Article
Chemistry, Multidisciplinary
Arnold E. Stuetz, Martin Thonhofer, Patrick Weber, Andreas Wolfsgruber, Tanja M. Wrodnigg
Summary: The article presents a brief survey on selected beta-galactosidase inhibitors as potential pharmacological chaperones for G(M1)-gangliosidosis and Morquio B associated mutants of human lysosomal beta-galactosidase, highlighting recent developments in this specific area of lysosomal storage disorders and orphan diseases.
Review
Energy & Fuels
Mohammad Nazmus Sakib, Saifuddin Ahmed, S. M. Sultan Mahmud Rahat, Sanzeeda Baig Shuchi
Summary: Manganese-based supercapacitors are gaining attention for their low manufacturing cost and environmental friendliness. By utilizing various surface modifications and structural changes, the performance of the supercapacitors can be enhanced.
JOURNAL OF ENERGY STORAGE
(2021)
Review
Medicine, Research & Experimental
Giancarlo Parenti, Diego L. Medina, Andrea Ballabio
Summary: Lysosomal storage diseases are metabolic disorders caused by deficiencies in lysosomal function components. Understanding of lysosomal biology has evolved from organelles involved in catabolic pathways to dynamic elements involved in multiple cellular functions and capable of adapting to environmental stimuli. Novel technologies based on high-throughput approaches have greatly contributed to the characterization of lysosomal biology and dysfunction.
EMBO MOLECULAR MEDICINE
(2021)
Review
Genetics & Heredity
Edward H. Schuchman, Maria D. Ledesma, Calogera M. Simonaro
Summary: In recent years, researchers have begun to focus on finding drugs that can be used for multiple lysosomal diseases to overcome the challenges in current treatment, with particular attention to common pathological mechanisms in the central nervous system.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Review
Plant Sciences
William Oyom, Yong-cai Li, Dov Prusky, Zhong Zhang, Yang Bi, Reza Tahergorabi
Summary: The postharvest storability of Asia pears is challenged by fungi infections, leading to spoilage diseases and economic losses. Chemical fumigation has been effective but limited by environmental impact and resistant strains. Non-chemical treatments like hot water dip and biological control have shown effectiveness in slowing microbial growth, while emerging techniques such as edible coatings and gaseous ozone have potential but require further optimization.
PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY
(2022)
Review
Chemistry, Physical
N. A. Sazelee, M. Ismail
Summary: LiAlH4 is considered a potential material for solid-state hydrogen storage due to its high hydrogen content, but challenges like high decomposition temperature and slow dehydrogenation hinder its wider applications. Methods such as mechanical milling and catalyst doping have shown improvements in efficiency, but further technological advancements are needed to meet expected goals.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Review
Materials Science, Multidisciplinary
Huai-Jun Lin, Yan-Shan Lu, Liu-Ting Zhang, Hai-Zhen Liu, Kaveh Edalati, Adam Revesz
Summary: In this review, recent advances in the study of metastable alloys for hydrogen storage applications are comprehensively reviewed. The synthesis methods and hydrogen storage properties of metastable alloys are summarized and discussed, highlighting their unique kinetics and thermodynamics properties. For example, Mg-based amorphous and nanoglass alloys exhibit superior hydrogenation kinetics and higher hydrogen storage capacity, while the immiscible Mg-Mn and Mg-Zr alloys show destabilized thermodynamics properties.
Article
Biochemistry & Molecular Biology
Claudia Rossi, Rossella Ferrante, Silvia Valentinuzzi, Mirco Zucchelli, Carlotta Buccolini, Sara Di Rado, Daniela Trotta, Liborio Stuppia, Luca Federici, Maurizio Arico
Summary: Gaucher disease is a lysosomal storage disease caused by a deficiency in lysosomal glucocerebrosidase, leading to the accumulation of glucosylceramide in various organs. Early detection and intervention are crucial for improving clinical outcomes.
Review
Peripheral Vascular Disease
Austin H. Hu, Tara I. Chang
Summary: Intensive blood pressure lowering significantly reduces cardiovascular events and all-cause mortality in patients with chronic kidney disease, and may also lower the risk of probable dementia. However, the effects on kidney disease progression are inconclusive and more studies are needed to evaluate long-term impacts. Additionally, there is a risk of incident chronic kidney disease and acute kidney injury with intensive blood pressure therapy, but declines in kidney function seem to be reversible and driven by hemodynamics.
Review
Biology
Shahzaib Iqbal, Tariq M. Khan, Khuram Naveed, Syed S. Naqvi, Syed Junaid Nawaz
Summary: Automated retinal image analysis is crucial for accurately diagnosing various critical eye diseases. This paper provides an extensive review of state-of-the-art methods for detecting and segmenting retinal image features, as well as summarizing performance measures for different stages of retinal image analysis. The significance of commonly used datasets for analyzing retinal images is also emphasized.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Physical
Hae Woong Park, Kwang Chul Roh
Summary: This review summarizes the application of pseudocapacitive materials as electrode materials for supercapacitors in energy-storage systems. The origin, historical development, and basic principles of pseudocapacitive materials are first summarized, followed by synthesis strategies to improve their electrochemical performance. The latest advances in advanced electrode materials with high-energy densities are then highlighted, and the major challenges and prospective directions for developing pseudocapacitive materials for supercapacitors are discussed.
JOURNAL OF POWER SOURCES
(2023)
Review
Pharmacology & Pharmacy
Debora Collotta, Maria Paola Franchina, Virginia Carlucci, Massimo Collino
Summary: With the global epidemic, metabolic syndrome has become an emerging risk and is recognized as a pathological entity. Efforts to promote healthier lifestyles have not been successful in reducing the incidence and prevalence of metabolic syndrome worldwide. Recent research has shown that the JAK/STAT pathway plays a significant role in chronic inflammatory conditions like obesity, suggesting that JAK inhibitors could be a potential therapeutic option for metabolic diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Genetics & Heredity
Neel S. Iyer, Alexis C. Gimovsky, Carlos R. Ferreira, Elizabeth Critchlow, Huda B. Al-Kouatly
Summary: This study found that the incidence of lysosomal storage disorders in cases of nonimmune hydrops fetalis was 6.6% overall and 8.2% in idiopathic cases. The most common LSDs identified were mucopolysaccharidosis type VII, galactosialidosis, infantile sialic acid storage disease, Gaucher disease, GM1 gangliosidosis, and sialidosis. Over 40% of these LSDs have potential postnatal treatment options, highlighting the importance of early diagnosis and appropriate management.
Review
Biochemistry & Molecular Biology
Daniela Vuolo, Cinthia Castro Do Nascimento, Vania D'Almeida
Summary: Lysosomal storage diseases (LSDs) are complex multisystemic diseases caused by gene mutations, affecting reproductive parameters in animal models. The use of more female animal models and clinical case studies are suggested to better understand the pathophysiology of these diseases and explore the risks associated with individuals with LSDs having children.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Energy & Fuels
Yongliang Shen, Abdur Rehman Mazhar, Shuli Liu
Summary: This study reviewed literature on cascaded latent heat storage (CLHS) technology to analyze the research progress, challenges, and future directions. The results showed that the thermal advantages of CLHS can be further enhanced by optimizing the structure of the heat storage unit and the physical properties of the phase change material (PCM). The main challenges of this technology are the selection, development, and distribution of PCMs. Future research should focus on developing more accurate intelligent optimization algorithms and dynamic models, as well as studying practical applications in low-temperature thermal energy storage and cold storage.
JOURNAL OF ENERGY STORAGE
(2022)