期刊
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
卷 31, 期 8, 页码 1147-1161出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10826070802000665
关键词
enantioseparation; chiral stationary phase; Chiralpak AD-H; Kromasil CHI-TBB; paroxetine precursors; HPLC
Two important precursors of antidepressant trans-(-)-paroxetine, i.e., trans-4-(4'-fluorophenyl)-3-hydroxymethyl-1-methylpiperidine and trans-3- ethoxycarbonyl-4-(4'-fluorophenyl)-1-methylpiperidine-2,6-dione have been directly separated by HPLC on Chiralpak AD-H and Kromasil CHI-TBB columns. All the experiments were conducted in the normal phase mode. The mobile phases were mixtures of n-hexane and alcohol modifiers including ethanol, 2-propanol, and 1-propanol, with or without addition of diethylamine. Excellent separation was obtained for both enantiomers. Effects of the type and content of polar alcohol modifiers on enantioseparation was investigated. An unusual retention behavior was observed, i.e., the retention of enantiomers increased when the alcohol modifier was changed from 2-propanol to ethanol. The elution orders of the enantiomers on both columns were examined. The thermodynamic parameters obtained from van't Hoff plots were all negative, which indicated that the chiral separation were enthalpically driven.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据