Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24

Severe hepatocellular disease in mice lacking one or bothCaaXprenyltransferases

(2011) Shao H. Yang et al.   JOURNAL OF LIPID RESEARCH

Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes

(2010) Roger Lee et al.   HUMAN MOLECULAR GENETICS

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria

(2010) B. S. J. Davies et al.   HUMAN MOLECULAR GENETICS

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson–Gilford progeria syndrome, with antisense oligonucleotides

(2009) Loren G. Fong et al.   HUMAN MOLECULAR GENETICS

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria

(2009) Shao H. Yang et al.   JOURNAL OF LIPID RESEARCH

HIV-protease inhibitors block the enzymatic activity of purified Ste24p

(2008) Sarah E. Hudon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells

(2008) Catherine Coffinier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated

(2008) Shao H. Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE