Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2

High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

(2014) E Gabandé-Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons

(2014) Nadine Beckmann et al.   Frontiers in Physiology

Sphingolipids and lysosomal pathologies

(2013) Heike Schulze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Endosomal/Lysosomal Processing of Gangliosides Affects Neuronal Cholesterol Sequestration in Niemann-Pick Disease Type C

(2011) Sharon Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Cathepsin B Overexpression Due to Acid Sphingomyelinase Ablation Promotes Liver Fibrosis in Niemann-Pick Disease

(2011) Anna Moles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosomal Lipid Storage Diseases

(2011) H. Schulze et al.   Cold Spring Harbor Perspectives in Biology

Transfer of Cholesterol by the NPC Team

(2010) Jean E. Vance   Cell Metabolism

A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation

(2010) Russell W. Jenkins et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion

(2010) Misbaudeen Abdul-Hammed et al.   JOURNAL OF LIPID RESEARCH

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Acid sphingomyelinase possesses a domain homologous to its activator proteins: Saposins B and D

(2010) Christopher P. Ponting   PROTEIN SCIENCE

Improvement in Lipid and Protein Trafficking in Niemann-Pick C1 Cells by Correction of a Secondary Enzyme Defect

(2010) Cecilia Devlin et al.   TRAFFIC

Mechanisms and consequences of impaired lipid trafficking in Niemann–Pick type C1-deficient mammalian cells

(2009) Barbara Karten et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Niemann–Pick C2 (NPC2) and intracellular cholesterol trafficking

(2009) Judith Storch et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol

(2009) Hyock Joo Kwon et al.   CELL

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Lysosomal degradation of membrane lipids

(2009) Thomas Kolter et al.   FEBS LETTERS

Saposin B-dependent Reconstitution of Arylsulfatase A Activityin Vitroand in Cell Culture Models of Metachromatic Leukodystrophy

(2009) Ulrich Matzner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of negatively charged lipids in lysosomal phospholipase A2 function

(2009) Akira Abe et al.   JOURNAL OF LIPID RESEARCH

Regulation of Sterol Transport between Membranes and NPC2†

(2008) Zhi Xu et al.   BIOCHEMISTRY

Secondary lipid accumulation in lysosomal disease

(2008) Steven U. Walkley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE