Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation

Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity

(2014) M. P. Sajan et al.   DIABETES

PKCλ Haploinsufficiency Prevents Diabetes by a Mechanism Involving Alterations in Hepatic Enzymes

(2014) Mini P. Sajan et al.   MOLECULAR ENDOCRINOLOGY

Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

(2013) Mini P. Sajan et al.   DIABETOLOGIA

Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors

(2012) M. P. Sajan et al.   DIABETOLOGIA

Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C–ι

(2012) Mini P. Sajan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Phosphorylation and Recruitment of BAF60c in Chromatin Remodeling for Lipogenesis in Response to Insulin

(2012) Yuhui Wang et al.   MOLECULAR CELL

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

(2010) Shijie Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased basal level of Akt-dependent insulin signaling may be responsible for the development of insulin resistance

(2009) Hui-Yu Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

(2009) Guang Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic functions of atypical protein kinase C: “good” and “bad” as defined by nutritional status

(2009) Robert V. Farese et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFκB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance

(2009) M. P. Sajan et al.   DIABETOLOGIA

The critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity

(2009) Mini P. Sajan et al.   JOURNAL OF LIPID RESEARCH

Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis

(2008) Thorsten Fritzius et al.   EMBO JOURNAL