Article
Obstetrics & Gynecology
Michelle van der Linden, Colette L. van Hees, Marc van Beurden, Johan Bulten, Eleonora B. van Dorst, Martha D. Esajas, Kim A. Meeuwis, Dorry Boll, Mariette van Poelgeest, Joanne A. de Hullu
Summary: This study investigated the effectiveness, safety, and impact on quality of life of a standardized treatment using 5% imiquimod cream for noninvasive vulvar Paget disease. The study included 24 patients who were treated with topical 5% imiquimod cream three times a week for 16 weeks. The results showed that 82.6% of the patients responded to the treatment, with a complete response reported in 52.2% of the patients. Adverse effects such as fatigue and headaches were observed, and some patients needed painkillers during treatment. The treatment improved patients' quality of life, but a slight temporary negative impact was observed during treatment. Recurrence of the disease was observed in some patients after 1 year.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Geriatrics & Gerontology
Fulvio Borella, Mario Preti, Pedro Vieira-Baptista, Faustino R. Perez-Lopez, Luca Bertero, Niccolo Gallio, Leonardo Micheletti, Chiara Benedetto
Summary: This study analyzed the effectiveness and safety of topical imiquimod in a large cohort of patients with Vulvar Paget's disease. The results showed that treatment with imiquimod is safe and effective in reducing the recurrence rate of VPD.
Review
Oncology
Chamorro Perez Jesus, Cortes Salgado Alfonso, Perez-Mies Belen, Dominguez Rullan Jose Antonio, Ajuria-Illarramendi Odile, Guerra Alia Eva Maria, Juan Jose Serrano Domingo
Summary: This article reviews the purpose of the study, recent findings, and treatment approaches for Extramammary Paget disease (EMPD). EMPD is a rare tumor of uncertain origin, and treatment can involve various methods including surgery, radiotherapy, photodynamic therapy, chemotherapy, and targeted therapy. The article highlights the need for further research and diagnostic tools to guide therapeutic decisions for EMPD.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Medical Laboratory Technology
Anastasia M. Konstantinova, Dmitry Kazakov
Summary: Extramammary Paget disease is a rare neoplasm that typically occurs in the vulva and is characterized by slow growth and high recurrence rates. This article reviews the epidemiological, clinical, morphological, genetic, and treatment features of vulvar EMPD reported in recent years.
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2021)
Article
Dermatology
Krzysztof G. Sadko, Anna Plaszczynska, Justyna Czarny
Summary: This article reports a case of extramammary Paget disease of the vulva with positive margins after vulvectomy. Local therapy with imiquimod achieved clinical improvement, and remission was confirmed in long-term follow-up.
PRZEGLAD DERMATOLOGICZNY
(2022)
Article
Medicine, General & Internal
Miriam Dellino, Giulio Gargano, Raffele Tinelli, Carmine Carriero, Carla Minoia, Skrypets Tetania, Erica Silvestris, Vera Loizzi, Angelo Paradiso, Porzia Casamassima, Antonio Tufaro, Gennaro Cormio, Vito Michele Garrisi
Summary: This study aimed to evaluate the role of HE4 and CA125 in early identification of PVD and during relapses. The research included 50 patients, with no significant changes in CA125 and HE4 levels before and after surgery in PVD patients. HE4 showed significant differences between PVD patients and the control group, while CA125 was not sensitive for PVD. This suggests HE4 may be helpful in early identification of PVD.
Article
Obstetrics & Gynecology
Varsha Shah, Lindsay Bergin, Gareth L. Rowlands, W. Glenn McCluggage
Summary: Vulval extramammary Paget disease (vEMPD) is a rare malignant tumor that can occur as a primary or secondary condition. This article reports two cases of metaplastic MGLA of the vulva and proposes a new hypothesis that some cases of vulval MGLA may originate from Paget disease. Additionally, a unique case of secondary vEMPD resulting from the spread of urothelial carcinoma in situ is also reported.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Anna Daniela Iacobone, Maria Elena Guerrieri, Eleonora Petra Preti, Noemi Spolti, Gianluigi Radici, Giulia Peveri, Vincenzo Bagnardi, Giulio Tosti, Angelo Maggioni, Fabio Bottari, Chiara Scacchi, Mariacristina Ghioni
Summary: In this retrospective analysis, the incidence, clinical and pathological features of cervico-vaginal involvement in extra-mammary Paget's disease (EMPD) of the vulva were investigated. It was found that 2.5% of patients developed cervico-vaginal involvement at 5 years, 6.5% at 10 years, and 14.0% at 15 years. Abnormal glandular cytology was the primary method of detection, and most patients had invasive EMPD and required hysterectomy with colpectomy. Liquid-based cytology with immunocytochemistry was recommended for early diagnosis and lifelong follow-up.
Review
Surgery
Y. Bencherifi, Imane El Abbassi, A. Amghar, M. Ennachit, M. Benhessou, M. Elkarroumi
Summary: Paget disease of de Vulva is a rare neoplastic intraepithelial pathology that is mainly treated with surgical excision. This case report describes a patient with vulvar Paget's disease who underwent surgery for extensive and recurrent lesions. The diagnosis and management of Paget disease require careful consideration, and prognostic factors play a crucial role in treatment selection and disease progression.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Medicine, General & Internal
Hiroki Hashimoto, Yumiko Kaku-Ito, Masutaka Furue, Takamichi Ito
Summary: This study retrospectively analyzed 21 patients with distant metastatic EMPD and found that while chemotherapy can prolong progression-free survival, it did not significantly improve overall survival. Considering the frequent adverse events of conventional chemotherapy, targeted therapy may become a mainstay for the treatment of metastatic EMPD in the future.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Aman Goyal, Anuradha Bishnoi, Hitaishi Mehta, Debajyoti Chatterjee, Bhavana Rai, Rashmi Bagga, Muthu Sendhil Kumaran
Summary: This case report aims to raise awareness and knowledge about Extramammary Paget's disease (EMPD), a rare intraepithelial adenocarcinoma, by presenting a case of ulcerated plaque on the genital region.
INTERNATIONAL JOURNAL OF STD & AIDS
(2023)
Article
Pathology
Steffanie Charlyne Tamayo, M. Ruhul Quddus, Kamaljeet Singh
Summary: The article discusses a case of recurrent primary vulvar Paget disease with atypical histomorphology suggesting displacement of Paget cells in the dermis. The authors compare the histology of this case with other known invasive vulvar Paget disease cases.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Health Care Sciences & Services
Luigi Della Corte, Valeria Cafasso, Carmine Conte, Lara Cuomo, Pierluigi Giampaolino, Giada Lavitola, Giuseppe Bifulco
Summary: This study analyzed the medical and surgical strategies for the treatment of Vulvar Paget's disease (VPD). It found that both surgical excision and medical conservative treatment have certain effectiveness, but the disease has a high recurrence rate. The best type of therapy should be tailored based on individual patient characteristics and biopsy histopathologic findings.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Gabriela Veronica Pinget, Jian Kai Tan, Duan Ni, Jemma Taltz, Claire Immediato Daien, Julie Mielle, Robert John Moore, Dragan Stanley, Stephen Simpson, Nicholas Jonathan Cole King, Laurence Macia
Summary: This study demonstrates that psoriasis disrupts gut homeostasis in mice, leading to an increased susceptibility to inflammatory bowel disease. This suggests a two-hit requirement, involving psoriasis-induced altered gut homeostasis and a secondary environmental challenge.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Stefan Govers, Friso M. van der Zant, Maurits Wondergem, Wouter A. M. Broos, Remco J. J. Knol
Summary: An 81-year-old woman was evaluated for a stroke, with imaging studies showing diffuse abnormalities in the neurocranium. F-18-NA PET/CT was able to differentiate between various possible diagnoses, ultimately diagnosing the patient with monostotic Paget disease based on imaging findings and laboratory tests.
CLINICAL NUCLEAR MEDICINE
(2021)
