Article
Biochemistry & Molecular Biology
Hulya Bayir, John J. Maguire, Enrique Cadenas
Summary: Professor Valerian Kagan has made significant contributions in the field of redox biology, particularly in redox lipidomics and the identification of signaling pathways mediated by oxidatively modified phospholipids, which play essential roles in coordinating metabolism and physiology.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Cell Biology
Alaumy Joshi, Travis H. Richard, Vishal M. Gohil
Summary: Studies on mitochondrial phospholipids have revealed their crucial role in mitochondrial bioenergetics and human health. The composition and function of these phospholipids have been highly conserved, and recent advances in understanding their transport mechanisms have further enhanced our understanding of mitochondrial phospholipid homeostasis. Additionally, disruptions in mitochondrial phospholipid biosynthesis have been linked to various genetic diseases, and promising therapeutic strategies are being developed for these disorders.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Valeria Manganelli, Antonella Capozzi, Serena Recalchi, Gloria Riitano, Vincenzo Mattei, Agostina Longo, Roberta Misasi, Tina Garofalo, Maurizio Sorice
Summary: This study investigated the presence of cardiolipin (CL) within mitochondria-associated membranes (MAMs) following autophagic stimulus, and the potential role of CL-enriched raft-like microdomains as a signaling platform in autophagosome formation. The findings indicate that CL accumulates in MAM fractions after autophagic stimulation, where it interacts with proteins such as MFN2 and CANX, contributing to the multimolecular complex involved in autophagosome formation. This suggests that CL may have structural and functional implications in the pathophysiology of neurodegenerative diseases.
Article
Endocrinology & Metabolism
Gregor Oemer, Jakob Koch, Yvonne Wohlfarter, Katharina Lackner, Rita E. M. Gebert, Stephan Geley, Johannes Zschocke, Markus A. Keller
Summary: Tafazzin deficiency in Barth syndrome leads to severe symptoms including cardiomyopathy, neutropenia, myopathy, and short stature, with significant changes in cardiolipin composition. The composition of cardiolipins strongly depends on the surrounding lipid environment, and variations in nutritional lipid pools can affect phospholipid profiles. Future research will focus on the metabolic implications of different lipid states and tafazzin function on cardiolipin and phospholipid homeostasis.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Pushpa Raj Joshi, Maria Graefin zu Stolberg-Stolberg, Leila Motlagh Scholle, Beate Meinhardt, Elena Pegoraro, Stephan Zierz
Summary: This study found that the thermolability of the CPT II variant in muscle homogenate is similar to that of the wild-type, contrary to previous findings. Additionally, it was observed that CLP stimulates the CPT II enzyme in muscle homogenate, aligning with the effects on recombinant enzymes.
Article
Biochemistry & Molecular Biology
Lauren M. Doolittle, Katherine Binzel, Katherine E. Nolan, Kelsey Craig, Lucia E. Rosas, Matthew C. Bernier, Lisa M. Joseph, Parker S. Woods, Michael Knopp, Ian C. Davis
Summary: This study found that inhibition of phosphatidylcholine synthesis affects the mitochondrial function of alveolar type II (ATII) epithelial cells in mice infected with influenza virus. Administration of the phosphatidylcholine precursor cytidine 5'-diphosphocholine (CDP-choline) improves this mitochondrial dysfunction.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Akira Murakami, Kohjiro Nagao, Reiko Sakaguchi, Keisuke Kida, Yuji Hara, Yasuo Mori, Kohki Okabe, Yoshie Harada, Masato Umeda
Summary: Intracellular temperature in animal cells remains unclear if it is autonomously controlled as a response to environmental temperature fluctuations. This study shows that the intracellular temperature in Drosophila S2 cells is maintained by the enzyme DESAT1, which enhances mitochondrial respiration and thermogenesis. Cold exposure also stimulates DESAT1-mediated mitochondrial remodeling, leading to increased temperature control.
Article
Biochemistry & Molecular Biology
Georgios Vasilopoulos, Roman Moser, Jonas Petersen, Meriyem Aktas, Franz Narberhaus
Summary: Bacterial membranes are primarily composed of phosphatidylethanolamine (PE), phosphatidylglycerol (PG) and cardiolipin (CL). Some bacteria also produce phosphatidylcholine (PC), the hallmark of eukaryotic membranes. The biosynthesis pathways for PC and CL in bacteria have been studied, revealing enzyme activities involved in these processes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
Kailash Venkatraman, Christopher T. Lee, Guadalupe C. Garcia, Arijit Mahapatra, Daniel Milshteyn, Guy Perkins, Keun-Young Kim, H. Amalia Pasolli, Sebastien Phan, Jennifer Lippincott-Schwartz, Mark H. Ellisman, Padmini Rangamani, Itay Budin
Summary: The architecture of the inner mitochondrial membrane is not only regulated by proteins, but also influenced by specific lipids. This study reveals the crucial role of cardiolipin in buffering the curvature loss and promoting cristae formation.
Review
Biochemistry & Molecular Biology
Rezlene Bargui, Audrey Solgadi, Bastien Prost, Melanie Chester, Ana Ferreiro, Jerome Piquereau, Maryline Moulin
Summary: Phospholipids are essential for cellular life, playing key roles in cell compartmentation and various cellular processes. Advances in phospholipid detection and identification methods are helping to understand their pivotal role in life processes. Imbalance in phospholipid homeostasis is linked to human diseases, particularly those with muscular phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Mukesh Mahajan, Nikhil Bharambe, Yutong Shang, Bin Lu, Abhishek Mandal, Pooja Madan Mohan, Rihua Wang, Jennifer C. Boatz, Juan Manuel Martinez Galvez, Anna Shnyrova, Xin Qi, Matthias Buck, Patrick C. A. van der Wel, Rajesh Ramachandran
Summary: The study elucidated the interaction mechanism between Drp1 and mitochondrial outer membrane cardiolipin, which triggers mitochondrial hyperfragmentation under stress conditions. Mutations in the CBM weakened this interaction, impairing Drp1-dependent fission under stress and inducing the formation of donut-shaped mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Sehwan Jang, Sabzali Javadov
Summary: Cardiolipin is a unique phospholipid that plays vital roles in resisting osmotic rupture and stabilizing large membrane proteins in the inner mitochondrial membrane. It forms covalently bonded net-like structures through oxidative polymerization, which is essential for maintaining the complex geometry of the mitochondria and gluing the quaternary structure of large protein complexes.
Article
Biochemistry & Molecular Biology
Gregor Oemer, Marie-Luise Edenhofer, Yvonne Wohlfarter, Katharina Lackner, Geraldine Leman, Jakob Koch, Luiza H. D. Cardoso, Herbert H. Lindner, Erich Gnaiger, Sandrine Dubrac, Johannes Zschocke, Markus A. Keller
Summary: Research shows that the functionality and structure of mitochondria are strongly influenced by the type of lipids in the growth medium, with lipid environment affecting the composition of mitochondrial cardiolipins and favoring the incorporation of essential linoleic acid. This raises further questions on the link between membrane composition and respiratory control.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Medicine, Research & Experimental
Arpita Chowdhury, Angela Boshnakovska, Abhishek Aich, Aditi Methi, Ana Maria Vergel Leon, Ivan Silbern, Christian Luechtenborg, Lukas Cyganek, Jan Prochazka, Radislav Sedlacek, Jiri Lindovsky, Dominic Wachs, Zuzana Nichtova, Dagmar Zudova, Gizela Koubkova, Andre Fischer, Henning Urlaub, Britta Bruegger, Doerthe M. Katschinski, Jan Dudek, Peter Rehling
Summary: Mitochondria play a central role in cellular metabolism and energy supply. Barth syndrome (BTHS) is a severe disorder caused by dysfunction of the mitochondrial cardiolipin acyl transferase tafazzin. A mouse model carrying a G197V mutation in tafazzin was found to recapitulate the pathological features of BTHS. Mutant mitochondria displayed impaired fatty acid-driven oxidative phosphorylation and a metabolic shift to glycolysis, leading to altered metabolic signaling and cardiac dysfunction. Treatment with an AMPK activator restored fatty acid-driven oxidative phosphorylation and protected against cardiac dysfunction in mice.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, Moshe Arditi
Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)