ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK

Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype

(2014) D. Sag et al.   JOURNAL OF IMMUNOLOGY

Lymphocyte-suppressing and systemic anti-inflammatory effects of high-dose metformin in simvastatin-treated patients with impaired fasting glucose

(2012) Robert Krysiak et al.   ATHEROSCLEROSIS

A Genome-Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex

(2012) Robert W. Davies et al.   Circulation-Cardiovascular Genetics

MT1-MMP regulates the PI3K {middle dot}Mi-2/NuRD-dependent control of macrophage immune function

(2012) R. Shimizu-Hirota et al.   GENES & DEVELOPMENT

LKB1 and AMPK: central regulators of lymphocyte metabolism and function

(2012) Julianna Blagih et al.   IMMUNOLOGICAL REVIEWS

AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity

(2012) Joo-Won Lee et al.   JOURNAL OF LIPID RESEARCH

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

(2012) Stephen L. Pinkosky et al.   JOURNAL OF LIPID RESEARCH

AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases

(2012) Rai Ajit K. Srivastava et al.   JOURNAL OF LIPID RESEARCH

ETC-1002 LOWERS LDL-C AND BENEFICIALLY MODULATES OTHER CARDIO-METABOLIC RISK FACTORS IN HYPERCHOLESTEROLEMIC SUBJECTS WITH EITHER NORMAL OR ELEVATED TRIGLYCERIDES

(2012) Christie M. Ballantyne et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The effect of metformin on monocyte secretory function in simvastatin-treated patients with impaired fasting glucose

(2012) Robert Krysiak et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Chemokines: established and novel targets in atherosclerosis

(2011) Rory R. Koenen et al.   EMBO Molecular Medicine

The role of LKB1 and AMPK in cellular responses to stress and damage

(2011) Angela Alexander et al.   FEBS LETTERS

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

(2011) Sandra Galic et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation

(2011) Christian D. Sadik et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Anti-inflammatory therapeutics for the treatment of atherosclerosis

(2011) Israel F. Charo et al.   NATURE REVIEWS DRUG DISCOVERY

Levels of sCD40 Ligand in Chronic and Acute Coronary Syndromes and its Relation to Angiographic Extent of Coronary Arterial Narrowing

(2010) Hanan H. Fouad et al.   ANGIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis

(2010) Aiping Bai et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic Approaches to Target Inflammation in Type 2 Diabetes

(2010) A. B. Goldfine et al.   CLINICAL CHEMISTRY

Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1

(2010) Zhenggang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement in atherosclerosis: friend or foe?

(2010) W. S. SPEIDL et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

C-Reactive Protein, Statins, and Cardiovascular Risk: What Can JUPITER Teach Us?

(2009) Adam M. Rogers et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chemokines in the vascular inflammatory response of atherosclerosis

(2009) A. Zernecke et al.   CARDIOVASCULAR RESEARCH

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein

(2009) James K. Liao   Current Atherosclerosis Reports

Obesity, inflammation, and atherosclerosis

(2009) Viviane Z. Rocha et al.   Nature Reviews Cardiology

IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat

(2009) J. A. Ehses et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury

(2008) Xia Zhao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Breaching the basement membrane: who, when and how?

(2008) R. Grant Rowe et al.   TRENDS IN CELL BIOLOGY