期刊
JOURNAL OF MAGNETIC RESONANCE
卷 204, 期 1, 页码 50-55出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2010.01.016
关键词
Hyperpolarization; PHIP; C-13 NMR; Barbituric acid; Polarization transfer
资金
- German Research Foundation (DFG) [FOR 474]
Significant C-13 NMR signal enhancement by a factor of 5000 of a barbituric acid derivative (5-methyl-5-propenyl-barbituric acid) via parahydrogen induced polarization is presented. This hyperpolarization is achieved by hydrogenating 5-methyl-5-propargyl-barbituric acid with 98% enriched para-H-2 under elevated temperature and pressure and transferring the initially created H-1 hyperpolarization with an INEPT-derived pulse sequence to 13C. The polarization can be selectively transferred to different carbons in the barbituric acid derivative by applying different pulse delays in the INEPT pulse sequence. These results demonstrate the potential of using hyperpolarized barbituric acid derivatives as active contrast agents in MRI and visualizing their pharmacokinetics in vivo. (C) 2010 Elsevier Inc. All rights reserved.
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