Yulin Ge, Ruoyu Luie Wang, Mariana Lazar, Rajan Jain
Summary: This study aimed to assess the disruption of functional connectivity in three brain networks in glioma patients using rsfMRI. The results showed global increased connectivity in the DMN, small areas of increased connectivity in the DAN, and increased connectivity in certain areas of the FPN in glioma patients. There was no significant difference in network connectivity between low- and high-grade gliomas, as well as based on IDH1-R132H mutation status.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zixuan Lin, Dengrong Jiang, Dapeng Liu, Yang Li, Jinsoo Uh, Xirui Hou, Jay J. Pillai, Qin Qin, Yulin Ge, Hanzhang Lu
Summary: The new method can measure BBB permeability to water within 5 minutes with an intrasession, intersession, and inter-vendor test-retest reproducibility of 6% to 9%. This method may provide a useful marker of BBB breakdown in clinical studies.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Clinical Neurology
E. Mark Haacke, Yulin Ge, Sean K. Sethi, Sagar Buch, Paolo Zamboni
Summary: The etiology of multiple sclerosis is believed to be autoimmune, but evidence suggests disrupted vasculature and flow play a significant role. Abnormal flow in the medullary vein system is implicated, with history dating back to the nineteenth century. Vascular effects in MS lesions involve endothelial damage, venous collagenosis, and ultimately lead to inflammatory and demyelinating events.
FRONTIERS IN NEUROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jingyun Chen, Artem V. Mikheev, Han Yu, Matthew D. Gruen, Henry Rusinek, Yulin Ge
Summary: Different partition methods for WMH were evaluated, with the BD method showing advantages in quantifying periventricular white matter hyperintensities over conventional methods in terms of consistency, contrast, and diagnosis accuracy. The BD method also showed stronger clinical correlations than conventional methods.
ACADEMIC RADIOLOGY
(2021)
Article
Neuroimaging
Sagar Buch, Karthikeyan Subramanian, Pavan K. Jella, Yongsheng Chen, Zhen Wu, Kamran Shah, Evanthia Bernitsas, Yulin Ge, E. Mark Haacke
Summary: The study using Ferumoxytol contrast agent revealed vascular abnormalities in MS patients and obtained small vessel densities, providing new insights into the pathophysiology of the disease.
NEUROIMAGE-CLINICAL
(2021)