Article
Plant Sciences
Muhammad Ibrar Khan, Zarnishal Kainat, Saman Maqbool, Ambreen Mehwish, Suhaib Ahmad, Hafiz Muhammad Suleman, Zahid Mahmood, Mohsin Ali, Abdul Aziz, Awais Rasheed, Huihui Li
Summary: Increasing global temperature negatively affects crop growth and yield, especially at the seedling stage. This study characterized wheat cultivars in Pakistan under high temperature stress and identified loci associated with heat tolerance. The research identified specific haplotypes and quantitative trait nucleotides (QTNs) linked to heat tolerance. These findings can guide breeding efforts to develop heat-tolerant wheat varieties.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Fisheries
Jose M. Yanez, Agustin Barria, Maria E. Lopez, Thomas Moen, Baltasar F. Garcia, Grazyella M. Yoshida, Peng Xu
Summary: Advancements in genomic technologies have played a crucial role in the genetic improvement of aquaculture species through the discovery and application of DNA-markers, such as SNPs. Specific genomic regions associated with economically important traits have been identified using GWAS, allowing the incorporation of markers linked to QTL into aquaculture breeding programs through MAS. However, most economically relevant traits are controlled by multiple QTLs, each explaining only a small portion of the genetic variation.
REVIEWS IN AQUACULTURE
(2023)
Article
Horticulture
QiuXia C. Chen, Ryan M. Warner
Summary: The field performance of herbaceous annual plants is influenced by plant architecture and flowering performance. A study was conducted on a Petunia hybrid population in four field environments in the United States to analyze seven plant habit and flowering-related traits. Robust QTLs were identified for most traits and they were distributed across the Petunia chromosomes. These QTLs explained a substantial proportion of the observed phenotypic variation for most traits.
Article
Fisheries
Mijuan Shi, Hongrui Luo, Wanting Zhang, Yinjun Jiang, Ji Chen, Yingyin Cheng, Wei Hu, Xiao-Qin Xia
Summary: The rice-field eel has increasing economic value as a freshwater aquaculture fish in Asia, and genetic breeding research is needed to ensure fry supply for production. A genome-wide linkage analysis and high-density linkage map construction identified growth-related genes and quantitative trait loci, providing guidance for high-yield breeding. The study also successfully mounted supercontigs to chromosomes, showing good collinearity with the draft genome and identifying candidate growth-related genes for further investigation.
Article
Plant Sciences
Yuliya Genievskaya, Nicola Pecchioni, Giovanni Laido, Shynar Anuarbek, Aralbek Rsaliyev, Vladimir Chudinov, Alibek Zatybekov, Yerlan Turuspekov, Saule Abugalieva
Summary: By conducting a genome-wide association study, this research identified quantitative trait loci (QTLs) associated with resistance to leaf rust (LR) and stem rust (SR) in tetraploid wheat. These QTLs can potentially be used for marker-assisted selection of wheat varieties resistant to LR and SR.
Article
Plant Sciences
Xujiang Wu, Junchan Wang, Di Wu, Wei Jiang, Zhifu Gao, Dongsheng Li, Rongling Wu, Derong Gao, Yong Zhang
Summary: A genome-wide association study of sharp eyespot resistance in 262 wheat varieties from all China wheat regions identified two QTLs and 5 significantly related SNP loci. Results showed that only 6.5% of the varieties were resistant to sharp eyespot, with varieties from the middle and lower Yangtze River exhibiting higher resistance than those from Huanghuai wheat zone.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Xiaohui Song, Guozhong Zhu, Sen Hou, Yamei Ren, Muhammad Waqas Amjid, Weixi Li, Wangzhen Guo
Summary: Genome-wide association analysis was conducted on fiber quality parameters in cotton, identifying 67 stable quantitative trait loci (QTLs) related to fiber length, strength, and micronaire. Transcriptome analysis revealed candidate genes involved in crucial processes like sugar metabolism and cytoskeleton organization, providing new insights for improving fiber quality in cotton.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
L. Qu, M. M. Shen, T. C. Dou, M. Ma, J. Lu, X. G. Wang, J. Guo, Y. P. Hu, Y. F. Li, K. H. Wang
Summary: A study on the genetic architecture underlying mottled egg trait in layer chickens used genome-wide association studies, revealing significant loci influencing mottled egg on laying day, as well as candidate genes associated with mottled eggshell. The research suggests that genomic selection could be a profitable method for breeding out the mottled egg trait in hens.
Article
Agronomy
Rahele Panhabadi, Asadollah Ahmadikhah, Naser Farrokhi, Nadali Bagheri
Summary: This study conducted a genome-wide association study (GWAS) to identify genetic regions and candidate genes associated with seed germination and post-germination related seedling traits in rice. The results revealed several significant quantitative trait loci (QTLs) and candidate genes that play a role in regulating these traits.
Article
Biochemistry & Molecular Biology
Haijiao Wang, Hongliang Liu, Lingling Zhao, Sheng Luo, Tomi Akinyemiju, Shelley Hwang, Ying Yue, Qingyi Wei
Summary: This study suggests that genetic variants in FOXO pathway genes are associated with breast cancer risk, with five SNPs found to be significantly related to BC risk. These genetic variants may serve as new biomarkers for BC risk once replicated by other researchers.
MOLECULAR CARCINOGENESIS
(2021)
Article
Genetics & Heredity
Richard Habimana, Kiplangat Ngeno, Tobias Otieno Okeno, Claire D' Andre Hirwa, Christian Keambou Tiambo, Nasser Kouadio Yao
Summary: This study identified SNPs and genes associated with body weight and antibody response to Newcastle disease in Rwanda indigenous chickens, providing potential markers for genetic improvement in growth performance and disease resistance.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Richard Habimana, Kiplangat Ngeno, Tobias Otieno Okeno, Claire D'andre Hirwa, Christian Keambou Tiambo, Nasser Kouadio Yao
Summary: This study identified key genes and single nucleotide polymorphisms (SNPs) affecting body weight and antibody response to Newcastle disease in Rwanda indigenous chickens through genome-wide association studies. The results suggest promising genes and SNP-based markers that can be utilized for improving growth performance and disease resistance in indigenous chicken populations.
FRONTIERS IN GENETICS
(2021)
Article
Biology
Mahdi Moradi Marjaneh, Edwin P. Kirk, Ralph Patrick, Dimuthu Alankarage, David T. Humphreys, Gonzalo Del Monte-Nieto, Paola Cornejo-Paramo, Vaibhao Janbandhu, Tram B. Doan, Sally L. Dunwoodie, Emily S. Wong, Chris Moran, Ian C. A. Martin, Peter C. Thomson, Richard P. Harvey
Summary: Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely to be emergent phenomena arising from multilayer, multiscale, and highly interconnected interactions. This study provides the first high-resolution picture of genetic complexity and network liability underlying common congenital heart disease, with relevance to human ASD and PFO.
Article
Genetics & Heredity
Jose Luis Zepeda-Batista, Rafael Nunez-Dominguez, Rodolfo Ramirez-Valverde, Francisco Joel Jahuey-Martinez, Jessica Beatriz Herrera-Ojeda, Gaspar Manuel Parra-Bracamonte
Summary: This study utilized a GWAS to elucidate the genetic architecture of growth traits in Braunvieh cattle, identifying new QTL associated with liveweight traits and potential candidate genes related to embryonic cleavage, bone and tissue growth. The study also highlighted the importance of genes such as MCM2, TPRA1, GALM, and NRG1 in relation to growth-related traits.
Article
Evolutionary Biology
Emily Koot, Chen Wu, Igor Ruza, Elena Hilario, Roy Storey, Richard Wells, David Chagne, Maren Wellenreuther
Summary: Assessment of genetic structuring is crucial for management and conservation, as shown in a comprehensive genomic analysis of hoki revealing two distinct genetic clusters and limited genetic exchange between Australia and New Zealand. Putative adaptive SNPs did not further partition the dataset.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Cai Chen, Yao Zheng, Mengli Wang, Eduard Murani, Enrico D'Alessandro, Ali Shoaib Moawad, Xiaoyan Wang, Klaus Wimmers, Chengyi Song
Summary: Retrotransposon insertion polymorphisms (RIPs) play a significant role in the genetic variation of GH/IGF axis genes, with one SINE RIP in the intron 1 of GHR potentially acting as a repressor to decrease GHR expression.
Article
Microbiology
Henry Reyer, Per J. R. Sjoberg, Michael Oster, Aisanjiang Wubuli, Eduard Murani, Siriluck Ponsuksili, Petra Wolf, Klaus Wimmers
Summary: The manipulation of intestinal microbiota through feeding measures offers possibilities for optimizing the utilization of intestinal phytate and phosphorus, which is essential for proper growth processes and bone stability in pigs in livestock farming.
Correction
Genetics & Heredity
Asghar Ali, Eduard Murani, Frieder Hadlich, Xuan Liu, Klaus Wimmers, Siriluck Ponsuksili
Article
Cell Biology
Julia Brenmoehl, Christina Walz, Caroline Caffier, Elli Brosig, Michael Walz, Daniela Ohde, Nares Trakooljul, Martina Langhammer, Siriluck Ponsuksili, Klaus Wimmers, Uwe K. Zettl, Andreas Hoeflich
Summary: The study investigated the regulation of the GH/IGF system in physical performance using a mouse model selected for high running performance. Results showed coordinated downregulation of the somatotropic pathway and a lack of mTORC1 and mTORC2 activation in marathon mice in response to exercise. Additionally, the study found enhanced expression of certain genes related to endurance exercise in the muscle of the selected marathon mouse model.
Article
Agronomy
Dario Fornara, Elizabeth M. E. Ball, Christina Mulvenna, Henry Reyer, Michael Oster, Klaus Wimmers, Hanne Damgaard Poulsen, Arno Rosemarin
Summary: The over-supplementation of animal feeds with phosphorus leads to high rates of P excretion and negative environmental impacts. Adding phytase to pig and poultry diets can reduce P excretion, but the effects on plant-soil systems are poorly understood. This study found that phytase supplementation significantly influenced P content of animal waste and plant P dynamics, with intermediate phytase levels contributing to higher P use efficiency and lower soil P availability. The effects of dietary P content on P losses from soils varied depending on the type of organic amendment.
Article
Agriculture, Dairy & Animal Science
Christina C. Mulvenna, Ursula M. McCormack, Elizabeth Magowan, John McKillen, Mike R. Bedford, Carrie L. Walk, Michael Oster, Henry Reyer, Klaus Wimmers, Dario A. Fornara, M. Elizabeth E. Ball
Summary: Phytase has been a common addition to poultry diets for over 20 years, showing benefits in growth performance, nutrient digestibility, and bone parameters. This study found that superdosing phytase in rapeseed meal and maize dried distiller grains with solubles diets can improve performance, increase digestibility, and reduce P excretion by 15% compared to birds without phytase.
Article
Biochemistry & Molecular Biology
Maruf Hasan, Michael Oster, Henry Reyer, Siriluck Ponsuksili, Eduard Murani, Petra Wolf, Dagmar-Christiane Fischer, Klaus Wimmers
Summary: This study investigated the tissue-wide expression patterns of key genes related to vitamin D metabolism and FGF23 signaling in pigs fed different phosphorus diets. The results showed that non-renal tissues and cells have specific requirements for active vitamin D formation. Low phosphorus diet suppressed vitamin D signaling locally, while high phosphorus diet stimulated local vitamin D synthesis and regulation of FGF23 signaling in bone.
Article
Agriculture, Dairy & Animal Science
Adewunmi O. Omotoso, Henry Reyer, Michael Oster, Steffen Maak, Siriluck Ponsuksili, Klaus Wimmers
Summary: Phosphorus inclusion in broiler diets needs to be tailored to their physiological demands at different developmental stages. A timed nutritional conditioning strategy, such as P depletion, may enhance mineral homeostasis mechanisms and reduce dietary P supply. This study investigated the effects of dietary P depletion on broiler chickens at different developmental stages, revealing marked responses early on, but indications of compensatory mechanisms later. Endocrine control mediated by calcitriol, intestinal P uptake, and mineral mobilization from bones were identified as potential mechanisms for maintaining mineral homeostasis. Precise timing, duration, and extent of P depletion should be considered for optimized nutrient utilization in broiler husbandry.
Article
Chemistry, Analytical
Mohd. Rahil Hasan, Pradakshina Sharma, Shifa Shaikh, Saumitra Singh, Roberto Pilloton, Jagriti Narang
Summary: We have developed a paper-based experimental platform for analyzing dengue virus, which incorporates screen-printing technology and black carbon conductive ink. The platform utilizes both two-electrode and three-electrode systems, with an LOD of 0.1 μg/mL for detecting the virus. The three-electrode system exhibits a significantly higher current range and amplification compared to the two-electrode system, making it a viable option for sensitive detection of dengue virus and other diseases.
Article
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
Summary: Vitamin D-3 (Vit D-3) and 25(OH)D-3 are used as dietary sources of active vitamin D in pig husbandry, and while their primary effects are on the intestine, kidney, and bone, they also have wide-ranging effects on peripheral tissues. The use of Vit D-3 and 25(OH)D-3 in pig nutrition has been shown to have different outcomes in terms of reproductive capacities, growth performance, immunity, and bone development.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Nutrition & Dietetics
Maruf Hasan, Michael Oster, Henry Reyer, Klaus Wimmers, Dagmar-Christiane Fischer
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Hanne Honerlagen, Henry Reyer, Ibrahim Abou-Soliman, Dierck Segelke, Siriluck Ponsuksili, Nares Trakooljul, Norbert Reinsch, Bjoern Kuhla, Klaus Wimmers
Summary: Improving the nitrogen-utilization efficiency (NUE) of dairy cows through breeding selection has benefits in terms of nutrition, environment, and economics. The individual milk urea concentration (MU) of cows has been proposed as an indicator trait for NUE. This study aimed to identify different microbial genera in the rumen of Holstein cows with divergent genomic breeding values for MU (GBVMU). The identified microbial genera were further investigated for their correlations with MU and other NUE-associated traits, providing insight into genetically determined N-utilization in Holstein cows.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Cell Biology
Julia Brenmoehl, Elli Brosig, Nares Trakooljul, Christina Walz, Daniela Ohde, Antonia Noce, Michael Walz, Martina Langhammer, Stefan Petkov, Monika Roentgen, Steffen Maak, Christina E. E. Galuska, Beate Fuchs, Bjoern Kuhla, Siriluck Ponsuksili, Klaus Wimmers, Andreas Hoeflich
Summary: This study investigated the contribution of non-mitochondrial and mitochondrial metabolic pathways in contracting muscles during repeated training. The results showed that marathon mice displayed increased glucose and fatty acid oxidation, reduced lactate dehydrogenase activity, and inhibited lactate formation compared to trained control mice. This suggests that marathon mice have enhanced metabolic flexibility towards lipid catabolism regulated by lactate dehydrogenase.
Review
Agriculture, Dairy & Animal Science
Benjamin Diehl, Michael Oster, Andreas Vernunft, Klaus Wimmers, Hartwig Bostedt
Summary: The losses of piglets in commercial pig farming remain a concern and sustainable breeding and management strategies are needed. This review systematically presents the three phases of neonatal adaptation in piglets and highlights the key developments and influencing factors in each phase.
ARCHIVES ANIMAL BREEDING
(2022)
Review
Biochemistry & Molecular Biology
Fabio Sarais, Alvaro Perdomo-Sabogal, Klaus Wimmers, Siriluck Ponsuksili
Summary: This review focuses on the latest discoveries of tsRNAs, with special attention to molecules initially thought to be associated with tiRNAs. The paper outlines their biological functions, provides a collection of useful databases, and discusses future research perspectives and applications in livestock basic and applied research.
