Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester

Loss of HDAC5 Impairs Memory Function: Implications for Alzheimer's Disease

(2018) Roberto Carlos Agis-Balboa et al.   JOURNAL OF ALZHEIMERS DISEASE

An Integrative View of the Role of Oxidative Stress, Mitochondria and Insulin in Alzheimer's Disease

(2017) Paula I. Moreira et al.   JOURNAL OF ALZHEIMERS DISEASE

Ketogenic diet in adolescents and adults with epilepsy

(2014) Maromi Nei et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Ketone body metabolism and cardiovascular disease

(2013) David G. Cotter et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Therapeutic ketosis with ketone ester delays central nervous system oxygen toxicity seizures in rats

(2013) Dominic P. D'Agostino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet

(2012) Shireesh Srivastava et al.   FASEB JOURNAL

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Ketone bodies in epilepsy

(2012) Melanie A. McNally et al.   JOURNAL OF NEUROCHEMISTRY

Preclinical sporadic Alzheimer's disease: target for personalized diagnosis and preventive intervention

(2012) Theodore B. VanItallie   METABOLISM-CLINICAL AND EXPERIMENTAL

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

Oral 28-day and developmental toxicity studies of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate

(2012) Kieran Clarke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Kinetics, safety and tolerability of (R)-3-hydroxybutyl (R)-3-hydroxybutyrate in healthy adult subjects

(2012) Kieran Clarke et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Simultaneous measurement of glucose transport and utilization in the human brain

(2011) Alexander A. Shestov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

(2011) D. F.F. Silva et al.   Current Alzheimer Research

The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms

(2011) Adam L. Numis et al.   EPILEPSY RESEARCH

Early dysregulation of the mitochondrial proteome in a mouse model of Alzheimer's disease

(2011) Jose L. Chou et al.   Journal of Proteomics

Role of β-hydroxybutyric acid in the central regulation of energy balance

(2010) Thomas Laeger et al.   APPETITE

Ketogenic diets: An historical antiepileptic therapy with promising potentialities for the aging brain

(2010) Marta Balietti et al.   AGEING RESEARCH REVIEWS

Infantile spasms treated with the ketogenic diet: Prospective single-center experience in 104 consecutive infants

(2010) Amanda M. Hong et al.   EPILEPSIA

A Ketone Ester Diet Increases Brain Malonyl-CoA and Uncoupling Proteins 4 and 5 while Decreasing Food Intake in the Normal Wistar Rat

(2010) Yoshihiro Kashiwaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain fuel metabolism, aging, and Alzheimer’s disease

(2010) Stephen Cunnane et al.   NUTRITION

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

PET study of 11C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis

(2009) M'hamed Bentourkia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease

(2009) Baohua Cheng et al.   BRAIN RESEARCH

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease

(2009) Hansruedi Büeler   EXPERIMENTAL NEUROLOGY

Altered Brain Mitochondrial Metabolism in Healthy Aging as Assessed by in vivo Magnetic Resonance Spectroscopy

(2009) Fawzi Boumezbeur et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ketogenic Diets: An Update for Child Neurologists

(2009) Eric H. Kossoff et al.   JOURNAL OF CHILD NEUROLOGY

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Hypometabolism as a therapeutic target in Alzheimer's disease

(2008) Lauren C Costantini et al.   BMC NEUROSCIENCE

Acetone as an Anticonvulsant

(2008) Sergei Likhodii et al.   EPILEPSIA

Ketosis and brain handling of glutamate, glutamine, and GABA

(2008) Marc Yudkoff et al.   EPILEPSIA

A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy

(2008) Elizabeth G. Neal et al.   EPILEPSIA

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

Parkinson disease: primacy of age as a risk factor for mitochondrial dysfunction

(2008) Theodore B. VanItallie   METABOLISM-CLINICAL AND EXPERIMENTAL

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Mechanisms of Aβ mediated neurodegeneration in Alzheimer's disease

(2007) Peter J. Crouch et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY