Article
Immunology
Maolin Ma, Qipeng Sun, Xiujie Li, Gengguo Deng, Yannan Zhang, Zhe Yang, Fei Han, Zhengyu Huang, Youqiang Fang, Tao Liao, Qiquan Sun
Summary: This study investigated the effect of IL-6/IL-6R signaling blockade on acute antibody-mediated rejection (AAMR) and found that the blockade significantly reduced graft injury and improved survival. Mechanistic research showed that the blockade decreased B cell numbers, inhibited antibody production and complement activation, and reduced inflammatory cell infiltration in allografts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Pengcheng Luo, Yina Wang, Chongqiang Zhao, Junyi Guo, Wei Shi, Haiyan Ma, Tianshu Liu, Dan Yan, Shengqi Huo, Moran Wang, Chenglong Li, Jiayuh Lin, Sheng Li, Jiagao Lv, Cuntai Zhang, Li Lin
Summary: Bazedoxifene effectively attenuated atherosclerotic plaque area and down-regulated IL-6 levels in ApoE-deficient mice, suggesting its potential as a novel therapeutic reagent for atherosclerosis by regulating the IL-6/IL-6R/STAT3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Surgery
Maeva Massat, Nicolas Congy-Jolivet, Anne-Laure Hebral, Laure Esposito, Olivier Marion, Audrey Delas, Magali Colombat, Stanislas Faguer, Nassim Kamar, Arnaud Del Bello
Summary: This study found that monthly infusions of tocilizumab did not alter the progression of antibodies in patients with antibody-mediated rejection resistant to standard of care therapy. There were no significant differences in graft survival and decline in renal function between patients who received tocilizumab and those who did not. Despite a decrease in inflammation and tubulitis scores, the course of antibody-mediated lesions and chronic glomerulopathy were similar in both groups.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Oncology
Jiuhui Xu, Chenglong Chen, Kunkun Sun, Qianyu Shi, Boyang Wang, Yi Huang, Tingting Ren, Xiaodong Tang
Summary: This study found that interleukin-6 (IL-6) and its downstream pathway STAT3 were activated in anlotinib-resistant osteosarcoma. Tocilizumab, an anti-IL-6 receptor drug, can block tumor progression in anlotinib-resistant OS cells by inhibiting STAT3 expression. Combination treatment with anlotinib enhances these effects. IL-6 is highly expressed in osteosarcoma patients and is associated with poor prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Xiaole Chen, Shuangyu Tan, Mengru Yan, Kaimei Nie, Qingmei Zheng, Yaduan Wang, Rui Liu, He Wang, Juhua Yang, Nanwen Zhang
Summary: The study developed an anti-TNF-α/HSA/IL-6R triple-specific fusion protein, showing its potential protective effects in treating sepsis. TAL-6 demonstrated a reduction in cytokine levels, alleviation of pathological injuries, and increased survival rate, making it a promising candidate for new drug development against sepsis.
Review
Biochemistry & Molecular Biology
Natsuki Eguchi, Kimia Damyar, Michael Alexander, Donald Dafoe, Jonathan R. T. Lakey, Hirohito Ichii
Summary: Islet cell transplantation is a favorable therapeutic approach for Type 1 Diabetes, but there are limitations in the process, including oxidative stress that leads to the loss of islet cells. Therefore, exploring the application of antioxidants in transplantation is crucial.
Article
Surgery
Cyril P. Landstra, Michiel F. Nijhoff, Dave L. Roelen, Aiko P. J. de Vries, Eelco J. P. de Koning
Summary: Islet transplantation stabilizes glycemic control in patients with complicated diabetes mellitus, but rapid functional decline could be due to islet allograft rejection. Currently, there is no reliable method for assessing rejection and treatment protocols are lacking. This study aimed to identify diagnostic features of islet allograft rejection and evaluate the effectiveness of high-dose methylprednisolone treatment.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Torbjorn F. Heldal, Anders Asberg, Thor Ueland, Anna V. Reisaeter, Soren E. Pischke, Tom E. Mollnes, Pal Aukrust, Finn Reinholt, Anders Hartmann, Kristian Heldal, Trond G. Jenssen
Summary: Early systemic inflammation after kidney transplantation is associated with long-term graft pathology and loss, with particular emphasis on vascular inflammation scores correlating with inflammatory findings in biopsies 6 weeks and 1 year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Thomas Pomposelli, Christian Schuetz, Ping Wang, Kazuhiko Yamada
Summary: Islet cell transplantation as a pre-vascularized composite islet-kidney graft has shown promise in providing long term durable blood glucose control, but is limited by the long term immunosuppression requirements. Strategies aimed at inducing host tolerance to the allogeneic and xenogeneic islet-kidney grafts could potentially avoid long-term immunosuppression and provide a near-limitless organ supply. This could lead to a durable and long-term cure for diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Dengli Wang, Daiki Ousaka, Handong Qiao, Ziyi Wang, Kun Zhao, Shangze Gao, Keyue Liu, Kiyoshi Teshigawara, Kenzo Takada, Masahiro Nishibori
Summary: This study found that humanized anti-HMGB1 mAb can inhibit the release of HMGB1, reduce the accumulation of 4-HNE and cerebral iron deposition, and decrease brain injury volume in the ICH model. In vitro experiments showed that recombinant HMGB1 delayed hemoglobin clearance, allowing the toxic effects of hemoglobin, heme, and Fe2 + to persist. Additionally, humanized anti-HMGB1 mAb reduced body weight loss and improved behavioral performance after ICH.
Article
Medicine, Research & Experimental
Mingqing Song, Zachary W. Fitch, Kannan P. Samy, Benjamin M. Martin, Qimeng Gao, Robert Patrick Davis, Francis V. Leopardi, Niki Huffman, Robin Schmitz, Gayathri R. Devi, Bradley H. Collins, Allan D. Kirk
Summary: The study reveals that xenogeneic islet transplantation activates both intrinsic and extrinsic coagulation pathways, with hCD46 expression playing a significant role in reducing thrombosis. Layers of TF-positive inflammatory cells and fibroblasts identified around islets within 24 hours may have crucial roles in the events of thrombosis, inflammatory cell recruitment, rejection, and graft outcome progression.
XENOTRANSPLANTATION
(2021)
Article
Surgery
Sehoon Park, Seung-Hee Yang, Jiyeon Kim, Semin Cho, Jaeseok Yang, Sang-Il Min, Jongwon Ha, Chang Wook Jeong, Seong Hee Bhoo, Yong Chul Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Kyung Chul Moon, Eun Young Song, Hajeong Lee
Summary: The study found that post-transplant anti-collagen type I and type III antibodies may be novel non-HLA antibodies related to antibody-mediated rejection (ABMR) of kidney allografts.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Malik Zaben, Niels Haan, Feras Sharouf, Aminul Ahmed, Lars E. Sundstrom, William P. Gray
Summary: The study identified a HMGB1 and IL-1 beta-mediated environmental anti-neurogenic effect in human temporal lobe epilepsy, with IL-1R and TLR 2/4 receptors as potential drug targets for restoring human hippocampal neurogenesis in TLE.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Ji Lei, Maria M. Coronel, Esma S. Yolcu, Hongping Deng, Orlando Grimany-Nuno, Michael D. Hunckler, Vahap Ulker, Zhihong Yang, Kang M. Lee, Alexander Zhang, Hao Luo, Cole W. Peters, Zhongliang Zou, Tao Chen, Zhenjuan Wang, Colleen S. McCoy, Ivy A. Rosales, James F. Markmann, Haval Shirwan, Andres J. Garcia
Summary: We report a strategy of cotransplanting allogeneic islets and streptavidin (SA)-FasL-presenting microgels to the omentum under transient rapamycin monotherapy, which resulted in robust glycemic control, sustained C-peptide levels, and graft survival in diabetic nonhuman primates. This localized immunomodulatory strategy shows translational potential in beta cell replacement for treating type 1 diabetes.
Article
Multidisciplinary Sciences
Mingkun Chen, Yi Zhou, Miao Xue, Rongrong Zhu, Liling Jing, Liling Lin, Chengwen He, Yanghua Qin
Summary: Sjogren's syndrome (SS) is a common chronic inflammatory autoimmune disease that affects about 0.33-0.77% of the population in China. The presence of anti-HMGB1 antibodies may be one of the characteristic autoantibodies of SS. Detection of anti-HMGB1 antibodies can provide additional laboratory evidence for the clinical diagnosis of SS.
SCIENTIFIC REPORTS
(2022)