Article
Cardiac & Cardiovascular Systems
Ze Ming Goh, Nithin Balasubramanian, Samer Alabed, Krit Dwivedi, Yousef Shahin, Alexander M. K. Rothman, Pankaj Garg, Allan Lawrie, David Capener, A. A. Roger Thompson, Faisal Alandejani, Jim M. Wild, Christopher S. Johns, Robert A. Lewis, Rebecca Gosling, Michael Sharkey, Robin Condliffe, David G. Kiely, Andrew J. Swift
Summary: This study investigated the prognostic value of patterns of right ventricular adaptation in patients with pulmonary arterial hypertension (PAH) using cardiac magnetic resonance imaging. The results showed that patients in different volume/mass groups had different survival outcomes, with those in the high-volume-low-mass group having a higher risk of treatment failure.
Article
Engineering, Biomedical
Sotirios Kakaletsis, Marcin Malinowski, J. Caleb Snider, Mrudang Mathur, Gabriella P. Sugerman, Jeffrey J. Luci, Colton J. Kostelnik, Tomasz Jazwiec, Matthew R. Bersi, Tomasz A. Timek, Manuel K. Rausch
Summary: This study investigates the mechanisms of right ventricle stiffening in pulmonary hypertension using a large animal model. The findings suggest that myocardial stiffening is the primary mechanism, correlated with collagen synthesis, and may be a crucial predictor for disease progression. The results provide insights for improving diagnostic, prognostic, and therapeutic strategies in patients with pulmonary hypertension.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Douglas Mesadri Gewehr, Allan Fernando Giovanini, Beatriz Alvarez Mattar, Anelyse Pulner Agulham, Andressa de Souza Bertoldi, Seigo Nagashima, Fernando Bermudez Kubrusly, Luiz Fernando Kubrusly
Summary: This study aimed to establish a rat model of congestive hepatopathy (CH) secondary to right ventricular hypertrophy (RVH) induced by monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). The rat model showed nutmeg-like liver appearance, marked RVH, dilation, and fibrosis. The model was reproducible, safe, and effectively induced CH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Franz P. Rischard, Roberto J. Bernardo, Rebecca R. Vanderpool, Deborah H. Kwon, Tushar Acharya, Margaret M. Park, Austin Katrynuik, Michael Insel, Saad Kubba, Roberto Badagliacca, A. Brett Larive, Robert Naeije, Joe G. N. Garcia, Gerald J. Beck, Serpil C. Erzurum, Robert P. Frantz, Paul M. Hassoun, Anna R. Hemnes, Nicholas S. Hill, Evelyn M. Horn, Jane A. Leopold, Erika B. Rosenzweig, W. H. Wilson Tang, Jennifer D. Wilcox
Summary: The aim of this study is to assess the clinical relevance of a proposed definition for RV functional recovery (RVFnRec). A decrease in RV end-diastolic volume of -15 mL and an increase in compliance had the best predictive value for RVFnRec. RVFnRec is associated with improvements in exercise capacity and clinical worsening.
CIRCULATION-HEART FAILURE
(2023)
Article
Medicine, General & Internal
Yaling Dong, Yu Li, Laichun Song
Summary: This study compared the accuracy of E-es/E-a ratio measured by three different methods in patients with pulmonary artery hypertension and found that CMR combined volume method is a feasible and reliable way to quantitatively evaluate right ventricular function.
Article
Cardiac & Cardiovascular Systems
Faisal Alandejani, Abdul Hameed, Euan Tubman, Samer Alabed, Yousef Shahin, Robert A. Lewis, Krit Dwivedi, Aqeeb Mahmood, Jennifer Middleton, Lisa Watson, Dheyaa Alkhanfar, Christopher S. Johns, Smitha Rajaram, Pankaj Garg, Robin Condliffe, Charlie A. Elliot, A. A. Roger Thompson, Alexander M. K. Rothman, Athanasios Charalampopoulos, Allan Lawrie, Jim M. Wild, Andrew J. Swift, David G. Kiely
Summary: This study highlights the need for guidelines to include measures of RV function rather than RA area alone to aid the risk stratification of patients with PAH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Rebecca R. Vanderpool, Kendall S. Hunter, Michael Insel, Joe G. N. Garcia, Edward J. Bedrick, Ryan J. Tedford, Franz P. Rischard
Summary: In patients with advanced PAH, RV-pulmonary arterial coupling could not differentiate irreversible RV failure at presentation, but showed an improving trend by follow-up. Early change in Eed and baseline RV ejection fraction were the best predictors of therapeutic response.
Article
Medicine, General & Internal
Remigiusz Kazimierczyk, Ewelina Kazimierczyk, Malgorzata Knapp, Bozena Sobkowicz, Lukasz A. Malek, Piotr Blaszczak, Katarzyna Ptaszynska-Kopczynska, Ryszard Grzywna, Karol A. Kaminski
Summary: The study showed that the TAPSE/sPAP ratio in patients with pulmonary arterial hypertension (PAH) is a valuable prognostic parameter for assessing hemodynamic adaptation and predicting outcomes, providing an easy and reliable non-invasive tool for comprehensive evaluation of patients' condition.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Wenqian Zhai, Yunfei Li, Yongjuan Luo, Weidong Gao, Shan Liu, Jiange Han, Jie Gen
Summary: Sevoflurane has potential benefits for right heart function in rats with experimental pulmonary arterial hypertension, reducing pulmonary vascular remodeling and RVH by down-regulating inflammatory factors, decreasing oxidative stress levels, and inhibiting NF-kappa B and MAPK pathways.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Tsukasa Shimauchi, Olivier Boucherat, Tetsuro Yokokawa, Yann Grobs, WenHui Wu, Mark Orcholski, Sandra Martineau, Junichi Omura, Eve Tremblay, Kana Shimauchi, Valerie Nadeau, Sandra Breuils-Bonnet, Roxane Paulin, Francois Potus, Steeve Provencher, Sebastien Bonnet
Summary: The authors demonstrate that increased expression of PARP1 and PKM2 is a common feature of a decompensated right ventricle in patients with pulmonary arterial hypertension and animal models. They find that overactivation of PARP1 promotes cardiomyocyte dysfunction by favoring PKM2 expression and nuclear function, glycolytic gene expression, and activation of proinflammatory factors. Inhibition of PARP1 or enhanced tetramerization of PKM2 improves right ventricular function in multiple rodent models.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Ryotaro Asano, Takeshi Ogo, Yoshiaki Morita, Akiyuki Kotoku, Tatsuo Aoki, Kyoko Hirakawa, Sayuri Nakayama, Jin Ueda, Akihiro Tsuji, Mark T. Waddingham, Yasutoshi Ohta, Tetsuya Fukuda, Keiko Ohta-Ogo, Hatsue Ishibashi-Ueda, Teruo Noguchi, Satoshi Yasuda
Summary: The study found that native T1 values of the right ventricular free wall were significantly higher in patients with pulmonary arterial hypertension compared to controls, and were better correlated with right ventricular elastance, ventricular-arterial uncoupling, and serum brain natriuretic peptide levels. Additionally, baseline RVT1 was an accurate predictor of reduced right ventricular ejection fraction at 12-month follow-up and independently associated with composite events of death or hospitalization. This suggests that native T1 mapping in the right ventricular free wall may be an effective prognostic method for pulmonary arterial hypertension.
Article
Physiology
Juan C. Grignola, Enric Domingo, Manuel Lopez-Meseguer, Pedro Trujillo, Carlos Bravo, Santiago Perez-Hoyos, Antonio Roman
Summary: In prevalent and stable PAH patients, the severity of proximal PA remodeling is related to risk stratification and associated with PAC and RV-PA coupling impairment, beyond the indirect effect of mean PA pressure. The concomitant assessment of IVUS and hemodynamic parameters could be a feasible and safe tool for risk stratification and treatment response of PA vasculopathy in PAH patients.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pediatrics
Meindina G. G. Haarman, Iris Coenraad, Quint A. J. Hagdorn, Hans L. L. Hillege, Tineke P. P. Willems, Rolf M. F. Berger, Johannes M. M. Douwes
Summary: Cardiac magnetic resonance (CMR)-derived measures of right ventricular (RV) morphology and function can predict the outcome of children with pulmonary arterial hypertension (PAH), which is crucial for treatment strategies.
Article
Cardiac & Cardiovascular Systems
Megan M. Lowery, Nicholas S. Hill, Lu Wang, Erika B. Rosenzweig, Aparna Bhat, Serpil Erzurum, J. Emanuel Finet, Christine L. Jellis, Sunjeet Kaur, Deborah H. Kwon, Rawan Nawabit, Milena Radeva, Gerald J. Beck, Robert P. Frantz, Paul M. Hassoun, Anna R. Hemnes, Evelyn M. Horn, Jane A. Leopold, Franz P. Rischard, Reena Mehra
Summary: In this study, the association between sleep-related hypoxia and apnea-hypopnea index (AHI) with right ventricular (RV) function and survival in patients with group 1 pulmonary arterial hypertension (PAH) was prospectively evaluated. The results showed that sleep-related hypoxia was more strongly associated than AHI with measures of RV dysfunction, death, or transplantation overall and in group 1 non-CTD-associated PAH but only with RV dysfunction in CTD-associated PAH.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Aleksandra Bartnik, Joanna Pepke-Zaba, Stephen P. Hoole, Paul White, Madalina Garbi, John G. Coghlan, Fouad Taghavi, Steven Tsui, Jonathan Weir-McCall
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a condition that occurs in some patients with prior acute pulmonary embolism, characterized by shortness of breath, persistently elevated pulmonary pressures, and right heart failure. Surgical pulmonary endarterectomy (PEA) is effective for patients with proximal disease distribution, while balloon pulmonary angioplasty (BPA) and medical therapy are options for those with inoperable disease. Current evaluation of pulmonary hemodynamics does not accurately reflect patient symptoms, and further research is needed on how to manage symptomatic patients without pulmonary hypertension.
Editorial Material
Cardiac & Cardiovascular Systems
Chiara Bucciarelli-Ducci, Panos Vardas
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Thomas H. Marwick, Alessia Gimelli, Sven Plein, Jeroen J. Bax, Phillippe Charron, Victoria Delgado, Erwan Donal, Patrizio Lancellotti, Eylem Levelt, Pal Maurovich-Horvat, Stefan Neubauer, Gianluca Pontone, Antti Saraste, Bernard Cosyns, Thor Edvardsen, Bogdan A. Popescu, Maurizio Galderisi, Genevieve Derumeaux
Summary: Heart failure is a significant complication of diabetes mellitus, and detecting subclinical dysfunction may help reduce its incidence. However, there is insufficient evidence for heart failure screening in diabetes patients, and further research is needed to establish the relationship between detection, treatment, and improved outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Kate Liang, Eleni Nakou, Marco Giuseppe Del Buono, Rocco Antonio Montone, Domenico D'Amario, Chiara Bucciarelli-Ducci
Summary: Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) accounts for a significant portion of acute myocardial infarction cases, but is characterized by the absence of obstructive coronary disease. This can present a diagnostic challenge, and the use of cardiac magnetic resonance (CMR) imaging has proven valuable in aiding clinicians in differential diagnosis and identifying non-ischemic causes of myocardial injury. CMR's role in suspected MINOCA is increasingly recognized and emphasized in clinical guidelines.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Chiara Bucciarelli-Ducci, Nina Ajmone-Marsan, Marcelo Di Carli, Edward Nicol
Summary: This article reviews the latest research literature published in 2021 on the role of cardiovascular imaging in cardiovascular medicine. COVID-19 has had a continuous impact on the healthcare field, resulting in limited access to hospital-based cardiovascular care and routine diagnostic cardiovascular testing. However, imaging techniques have also contributed to understanding the myocardial damage caused by the coronavirus infection. Apart from the pandemic, the imaging literature has focused on valvular heart disease, the increasing use of artificial intelligence in imaging, and the use of advanced imaging modalities in ischemic heart disease and cardiac amyloidosis.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Article
Cardiac & Cardiovascular Systems
Matthew G. L. Williams, Kate Liang, Estefania De Garate, Lucrezia Spagnoli, Emiliano Fiori, Amardeep Dastidar, Umberto Benedetto, Giovanni Biglino, Thomas W. Johnson, Thomas Luscher, Chiara Bucciarelli-Ducci
Summary: Cardiac magnetic resonance (CMR) has a high diagnostic yield in patients with acute coronary syndrome (ACS) and nonobstructive coronary arteries, especially when combined with peak troponin levels.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Augustin Coisne, Blazej Michalski, Hatem Soliman, Nina Ajmone, Robin Nijveldt, Ivan Stankovic, Erwan Donal, Joost van der Maaten, Constantinos Papadopoulos, Thor Edvardsen, Denisa Muraru, Steffen E. Petersen, Bernard Cosyns
Summary: The study aimed to assess the level of transesophageal echocardiography (TOE) knowledge and skills among young cardiologists. Results from an online evaluation showed a relatively low level of TOE skills and knowledge among young cardiologists worldwide. Prior participation in TOE simulation-based training, a higher number of TOE exams performed per week, and EACVI certification for TOE were independently associated with higher scores.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew G. L. Williams, Amardeep Dastidar, Kate Liang, Thomas W. Johnson, Anna Baritussio, Julian Strange, Nikhil Joshi, Stephen Dorman, Estefania De Garate, Lucrezia Spagnoli, Emiliano Fiori, Christopher Lawton, Giovanni Biglino, Sven Plein, Chiara Bucciarelli-Ducci
Summary: This study evaluates the impact of sex on clinical presentation and outcome in patients with suspected ACS and non-obstructive coronary arteries. The results show that sex does not have a significant effect on all-cause mortality, but men are more likely to have non-ischemic causes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Froso Sophocleous, Lucy Standen, Gemina Doolub, Reem Laymouna, Chiara Bucciarelli-Ducci, Massimo Caputo, Nathan Manghat, Mark Hamilton, Stephanie Curtis, Giovanni Biglino
Summary: This study investigated the relationship between left ventricular (LV) morphological characteristics and LV function as well as thoracic aortic morphology in patients with aortic coarctation. The results showed that the shape of the LV was associated with LV function and the presence of aortic coarctation, but not with aortic arch architecture.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Froso Sophocleous, Estefania De Garate, Maria Giulia Bigotti, Maryam Anwar, Eva Jover, Aranzazu Chamorro-Jorganes, Cha Rajakaruna, Konstantina Mitrousi, Viola De Francesco, Aileen Wilson, Serban Stoica, Andrew Parry, Umberto Benedetto, Pierpaolo Chivasso, Frances Gill, Mark C. K. Hamilton, Chiara Bucciarelli-Ducci, Massimo Caputo, Costanza Emanueli, Giovanni Biglino
Summary: This study identified new miRNAs involved in the BAV aortic wall and revealed the concomitant expressional dysregulation of miRNAs, proteins, and elastic fibers on the anterior/right wall in dilated BAV patients, corresponding to regions of elevated wall shear stress (WSS).
Article
Cardiac & Cardiovascular Systems
Andreas Baumbach, Yu-Xin Cui, Rebecca N. Evans, Lucy Culliford, Tom Johnson, Chris A. Rogers, Barnaby C. Reeves, Chiara Bucciarelli-Ducci, Jessica Harris, Mark Hamilton, Paolo Madeddu
Summary: This study investigates the influence of myocardial infarction severity and diabetes on the migratory activity of CD34+/CXCR4+ progenitor cells and attempts to predict cardiac outcomes. The results show an interaction between infarct and diabetes on the migratory activity of CD34+/CXCR4+ cells, but the test does not accurately predict functional outcomes in patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kate Liang, Matthew Williams, Chiara Bucciarelli-Ducci
Summary: This article reports a case of myocardial infarction caused by paradoxical coronary embolism due to a patent foramen ovale. The use of various diagnostic methods to determine the source of the embolism and intra-cardiac shunt led to the appropriate treatment for the patient.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Mrinali Shetty, Niti R. Aggarwal, Purvi Parwani, Chiara Bucciarelli-Ducci, Juan Lopez-Mattei, Andrew Choi, Lars Grosse-Wortmann
Summary: Social media has become crucial in cardiac imaging conferences, allowing for increased conference reach and global engagement. The COVID-19 pandemic necessitated virtual conferences, requiring a modified social media strategy to recreate the sociability and promote global dissemination of scientific findings. The experience of the SCMR annual meeting serves as a model for future cardiovascular conferences.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Review
Cardiac & Cardiovascular Systems
Andrew E. Arai, Raymond Y. Kwong, Michael Salerno, John P. Greenwood, Chiara Bucciarelli-Ducci
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)
Article
Cardiac & Cardiovascular Systems
Ankur Pandya, Yuan-Jui Yu, Yin Ge, Eike Nagel, Raymond Y. Kwong, Rafidah Abu Bakar, John D. Grizzard, Alexander E. Merkler, Ntobeko Ntusi, Steffen E. Petersen, Nina Rashedi, Juerg Schwitter, Joseph B. Selvanayagam, James A. White, James Carr, Subha V. Raman, Orlando P. Simonetti, Chiara Bucciarelli-Ducci, Lilia M. Sierra-Galan, Victor A. Ferrari, Mona Bhatia, Sebastian Kelle
Summary: Based on the research, cardiovascular magnetic resonance (CMR) is usually a cost-effective option compared to relevant comparators for assessing significant coronary artery disease. The findings suggest that CMR can provide both health benefits and cost savings, making it a favorable choice for evaluating CAD.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2022)