期刊
JOURNAL OF LIPOSOME RESEARCH
卷 22, 期 1, 页码 1-7出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/08982104.2011.573793
关键词
Drug delivery; liposomes; volatile oil; thermoanalysis; brain-cell viability
资金
- FAPESB [DCR0092/2005]
- CNPq
Zanthoxylum tinguassuiba essential oil (ZtEO) contains a-bisabolol, a known antiglioma sesquiterpene, among other potentially active substances. Medical applications of this essential oil require advances in the design of distinctive carriers due to its low water solubility and easy degradation by heat, light, and oxygen. The aim of this work was to evaluate enhancement in oxidative stability and the ability to reduce glioblastoma cell viability of ZtEO loaded into liposomes. Multi-and unilamellar vesicles were prepared to carry ZtEO. By using thermal analysis, it was observed that thermal-oxidative stability of the liposomal ZtEO was enhanced, when compared to its free form. Liposomal ZtEO also presented significant apoptotic-inducing activity for glioma cells. These results show that liposomal systems carrying ZtEO may be a potential alternative for gliobastoma treatment.
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