Article
Biochemistry & Molecular Biology
Beatrix Paton, Elisabet Foguet-Romero, Manuel Suarez, Jordi Mayneris-Perxachs, Noemi Boque, Antoni Caimari, Nuria Canela, Pol Herrero
Summary: The consumption of diets rich in saturated fats is associated with higher mortality. Adopting healthy habits, such as adhering to a Mediterranean diet, has been shown to have a preventive effect on cardiovascular diseases and dyslipidemia. However, the effects of an suboptimal diet on brain function and structure are still poorly understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Xianlin Han, Hongping Ye
Summary: Although triglycerides play important roles in cellular growth, metabolism, and function, accurately identifying their molecular species and quantities remains a challenge.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Analytical
David S. Gertner, Jake P. Violi, David P. Bishop, Matthew P. Padula
Summary: Due to the complexity of lipids, in silico generated spectral libraries have become crucial for identifying lipid species in mass spectral data. However, many existing libraries have limitations in usability and representativeness. To address this issue, we introduce Lipid Spectrum Generator, an open-source tool specifically designed for aiding lipid identification in liquid chromatography-tandem mass spectrometry analysis.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Jen Lin, Pei-Chun Shen, Hsiu-Cheng Liu, Yi-Chun Cho, Min-Kung Hsu, I-Chen Lin, Fang-Hsin Chen, Juan-Cheng Yang, Wen-Lung Ma, Wei-Chung Cheng
Summary: LipidSig is a flexible and user-friendly web server designed to help users identify significant lipid-related features and advance the field of lipid biology through efficient data analysis and exploration of lipid characteristics.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemical Research Methods
Tyler S. Larson, Thomas J. Diprospero, Gary L. Glish, Matthew R. Lockett
Summary: In this study, a novel method was used to investigate the lipid profile changes in oxaliplatin-sensitive and resistant cells, revealing significant increases in triglycerides and cholesterol esters caused by oxaliplatin, which were correlated with lipid droplet formation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jing Kai Chang, Guoshou Teo, Yael Pewzner-Jung, Daniel J. Cuthbertson, Anthony H. Futerman, Markus R. Wenk, Hyungwon Choi, Federico Torta
Summary: In this study, an untargeted lipidomics workflow using Q-RAI DIA approach was proposed, which enables simultaneous identification and reproducible relative quantification of lipids. This method was validated using lipid extracts from human plasma and serum samples from CerS2 null mice, and several lipid species significantly different between groups were identified.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Martin Ho Yin Yeung, Ka Long Leung, Lai Yuen Choi, Jung Sun Yoo, Susan Yung, Pui-Kin So, Chi-Ming Wong
Summary: This study used lipidomic analysis to reveal the changes in lipid composition and distribution in the kidneys of high-fat diet-fed mice after treatment with the long-acting GLP-1RA dulaglutide. The results showed that dulaglutide treatment increased the level of cardiolipin, an essential phospholipid constituent of inner mitochondrial membrane, at the cortex region of the kidneys, which stimulated mitochondrial bioenergetics. This provides new insights into the therapeutic potential of GLP-1RAs in mitochondrial-related diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Jessica Medina, Rebecca Borreggine, Tony Teav, Liang Gao, Shanshan Ji, Justin Carrard, Christina Jones, Niek Blomberg, Martin Jech, Alan Atkins, Claudia Martins, Arno Schmidt-Trucksass, Martin Giera, Amaury Cazenave-Gassiot, Hector Gallart-Ayala, Julijana Ivanisevic
Summary: This study presents a targeted LC-MS/MS approach for high-throughput quantification of complex lipid species. The method achieved high precision measurements within and across multiple batches. The method can distinguish between different sample sources and reveal sex-specific differences in the serum lipidome.
ANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Beatriz Quintanilla-Casas, Giulia Strocchi, Julen Bustamante, Berta Torres-Cobos, Francesc Guardiola, Wenceslao Moreda, Jose Manuel Martinez-Rivas, Enrico Valli, Alessandra Bendini, Tullia Gallina Toschi, Alba Tres, Stefania Vichi
Summary: The study developed an authentication model based on TAG profiling for the detection of illegal blends of various vegetable oils with olive oil. The model proved to be efficient and applicable, with high accuracy in classifying mixed samples and an overall correct classification rate.
Article
Nutrition & Dietetics
Dadi Xie, Yanbo Zhang, Yujin Guo, Xianzhong Xue, Shiyuan Zhao, Chunmei Geng, Yuanyuan Li, Rui Yang, Yizhang Gan, Hanbing Li, Zhongfa Ren, Pei Jiang
Summary: The objective of this research was to observe and evaluate the impact of dietary components on metabolomic profiles in primary tissues of mice. The levels of metabolites in mice were studied and analyzed using gas chromatography-mass spectrometry. The results showed significant differences in metabolites related to energy, amino acids, and lipid metabolism.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Sylwia A. Stopka, Jiska van der Reest, Walid M. Abdelmoula, Daniela F. Ruiz, Shakchhi Joshi, Alison E. Ringel, Marcia C. Haigis, Nathalie Y. R. Agar
Summary: Cells adapt their metabolism in response to physiological cues, and metabolic heterogeneity exists at various levels. The liver plays a crucial role in maintaining overall metabolic balance, and its structure is defined by metabolic zones. Mass spectrometry imaging enables the mapping of metabolites directly from tissue sections, allowing for a better understanding of metabolic heterogeneity compared to traditional methods. This study establishes a workflow for matrix-assisted laser desorption/ionization mass spectrometry imaging and provides insights into liver metabolism under nutrient stress and excess.
Article
Biochemical Research Methods
Isin T. Sakallioglu, Amith S. Maroli, Aline De Lima Leite, Robert Powers
Summary: This study introduces a rapid reversed-phase ultra-high-performance liquid chromatography-high resolution mass spectrometry method for mycobacterial lipidomics analysis, which achieves separation of various lipid classes specific to mycobacterium in a short runtime of 14 minutes. The method demonstrates high sensitivity and faster sample throughput compared to existing methods.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemistry & Molecular Biology
Qiaoyu Li, Yuqi Lin, Jinlin Xu, Yukun Liu, Yuxuan Jing, Rongzeng Huang, Chengwu Song, Lijun Zhang, Shuna Jin
Summary: Diet restriction (DR) can ameliorate obesity by regulating mitochondrial function. This study evaluated the effects of graded levels of DR on obesity based on mitochondrial CL levels in the liver. The results showed significant improvements in the liver after DR, except for the 60 DR group.
Review
Spectroscopy
Thomas Zuellig, Harald C. Koefeler
Summary: The rapid growth of lipidomics research in the past decade is closely linked to advancements in mass spectrometry instrumentation. The shift from low resolution to high-resolution lipidomics platforms is a key trend in the field.
MASS SPECTROMETRY REVIEWS
(2021)
Article
Chemistry, Analytical
Kelly L. Wormwood Moser, Gregory Van Aken, Daniel DeBord, Nathan Galen Hatcher, Laura Maxon, Melissa Sherman, Lihang Yao, Kim Ekroos
Summary: Defects in sphingolipid metabolism serve as a common link in various neurodegenerative disorders, and a better understanding of lipid content presents opportunities for the development of new therapeutic targets and biomarkers.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Jun Hayakawa, Miao Wang, Chunyan Wang, Rowland H. Han, Zhen Y. Jiang, Xianlin Han
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2018)
Article
Clinical Neurology
Rowland H. Han, Andrew McKinnon, Travis S. CreveCoeur, Brandon S. Baksh, Amit M. Mathur, Christopher D. Smyser, Jennifer M. Strahle, Margaret A. Olsen, David D. Limbrick
CHILDS NERVOUS SYSTEM
(2018)
Article
Clinical Neurology
Brandon S. Baksh, Namita Sinha, Afshin Salehi, Rowland H. Han, Brandon A. Miller, Sonika Dahiya, Karen M. Gauvain, David D. Limbrick
WORLD NEUROSURGERY
(2018)
Article
Pediatrics
Rachel E. Lean, Rowland H. Han, Tara A. Smyser, Jeanette K. Kenley, Joshua S. Shimony, Cynthia E. Rogers, David D. Limbrick, Christopher D. Smyser
PEDIATRIC RESEARCH
(2019)
Article
Oncology
Zezhong Ye, Richard L. Price, Xiran Liu, Joshua Lin, Qingsong Yang, Peng Sun, Anthony T. Wu, Liang Wang, Rowland H. Han, Chunyu Song, Ruimeng Yang, Sam E. Gary, Diane D. Mao, Michael Wallendorf, Jian L. Campian, Jr-Shin Li, Sonika Dahiya, Albert H. Kim, Sheng-Kwei Song
CLINICAL CANCER RESEARCH
(2020)
Article
Clinical Neurology
Diego M. Morales, Christopher D. Smyser, Rowland H. Han, Jeanette K. Kenley, Joshua S. Shimony, Tara A. Smyser, Jennifer M. Strahle, Terrie E. Inder, David D. Limbrick
Summary: The study examined the relationship between diffusion magnetic resonance imaging (dMRI) and cerebrospinal fluid (CSF) biomarkers in preterm infants with posthemorrhagic hydrocephalus (PHH), finding elevated CSF biomarkers and differences in dMRI measures between PHH infants and controls. Specific associations were observed between dMRI and CSF biomarkers at the initiation of PHH treatment, suggesting potential for innovative methods to examine PHH-related white matter injury and developmental sequelae.
Article
Clinical Neurology
Syed Hassan A. Akbari, Asad A. Rizvi, Travis S. CreveCoeur, Rowland H. Han, Jacob K. Greenberg, James Torner, Douglas L. Brockmeyer, John C. Wellons, Jeffrey R. Leonard, Francesco T. Mangano, James M. Johnston, Manish N. Shah, Bermans J. Iskandar, Raheel Ahmed, Gerald F. Tuite, Bruce A. Kaufman, David J. Daniels, Eric M. Jackson, Gerald A. Grant, Alexander K. Powers, Daniel E. Couture, P. David Adelson, Tord D. Alden, Philipp R. Aldana, Richard C. E. Anderson, Nathan R. Selden, Karin Bierbrauer, William Boydston, Joshua J. Chern, William E. Whitehead, Robert C. Dauser, Richard G. Ellenbogen, Jeffrey G. Ojemann, Herbert E. Fuchs, Daniel J. Guillaume, Todd C. Hankinson, Brent R. O'Neill, Mark Iantosca, W. Jerry Oakes, Robert F. Keating, Paul Klimo, Michael S. Muhlbauer, J. Gordon McComb, Arnold H. Menezes, Nickalus R. Khan, Toba N. Niazi, John Ragheb, Chevis N. Shannon, Jodi L. Smith, Laurie L. Ackerman, Andrew H. Jea, Cormac O. Maher, Prithvi Narayan, Gregory W. Albert, Scellig S. D. Stone, Lissa C. Baird, Naina L. Gross, Susan R. Durham, Stephanie Greene, Robert C. McKinstry, Joshua S. Shimony, Jennifer M. Strahle, Matthew D. Smyth, Ralph G. Dacey, Tae Sung Park, David D. Limbrick
Summary: This study aimed to assess the social determinants influencing access and outcomes for pediatric neurosurgical care for patients with Chiari malformation type I and syringomyelia. The research found that race, ethnicity, and insurance status influenced the presentation and management of these patients, with non-White patients presenting at an older age, showing certain neurological deficits, and being more likely to be treated at low-volume centers. Additionally, insurance status also impacted the timing of surgery and treatment processes for the patients.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Rui Sun, Rowland Han, Colin McCornack, Saad Khan, G. Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M. Schoch, Diane D. Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin Luo, Allegra Petti, Timothy M. Miller, Jason D. Ulrich, David M. Holtzman, Albert H. Kim
Summary: This study found that TREM2 is highly expressed in myeloid subsets in human and mouse GBM tumors and is associated with poor prognosis. Loss of TREM2 function leads to increased immunoactivation, proinflammatory polarization, and tumoricidal capacity in myeloid cells. Inhibition of TREM2 reprograms myeloid phenotypes and enhances the effectiveness of anti-PD-1 treatment in GBM.
Article
Oncology
Rowland H. Han, Tanner M. Johanns, Kaleigh F. Roberts, Yu Tao, Jingqin Luo, Zezhong Ye, Peng Sun, Jacob Blum, Tsen-Hsuan Lin, Sheng-Kwei Song, Albert H. Kim
Summary: In this study, we investigated the use of DBSI hindered fraction in distinguishing treatment changes from tumor progression in high-grade glioma patients after chemoradiotherapy. We found that DBSI hindered fraction is elevated in cases of treatment effect, suggesting its potential as a valuable adjunct to conventional MRI for diagnosis.
NEURO-ONCOLOGY ADVANCES
(2023)
Review
Oncology
Gabrielle W. Johnson, Rowland H. Han, Matthew D. Smyth, Eric C. Leuthardt, Albert H. Kim
Summary: LITT is an effective treatment option for patients with IDH1/2 mutant glioma, as suggested by the outcomes of this study.
Article
Multidisciplinary Sciences
Albert M. Isaacs, Rowland H. Han, Christopher D. Smyser, David D. Limbrick, Joshua S. Shimony
Article
Neuroimaging
Albert M. Isaacs, Christopher D. Smyser, Rachel E. Lean, Dimitrios Alexopoulos, Rowland H. Han, Jeffrey J. Neil, Sophia A. Zimbalist, Cynthia E. Rogers, Yan Yan, Joshua S. Shimony, David D. Limbrick
NEUROIMAGE-CLINICAL
(2019)
Article
Clinical Neurology
Rory K. Murphy, Peng Sun, Rowland H. Han, Kim J. Griffin, Joanne Wagner, Chester K. Yarbrough, Neill M. Wright, Ian G. Dorward, K. Daniel Riew, Michael P. Kelly, Paul Santiago, Lukas P. Zebala, Kathryn Trinkaus, Wilson Z. Ray, Sheng-Kwei Song
JOURNAL OF NEUROSURGICAL SCIENCES
(2018)
Article
Neurosciences
Gakwaya Habiyaremye, Diego M. Morales, Clinton D. Morgan, James P. McAllister, Travis S. CreveCoeur, Rowland H. Han, Mohamed Gabir, Brandon Baksh, Deanna Mercer, David D. Limbrick
FLUIDS AND BARRIERS OF THE CNS
(2017)
Article
Clinical Neurology
Rowland H. Han, Daniel Berger, Mohamed Gabir, Brandon S. Baksh, Diego M. Morales, Amit M. Mathur, Christopher D. Smyser, Jennifer M. Strahle, David D. Limbrick
CHILDS NERVOUS SYSTEM
(2017)