Editorial Material
Multidisciplinary Sciences
Joanne Liu, Helen Clark, Michel Kazatchkine
Summary: Heads of state and government have the responsibility to prevent future pandemics.
Review
Medicine, Research & Experimental
Tomohiro Enokida, Alvaro Moreira, Nina Bhardwaj
Summary: Preventive cancer vaccines have shown promising results in targeting oncogenic viruses, such as HPV and HBV, but face challenges in eliminating established cancer. Ongoing research is also focusing on nonviral antigens to develop effective cancer-preventive vaccines.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Lauri E. Markowitz, John T. Schiller
Summary: HPV vaccines are highly effective in preventing HPV-attributable cancers and have been introduced into national immunization programs in over 100 countries. The success of these vaccines has sparked interest in ambitious disease reduction goals.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Virology
Lucijan Skubic, Lea Hosnjak, Jeannette P. Staheli, Michael R. Dyen, Rebecca M. Ducore, Lois M. A. Colgin, Anne D. Lewis, Mario Poljak
Summary: This study describes the first detection and characterization of papillomaviruses infecting Japanese macaques, with evidence of their etiological association with the development of original neoplasms. Molecular and phylogenetic analyses revealed distinct features of the two viruses, but additional experimental evidence is required for confirmation.
Article
Pharmacology & Pharmacy
Ridhima Jasrotia, Daljeet Singh Dhanjal, Sonali Bhardwaj, Parvarish Sharma, Chirag Chopra, Reena Singh, Anupam Kumar, Anamika Mubayi, Deepak Kumar, Raj Kumar, Abhineet Goyal
Summary: Cervical cancer, caused by Human papillomavirus (HPV), is the most common gynecological malignancy globally and a major cause of cancer-related death in women. HPV vaccines are effective in preventing neoplastic disease and infection, but not in treating established infection. Therapeutic vaccines targeting early genes E6 and E7 have been developed, and nanotechnological approaches are being explored for targeted delivery of therapeutic agents. This review comprehends the current knowledge about cervical cancer and conventional approaches for its treatment, as well as recent developments in vaccine strategies and nanotechnological approaches for effective management and prevention.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
News Item
Multidisciplinary Sciences
Max Kozlov, Heidi Ledford
Summary: The long-awaited decision is finally announced after more than a year since Francis Collins resigned as the director of the world's largest public funder of biomedical research.
Article
Public, Environmental & Occupational Health
Sharifah Sekalala, Katrina Perehudoff, Michael Parker, Lisa Forman, Belinda Rawson, Maxwell Smith
Summary: This paper discusses the practical implementation of human rights law in COVID-19 vaccine allocation, highlighting the need for broader consideration of intersectional needs in society and prioritization of vulnerable groups. It suggests that vaccines should be allocated based on infection risk, social vulnerabilities, and potential impact of illness.
News Item
Multidisciplinary Sciences
Jeff Tollefson, Max Kozlov, Amy Maxmen, Alexandra Witze
Summary: This article assesses whether the US president has fulfilled his promise of making evidence-based decisions in his first year in office.
Review
Immunology
Ditte Rahbaek Boilesen, Karen Norgaard Nielsen, Peter Johannes Holst
Summary: HPV infection is the leading cause of cervical and head and neck cancers globally, with vaccines and screening programs proving effective in prevention. However, cervical cancer remains a significant cause of morbidity and mortality, especially in developing countries. Therefore, the development of more effective therapeutic vaccines is crucial in combating HPV-related cancers.
News Item
Multidisciplinary Sciences
Smriti Mallapaty
Summary: The National People's Congress and the Chinese People's Political Consultative Conference have elevated the importance of science and technology in the national agenda.
Article
Health Care Sciences & Services
Toshihiro Yamaguchi, Masao Iwagami, Chieko Ishiguro, Daisuke Fujii, Norihisa Yamamoto, Manabu Narisawa, Takashi Tsuboi, Hikari Umeda, Natsumi Kinoshita, Toyotaka Iguchi, Tatsuya Noda, Shinya Tsuruta, Akira Oka, Tomohiro Morio, Kiyohito Nakai, Shuichiro Hayashi
Summary: The assessment of the efficacy and safety of COVID-19 vaccines is crucial, and in Japan, a joint council regularly evaluates adverse events following vaccination and takes safety-related regulatory actions. Sharing vaccine safety information and evaluation systems internationally is important for better monitoring of COVID-19 vaccine safety.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Review
Dentistry, Oral Surgery & Medicine
L. L. Hagenaars, P. P. T. Jeurissen, N. S. Klazinga, S. Listl, M. Jevdjevic
Summary: Global sugar consumption is increasing and posing detrimental health effects, leading to the consideration of sugar-sweetened beverage (SSB) taxes to reduce sugar consumption. However, implementing such policies requires consideration of various factors beyond evidence alone. Policymaking on SSB taxes should take into account existing problems, public sentiment, tax regulations, and the need for a comprehensive and context-sensitive approach.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Jhoys Landicho-Guevarra, Mark Donald C. Renosa, Jonas Wachinger, Vivienne Endoma, Mila F. Aligato, Thea Andrea Bravo, Jeniffer Landicho, Kate Baernighausen, Shannon A. McMahon
Summary: Vaccine hesitancy is a significant threat to global health, particularly in low- and middle-income countries like the Philippines. This study explores reasons for delay or refusal of childhood vaccinations, including fear of side effects and negative experiences from past vaccine controversies. Vaccine hesitant caregivers also expressed concerns about healthcare workers' ability to address their questions and treat their concerns respectfully.
Editorial Material
Health Policy & Services
Michael R. Reich
Summary: This commentary reflects on the author's work over the past five decades in the field of health systems politics and policies from various perspectives. It is based on a plenary lecture given at the Seventh Global Symposium on Health Systems Research in Bogota, Colombia, in November 2022. The commentary discusses the persistent challenge of how the powerless can influence policy, examining the role of social protest movements, the impact of political leadership, and the relevance of political analysis. The author hopes that these reflections will contribute to the use of applied political analysis in public health and lead to improved health and health equity worldwide.
HEALTH SYSTEMS & REFORM
(2023)
Review
Biochemistry & Molecular Biology
Ting Fan, Mingna Zhang, Jingxian Yang, Zhounan Zhu, Wanlu Cao, Chunyan Dong
Summary: With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies, cancer immunotherapy has undergone a profound transformation over the past decades. Recently, therapeutic cancer vaccines have shown promise by eliciting de novo T cell responses targeting tumor antigens. However, current clinical attempts toward developing cancer vaccines have not yielded breakthrough clinical outcomes due to significant challenges.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)